RESUMO
Background The Domus study, a randomized controlled trial (RCT), evaluated the effect of home-based specialized palliative care (SPC) reinforced with a psychological intervention for the patient-caregiver dyad on increasing advanced cancer patients' time spent at home, as opposed to hospitalized, and the number of home deaths. As palliative care extends to include support for patients' families and may thus assist caregivers and decrease demands on them, in this study we evaluated a secondary outcome, caregiver burden.Material and Methods Patients with incurable cancer and their caregivers were randomized (1:1) to care as usual or home-based SPC. Caregiver burden was assessed using the Zarit Burden Interview (ZBI) at baseline and 2, 4, 8 weeks and 6 months after randomization. Intervention effects were assessed in mixed effects models.Results A total of 258 caregivers were enrolled. Eleven per cent of informal caregivers experienced severe caregiver burden at baseline. Caregiver burden increased significantly over time in both groups (p = 0.0003), but no significant effect of the intervention was seen on overall caregiver burden (p = 0.5046) or burden subscales measuring role and personal strain.Conclusion In line with the majority of previous RCTs, the Domus intervention was not able to significantly reduce caregiver burden. Future interventions should consider targeting only caregivers reporting the greatest caregiver burden.
Assuntos
Neoplasias , Cuidados Paliativos , Humanos , Cuidados Paliativos/métodos , Sobrecarga do Cuidador , Intervenção Psicossocial , Cuidadores/psicologia , Neoplasias/terapia , Neoplasias/psicologia , Qualidade de VidaRESUMO
Comorbidity between smoking and chronic pain is well-documented, but gender differences in the pain-smoking relationship are not well understood. Although men experience greater acute analgesic benefit from smoking, pain may be more highly related to nicotine dependence and barriers to quitting among women. Utilizing a large, representative sample of adults in Denmark (N = 18,019), the current study examined gender as a moderator of the relationship between pain and smoking. Being a current smoker was related to greater likelihood of experiencing pain in univariate analysis (Chi-Square = 67.07, p < .01). In the multivariate logistic regression analysis, being male (log odds = .28, p < .01), having pain (log odds = .37, p < .01), and having lower education level (log odds = -.37, p < .01) increased the likelihood of being a current smoker. The negative Gender X Pain interaction was also significant (log odds = -.17, p = .02), indicating that among males, the effect (in log odds) of Pain on Smoking was lower, when compared to females. The stronger relationship between pain and smoking observed among women may indicate that women are more likely to use smoking means of coping with pain than men. It is also possible that over the long-term, smoking exacerbates painful conditions to a higher degree among women than men. Future research should seek to clarify differences in smoking negative reinforcement expectancies, nicotine dependence, and barriers to quitting between male and female smokers with pain.