RESUMO
Objectives: Carpal tunnel syndrome (CTS) is a disorder caused by median nerve pressure inside the carpal tunnel in the wrist area. Recent evidences have demonstrated a role of cytokines in CTS. It is still controversial whether idiopathic CTS is an inflammatory or non-inflammatory disorder. Accordingly, the purpose of the current research was to assess serum levels of inflammatory cytokines in patients with idiopathic carpal tunnel syndrome in comparison with healthy participants.Methods: This case-control research was performed on 40 female patients with idiopathic carpal tunnel syndrome and 40 healthy controls. After identifying the participants, the serum levels of four cytokines (TNF-α, IL-2, IL-4, IL-6, and IL-10) were calculated by ELIZA method. SPSS statistical analysis was performed after entering data. p-values ≤ 0.05 was deliberated statistically significant.Results: The mean age was 45.07 ± 8.52 years in the patient group and 45.32 ± 8.42 years in the control group. The concentration of TNFα, IL1, IL6 and IL10 was 3.84 ± 0.44, 3.20 ± 0.71, 3.37 ± 1.26 and 6.21 ± 3.38 in patient group. The current study results demonstrated that there was no statistically significant difference among the case and control groups.Conclusions: This study showed that, serum levels of inflammatory cytokines (IL1, IL6, IL10 and TNFα) had no meaningful changes in patients with carpal tunnel syndrome and the role of these inflammatory mediators in this disease is still unclear.