The Smelling Principle of Vetiver Oil, Unveiled by Chemical Synthesis.

Vetiver oil, produced on a multiton-scale from the roots of vetiver grass, is one of the finest and most popular perfumery materials, appearing in over a third of all fragrances. It is a complex mixture of hundreds of molecules and the specific odorant, responsible for its characteristic suave and sweet transparent, woody-ambery smell, has remained a mystery until today. Herein, we prove by an eleven-step chemical synthesis, employing a novel asymmetric organocatalytic Mukaiyama-Michael addition, that (+)-2-epi-ziza-6(13)en-3-one is the active smelling principle of vetiver oil. Its olfactory evaluation reveals a remarkable odor threshold of 29 picograms per liter air, responsible for the special sensuous aura it lends to perfumes and the quasi-pheromone-like effect it has on perfumers and consumers alike.

Pyrolysis of Iron-Containing Polyanilines under Micropore Generation Control: Electrocatalytic Performance in the Oxygen Reduction Reaction.

Pyrolyzed iron-containing polyaniline (C-Fe-PANI) is one of the most promising candidates as a non-precious metal based electrocatalyst for oxygen reduction reaction (ORR). Although the ORR activity depends on the surface area arisen from pyrolysis-generated micropores on C-Fe-PANI particles, the micropore generation is hindered by pyrolysis-formed iron nanoparticles (Fe NPs) embedded inside C-Fe-PANI particles. Here, we demonstrate the pyrolysis of iron-containing PANIs under suppression of micropore-generation hindrance by blocking the Fe NPs formation. The higher-molecular-weight (MW: 100,000) PANI was dispersed in an FeCl3 solution before pyrolysis for preventing FeCl3 penetration inside PANI particles. As a result, as compared to the case of lower-MW (5,000) PANI, the Fe NPs formation was more suppressed inside catalyst particles to give 1.9 (1.8) times micropore volume (specific surface area), leading to a 11 % higher current density in ORR electrocatalytic performance test in acidic media.

Depression and Anxiety as Key Factors Associated With Quality of Life Among Lung Cancer Patients in Hai Phong, Vietnam.

Background: Cancer is a leading cause of death. People living with cancer experience a variety of symptoms that might profoundly affect their quality of life (QoL). Objective: The study aims to identify factors associated with the QoL of patients with lung cancer at the oncology department of Viet Tiep Hospital, Hai Phong city, Vietnam in 2018. Methods: A cross-sectional study was conducted to collect data from lung cancer inpatients in Hai Phong city, Vietnam. The EQ-5D-5L and the EuroQol (EQ)-visual analogue scale (EQ VAS) were used to assess health-related quality of life (QoL). A multivariable regression analysis was performed on the EQ-5D utility score and the EQ VAS score as dependent variables, and socioeconomic, social support, and psychological factors as potential predictors. Results: A total of 125 lung cancer patients were enrolled in this study. The highest proportion of respondents reporting any problems was in anxiety/depression (92.8%), pain/discomfort (81.2%), usual activities (75.2%), and mobility (60%) dimensions, while the lowest percentage was in self-care dimension (40.8%). The multivariate analyses showed that a low QoL score was significantly associated with depression, incapacity to pay, low response to treatment, and presence of side effects. Conclusion: QoL of lung cancer patients is associated with anxiety/depression and other factors that can be modified by specific interventions. It is therefore possible to take care of psychological aspects to improve the QoL of Vietnamese people suffering from this condition.

Tibial tunnel defect size as a risk factor in growth arrest following paediatric transphyseal anterior cruciate ligament reconstruction: an anatomical study.

BACKGROUND: There is ongoing controversy regarding growth disturbances in younger patients undergoing anterior cruciate ligament reconstructions. Animal models have shown that an injury of 7-9% of the physeal area is a risk factor for growth disturbances. METHODS: A total of 39 magnetic resonance imaging studies of the knee were examined. The proximal tibial physeal area was determined using a calibrated 'region of interest' ligature encompassing the tibial physis in the axial plane. The potential defect left by commonly used drill sizes was calculated as a percentage of the physeal area. RESULTS: A 7-mm drill leaves a mean defect of 1.45% physeal area (range: 1.11-1.89%, SD: 0.28, 95% CI: ±0.09), 8-mm drill leaves a 1.84% mean defect (range: 1.43-2.49%, SD: 0.38, 95% CI: ±0.12) and a 9-mm drill leaves a 2.30% mean defect (range: 1.83-3.19%, SD: 0.58, 95% CI: ±0.17). At 55°, 7-mm drill leaves a mean defect of 1.96% (range: 1.32-2.28%, SD: 0.37, 95% CI: ±0.12), 8-mm drill leaves a mean defect of 2.19% (range: 1.71-2.95%, SD: 0.46, 95% CI: ±0.14) and a 9-mm drill leaves a mean defect of 2.76% (range: 2.16-3.73%, SD: 0.58, 95% CI: ±0.18). There was a statistically significant difference in the tunnel area with a change of drill angle (7-mm drill P = 0.005, 8-mm drill P = 0.001, 9-mm drill P = 0.001). CONCLUSION: On the basis of this study in the context of animal model and observational evidence, the area of physeal injury using drill tunnels for anterior cruciate ligament reconstruction would not appear to contribute to potential growth disturbances.

Cutaneous burns from a fiberoptic cable tip during arthroscopy of the knee.

Thermal skin injury is a rare complication of arthroscopy. The potential of fiberoptic light cable tips to cause cutaneous burns has been previously investigated, but no cases have been reported. We present a case report of such an injury. In order to improve patient safety, we further recommend always checking that the light source is set on standby prior to disconnecting the light cable from the arthroscope and that the light cable tip is never left on the patient when not in use.