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1.
Int J Radiat Oncol Biol Phys ; 118(3): 759-769, 2024 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-37820770

RESUMO

PURPOSE: Survivors of head and neck cancer may have significant lasting impairments and poor access to rehabilitation. To address this, our group developed and evaluated a rehabilitation planning consult (RPC). The RPC is conducted through an initial consultation and a single follow-up session with a rehabilitation professional. During the initial consultation, rehabilitation needs are determined and the survivor sets individualized goals and plans. They then implement their plans independently and are facilitated to evaluate and modify plans as necessary during the follow-up session. METHODS AND MATERIALS: We used a waitlist control design to compare the proportion of participants attaining a minimally importantly different change in quality of life (QOL) on the Short Form 36 Physical Health Summary Score from baseline to 3 months after study enrollment, between patients randomized to receive (n = 77) or wait 14 ± 3 weeks to receive (n = 76) the RPC. Additional outcomes included goal attainment indicators measured using the Brief Rehabilitation Assessment for Survivors of Head and Neck Cancer (BRASH). RESULTS: Of 153 participants recruited, 95 (62%) completed the intervention; 57 were in the immediate (RPC) group and 38 were in the waiting list control (WLC) group. No significant between-group differences were seen in the proportion of patients achieving a minimally important improvement (2.5 units) on the Physical Health Summary Score from baseline to 3 months after recruitment. No between-group differences were seen on any secondary QOL indicators. Among the 67 (RPC n = 42, WLC n = 22) participants who set individualized rehabilitation goals, BRASH scores on goal performance and satisfaction with goal performance were significantly better in the RPC group. CONCLUSIONS: Our results suggest that the RPC may provide benefit in patients' individualized domains of choice among those who set goals, without affecting overall QOL. Future work could refine the subset of patients who benefit and explore the optimal timing and intensity of the intervention.


Assuntos
Neoplasias de Cabeça e Pescoço , Qualidade de Vida , Humanos , Sobreviventes , Encaminhamento e Consulta
2.
MDM Policy Pract ; 7(2): 23814683221142267, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36532295

RESUMO

Introduction. Generic preference-based instruments inadequately measure breast cancer (BrC) health-related quality-of-life preferences given advances in therapy. Our overall purpose is to develop the Breast Utility Instrument (BUI), a BrC-specific preference-based instrument. This study describes the selection of the BUI items. Methods. A total of 408 patients from diverse BrC health states completed the EORTC QLQ-C30 and BR45 (breast module). For each of 10 dimensions previously assessed with confirmatory factor analysis, we evaluated data fit to the Rasch model based on global model and item fit, including threshold ordering, item residuals, infit and outfit, differential item functioning (age), and unidimensionality. Misfitting items were removed iteratively, and the model fit was reassessed. From items fitting the Rasch model, we selected 1 item per dimension based on high patient- and clinician-rated item importance, breadth of item thresholds, and clinical relevance. Results. Global model fit was good in 7 and borderline in 3 dimensions. Separation index was acceptable in 4 dimensions. Item selection criteria were maximized for the following items: 1) physical functioning (trouble taking a long walk), 2) emotional functioning (worry), 3) social functioning (interfering with social activities), 4) pain (having pain), 5) fatigue (tired), 6) body image (dissatisfied with your body), 7) systemic therapy side effects (hair loss), 8) sexual functioning (interest in sex), 9) breast symptoms (oversensitive breast), and 10) endocrine therapy symptoms (problems with your joints). Conclusions. We propose 10 items for the BUI. Our next steps include assessing the measurement properties prior to eliciting preference weights of the BUI. Highlights: A previous confirmatory factor analysis established 10 dimensions of the European Organisation for Research and Treatment of Cancer (EORTC) core quality of life questionnaire (QLQ-C30) and its breast module (BR45).In this study, we selected 1 item per dimension based on fit to the Rasch model, patient- and clinician-rated item importance, breadth of item thresholds, and clinical relevance.These items form the core of the future Breast Utility Instrument (BUI).The future BUI will be a novel breast cancer-specific preference-based instrument that potentially will better reflect women's preferences in clinical decision making and cost utility analyses.

3.
PLoS One ; 17(12): e0278368, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36454910

RESUMO

BACKGROUND: Initiation of anti-osteoporosis medications after hip fracture lowers the risk of subsequent fragility fractures. Historical biases of targeting secondary fracture prevention towards certain groups may result in treatment disparities. We examined associations of patient age, sex and race with anti-osteoporosis medication prescription following hip fracture. METHODS: A cohort of patients with a hip fracture between 2016-2018 was assembled from the American College of Surgeons National Surgical Quality Improvement Program registry. Patients on anti-osteoporosis medications prior to admission were excluded. Multivariable logistic regression was used to determine adjusted associations between patient age, sex and race and their interactions with prescription of anti-osteoporosis medications within 30 days of surgery. RESULTS: In total, 12,249 patients with a hip fracture were identified with a median age of 82 years (IQR: 73-87), and 67% were female (n = 8,218). Thirty days postoperatively, 26% (n = 3146) of patients had been prescribed anti-osteoporosis medication. A significant interaction between age and sex with medication prescription was observed (p = 0.04). Male patients in their 50s (OR:0.75, 95%CI:0.60-0.92), 60s (OR:0.81, 95%CI:0.70-0.94) and 70s (OR:0.89, 95%CI:0.81-0.97) were less likely to be prescribed anti-osteoporosis medication compared to female patients of the same age. Patients who belonged to minority racial groups were not less likely to receive anti-osteoporosis medications than patients of white race. INTERPRETATION: Only 26% of patients were prescribed anti-osteoporosis medications following hip fracture, despite consensus guidelines urging early initiation of secondary prevention treatments. Given that prescription varied by age and sex, strategies to prevent disparities in secondary fracture prevention are warranted.


Assuntos
Fraturas do Quadril , Osteoporose , Humanos , Feminino , Masculino , Idoso , Idoso de 80 Anos ou mais , Lactente , Estudos Retrospectivos , Fraturas do Quadril/prevenção & controle , Fraturas do Quadril/cirurgia , Osteoporose/complicações , Osteoporose/tratamento farmacológico , Sistema de Registros , Prescrições de Medicamentos
4.
PLoS One ; 17(2): e0262635, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35120148

RESUMO

OBJECTIVES: Breast cancer (BrC) and its treatments impair health-related quality of life (HRQoL). Utility is a measure of HRQoL that includes preferences for health outcomes, used in treatment decision-making. Generic preference-based instruments lack BrC-specific concerns, indicating the need for a BrC-specific preference-based instrument. Our objective was to determine dimensions of the European Organisation for Research and Treatment of Cancer (EORTC) general cancer (QLQ-C30) and breast module (BR45) instruments, the first step in our development of the novel Breast Utility Instrument (BUI). METHODS: Patients (n = 408) attending outpatient BrC clinics at an urban cancer centre, and representing a spectrum of BrC health states, completed the QLQ-C30 and BR45. We performed confirmatory factor analysis of the combined QLQ-C30 and BR45 using mean-and variance-adjusted unweighted least squares estimation. The hypothesized factor model was based on clinical relevance, item distributions, missing data, item-importance, and internal reliability of dimensions. Models were evaluated based on global and item fit, local areas of strain, and likelihood ratio tests of nested models. RESULTS: Our final model had 10 dimensions: physical and role functioning, emotional functioning, social functioning, body image, pain, fatigue, systemic therapy side effects, sexual functioning and enjoyment, arm and breast symptoms, and endocrine therapy symptoms. Good overall model fit was achieved: χ2/df: 1.45, Tucker-Lewis index: 0.946, comparative fit index: 0.951, standardized root-mean-square residual: 0.069, root-mean-square error of approximation: 0.033 (0.030-0.037). All items had salient factor loadings (λ>0.4, p<0.001). CONCLUSIONS: We identified important BrC HRQoL dimensions to develop the BUI, a BrC-specific preference-based instrument.


Assuntos
Neoplasias da Mama
5.
J Orthop Trauma ; 36(6): e236-e242, 2022 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-34744152

RESUMO

OBJECTIVE: To (1) identify predictors of subsequent surgery after initial treatment of proximal humerus fractures (PHFs) and (2) generate valid risk prediction tools to predict subsequent surgery. METHODS: We identified patients ≥50 years with PHF from 2004 to 2015 using health data sets in Ontario, Canada. We used procedural codes to classify patients into treatment groups of (1) surgical fixation, (2) shoulder replacement, and (3) conservative. We used procedural and diagnosis codes to capture subsequent surgery within 2 years after fracture. We developed regression models for two-thirds of each group to identify predictors of subsequent surgery and the regression equations to develop risk tools to predict subsequent surgery. We used the final third of each cohort to evaluate the discriminative ability of the risk tools using c-statistics. RESULTS: We identified 20,897 patients with PHF, 2414 treated with fixation, 1065 with replacement, and 17,418 treated conservatively. Predictors of reoperation after fixation included bone grafting and nail or wire fixation versus plate fixation, whereas poor bone quality was associated with reoperation after initial replacement. In conservatively treated patients, more comorbidities were associated with subsequent surgery, whereas age 70+ and discharge home after presentation lowered the odds of subsequent surgery. The risk tools were able to discriminate with c-statistics of 0.75-0.88 (derivation) and 0.51-0.79 (validation). CONCLUSIONS: Our risk tools showed good to strong discriminative ability for patients treated conservatively and with fixation. These data may be used as the foundation to develop a clinically informative tool. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.


Assuntos
Fraturas do Ombro , Ombro , Idoso , Placas Ósseas , Fixação Interna de Fraturas/efeitos adversos , Humanos , Úmero/cirurgia , Ontário/epidemiologia , Complicações Pós-Operatórias/cirurgia , Fraturas do Ombro/cirurgia , Resultado do Tratamento
6.
J Surg Oncol ; 121(4): 630-637, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31957034

RESUMO

BACKGROUND AND OBJECTIVES: Limb salvage surgery remains the standard treatment in bone and soft tissue tumors. Toronto Extremity Salvage Score (TESS) is the most used quality of life measure. Our objective was to perform cross-cultural adaptation and validation in Italian, testing test-retest reliability, construct validity, and responsiveness. METHODS: We interviewed patients already treated for content validity. A total of 124 patients completed TESS and other questionnaires presurgery, at 3 months, 3 months + 2 weeks, and 6 months follow-up. We calculated intraclass correlation coefficients (ICCs) for reliability, associations with Pearson's r, and change over time with paired T tests. RESULTS: A new item regarding touch-screen devices was added to the upper extremity (UE) questionnaire. ICC resulted of 0.99 for lower extremity (LE) and 0.98 for UE patients, Pearson's r between TESS and Musculoskeletal Tumor Society was .66 and .64, EuroQol-5D-5L r was .62 and .61, and r between TESS and short form-36 physical function subscale was .76 and .71 for LE and UE groups, respectively. Paired T test results were statistically significant to detect change over time (0.03, 0.04, and 0.04 for LE groups and 0.03, 0.01, and 0.04 for UE groups). CONCLUSION: The Italian version of TESS can be used for the bone and soft tissue sarcoma population in clinical trials in Italy and with Italian speaking patients abroad to ensure patients' perspectives for efficacy and efficiency of treatments.


Assuntos
Neoplasias Ósseas/psicologia , Neoplasias Ósseas/cirurgia , Salvamento de Membro/psicologia , Osteossarcoma/psicologia , Osteossarcoma/cirurgia , Sarcoma/psicologia , Sarcoma/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias Ósseas/patologia , Comparação Transcultural , Extremidades/patologia , Extremidades/cirurgia , Feminino , Humanos , Itália , Idioma , Salvamento de Membro/métodos , Masculino , Pessoa de Meia-Idade , Osteossarcoma/patologia , Qualidade de Vida , Reprodutibilidade dos Testes , Sarcoma/patologia , Índice de Gravidade de Doença , Inquéritos e Questionários , Tradução , Adulto Jovem
7.
Disabil Rehabil ; 41(17): 2093-2107, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-29976091

RESUMO

Purpose: The objectives of this scoping review were to summarize, understand, and disseminate findings from a broad body of literature on rehabilitation interventions used with survivors of head and neck cancer. Method: Searches were conducted in six databases. Inclusion criteria were studies of adult head and neck cancer survivors with a predefined primary rehabilitation outcome as a result of an intervention. Excluded were studies not written in English, opinion papers, or studies where the intervention was not carried out by a rehabilitation healthcare service. A second level, full-text review of the studies was conducted. A thematic analysis was used to examine and combine study findings. Results: A total of 3804 results were retrieved from all sources resulting in 39 papers that were analyzed. The thematic analysis of the included papers represented interventions focusing on swallowing and nutrition, speech, physical therapy, assistive devices, complementary and alternative modalities, comprehensive interdisciplinary programs, and preventive rehabilitation programs. Conclusion: This review has provided an overview of the scope of rehabilitation interventions available for survivors of head and neck cancer and preliminary information about their efficacy. This is foundational information for the development and refinement of rehabilitation interventions and programs for head and neck cancer survivors. Implications for Rehabilitation The existing evidence suggests that survivors of head and neck cancer can benefit from early screening of potential rehabilitation needs and being involved in preventive rehabilitation programs pre-surgery when possible. Rehabilitation programs should consider swallowing interventions for patients as evidence reports improved swallowing function, decreased pain and discomfort, and reduced duration of feeding tube use. Rehabilitation programs should consider nutritional interventions after radiotherapy: Patients benefited from stabilized weights, improved nutritional status, and an improved quality of life. Physical exercise interventions demonstrated improvements in physical function, muscular endurance, range of motion, overall quality of life, and showed reductions in pain, and fatigue.


Assuntos
Sobreviventes de Câncer , Transtornos de Deglutição/reabilitação , Neoplasias de Cabeça e Pescoço/reabilitação , Distúrbios da Fala/reabilitação , Terapias Complementares , Transtornos de Deglutição/etiologia , Transtornos de Deglutição/prevenção & controle , Neoplasias de Cabeça e Pescoço/complicações , Humanos , Desnutrição/prevenção & controle , Equipe de Assistência ao Paciente , Modalidades de Fisioterapia , Qualidade de Vida , Tecnologia Assistiva , Distúrbios da Fala/etiologia
8.
CMAJ Open ; 6(3): E269-E275, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30026190

RESUMO

BACKGROUND: It has been suggested that total knee replacement is being performed in people with less-severe osteoarthritis. We aimed to determine whether there were differences in the presurgery profile, symptoms and disability of 2 cohorts who underwent total knee replacement over a 10-year period. METHODS: Patients aged 18-85 years undergoing primary total knee replacement for osteoarthritis at 1 of 4 sites in Toronto and Strathroy, Ontario, were recruited in a cohort study during 2006-2008 (cohort 1) and 2012-2015 (cohort 2). Patients undergoing unicompartmental or revision arthroplasty were excluded. Demographic and health (body mass index [BMI], comorbidity) variables and osteoarthritis severity, as assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the disability component of the Late-Life Function and Disability Instrument (LLFDI-D), were collected before surgery. We calculated proportions, means and standard deviations with 95% confidence intervals (CIs) for all data. We constructed density plots by tertile score for the WOMAC pain and physical function subscales and the LLFDI-D limitation scale. RESULTS: There were 494 patients in cohort 1 and 251 patients in cohort 2. There were no differences in age, sex, education, living status, BMI, comorbidity, pain severity or disability between the cohorts based on overlapping 95% CIs and the density plots. More patients in cohort 1 than in cohort 2 were single (176 [35.6%], 95% CI 32.5%-41.1% v. 63 [25.1%], 95% CI 20.3%-31.0%). Patients in cohort 2 reported less limitation in higher-demand activities than did those in cohort 1 (mean score on LLFDI-D 62.3 [95% CI 60.7-63.9] v. 59.2 [95% CI 58.2-60.2]). INTERPRETATION: The patient profile and reported osteoarthritis severity were similar in 2 cohorts that had total knee replacement over a 10-year period. This suggests that increasing total knee replacement volumes over this period likely were not driven by these factors.

9.
Head Neck ; 40(7): 1415-1424, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29566448

RESUMO

BACKGROUND: The rehabilitation planning consult (RPC) is a novel, transdisciplinary rehabilitation intervention for survivors of head and neck cancer. The study aimed to: (1) estimate recruitment and withdrawal rates, and adverse events; and (2) estimate the effect on rehabilitation indicators in survivors of head and neck cancer. METHODS: A single group pre-post study with follow-up was conducted with survivors of head and neck cancer who had completed treatment within 18 months. Outcome measures included goal attainment and quality of life indicators. RESULTS: Thirty participants (30) completed the RPC, and 20 completed follow-up. The average age was 59.8 years (SD 13.3), 23 were men, and 23 set rehabilitation goals. At follow-up, there was a large effect on goal performance (d = 1.5) and satisfaction (d = 1.5), and on the Short Form Health Survey-36 (SF-36) physical role and social functioning subscales (d = 1.0 and 0.8). There was a small to moderate effect on most other outcomes. CONCLUSION: The RPC is a promising transdisciplinary rehabilitation intervention warranting further study with a controlled trial.


Assuntos
Sobreviventes de Câncer , Neoplasias de Cabeça e Pescoço/reabilitação , Encaminhamento e Consulta , Feminino , Seguimentos , Objetivos , Humanos , Masculino , Pessoa de Meia-Idade , Ontário , Modalidades de Fisioterapia , Qualidade de Vida , Estudos de Amostragem , Autocuidado , Autoeficácia , Participação Social
10.
Neurology ; 89(23): 2357-2364, 2017 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-29101274

RESUMO

OBJECTIVE: To study responsiveness and meaningful change of the Myasthenia Gravis Impairment Index (MGII) and its relative efficiency compared to other measures. METHODS: We enrolled 95 patients receiving prednisone, IV immunoglobulin (IVIg), or plasma exchange (PLEX) and 54 controls. Patients were assessed with the MGII and other measures-including the Quantitative Myasthenia Gravis Score, Myasthenia Gravis Composite, and Myasthenia Gravis Activities of Daily Living-at baseline and 3-4 weeks after treatment. Statistical markers of responsiveness included between-groups and within-group differences, and we estimated the relative efficiency of the MGII compared to other measures. Patient-meaningful change was assessed with an anchor-based method, using the patient's impression of change. We determined the minimal detectable change (MDC) and the minimal important difference (MID) at the group and individual level. RESULTS: Treated patients had a higher change in MGII scores than controls (analysis of covariance p < 0.001). The ocular domain changed more with prednisone than with IVIg/PLEX (effect size 0.67 and 0.13, analysis of covariance p = 0.001). The generalized domain changed more with IVIg/PLEX than with prednisone (effect size 0.50 and 0.22, analysis of covariance p = 0.07). For the total MGII score, the individual MDC95 was 9.1 and the MID was 5.5 for individuals and 8.1 for groups. Relative efficiency ratios were >1 favoring the MGII. CONCLUSIONS: The MGII demonstrated responsiveness to prednisone, IVIg, and PLEX in patients with myasthenia. There is a differential response in ocular and generalized symptoms to type of therapy. The MGII has higher relative efficiency than comparison measures and is viable for use in clinical trials.


Assuntos
Miastenia Gravis/fisiopatologia , Atividades Cotidianas , Idoso , Anti-Inflamatórios/uso terapêutico , Avaliação da Deficiência , Olho/patologia , Feminino , Humanos , Imunização Passiva , Masculino , Pessoa de Meia-Idade , Miastenia Gravis/tratamento farmacológico , Miastenia Gravis/psicologia , Troca Plasmática , Prednisona/uso terapêutico , Reprodutibilidade dos Testes , Resultado do Tratamento
11.
BMJ Open ; 7(8): e015737, 2017 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-28821515

RESUMO

OBJECTIVE: The impact of the context of a person's life on recovery from surgical interventions is not well understood. This study evaluated if people's social, environmental and biomedical context was associated with change in frequency in engagement in life activities after total knee replacement (TKR). METHODS: 418 people aged 30+ years who had TKR were followed presurgery to 1 year postsurgery. The outcome was change in frequency in engagement in life activities measured by the Late Life Disability Index (LLDI). Predictor variables of interest evaluated in multivariable linear regression analysis were positive and negative life events (Life Experiences Survey), development of a new comorbidity, another joint replacement and complications after TKR surgery. RESULTS: Mean age was 65 years, 36% were male; 22% and 21% had no comorbidity presurgery and postsurgery. Presurgery LLDI frequency was 69.6 (±11.4) and the mean change was 6.1 (±10.2). Thirty-four per cent and 65% reported at least one positive or negative life event. Seven per cent developed hypertension, 6% cardiovascular disease, 2% lung disease and 2% diabetes. Eleven per cent had a complication and 9% another hip or knee replaced. Smaller changes in LLDI frequency were associated with more negative life events (beta=-0.56; 95% CI -0.92 to-0.18) and complications (beta=-4.01; 95% CI -6.63 to -1.38) after adjusting for age, sex, education, body mass index, comorbidities presurgery, number of symptomatic joints and knee-specific pain and function, LLDI limitations and depression. A new comorbidity or another joint replacement was not associated with outcome in unadjusted or adjusted analysis. CONCLUSIONS: Multifaceted life experiences shape the context of peoples' lives impacting their engagement in activities important for healthy living post-TKR.


Assuntos
Atividades Cotidianas , Artroplastia do Joelho , Articulação do Joelho/cirurgia , Acontecimentos que Mudam a Vida , Idoso , Artroplastia de Quadril , Canadá , Comorbidade , Depressão/etiologia , Avaliação da Deficiência , Feminino , Humanos , Articulação do Joelho/patologia , Masculino , Pessoa de Meia-Idade , Osteoartrite do Joelho/cirurgia , Dor/etiologia , Estudos Prospectivos , Análise de Regressão , Inquéritos e Questionários
12.
J Orthop Sci ; 22(1): 127-132, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27743633

RESUMO

BACKGROUND: The Toronto Extremity Salvage Score (TESS) is a widely used disease-specific patient-completed questionnaire for the assessment of physical function in patients with musculoskeletal tumors; however, there had not been the validated Japanese version of the TESS. The aim of this study was to validate the Japanese version of the TESS in patients with musculoskeletal tumors in the upper extremity. METHODS: After developing a Japanese version of the TESS, the questionnaire was administered to 53 patients to examine its reliability and validity in comparison with the Musculoskeletal Tumor Society (MSTS) scoring system and Short Form-36 (SF-36). RESULTS: Test-retest reliability with intraclass correlation coefficient (0.93) and internal consistency with Cronbach's alpha (0.90) were excellent. Factor analysis showed that the construct structure consisted of 3-item clusters, and the Akaike Information Criterion network also demonstrated that the items could be divided into 3 domains according to their content. The TESS strongly correlated with the MSTS rating scale (r = 0.750; P < 0.001) and the SF-36 physical functioning scale (r = 0.684; P < 0.001). However, as expected, the TESS had low correlations with the SF-36 mental health and role-emotional subscales and the MSTS scoring system manual dexterity domain. CONCLUSIONS: Our study suggests that the TESS is a reliable and valid instrument to measure patient-reported physical functioning in patients with upper extremity sarcoma.


Assuntos
Neoplasias Ósseas/cirurgia , Comparação Transcultural , Salvamento de Membro/métodos , Neoplasias de Tecidos Moles/cirurgia , Inquéritos e Questionários , Adaptação Psicológica , Adolescente , Adulto , Idoso , Neoplasias Ósseas/etnologia , Neoplasias Ósseas/patologia , Estudos Transversais , Feminino , Humanos , Japão , Salvamento de Membro/psicologia , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica/patologia , Estadiamento de Neoplasias , Ontário , Medição de Risco , Neoplasias de Tecidos Moles/etnologia , Neoplasias de Tecidos Moles/patologia , Resultado do Tratamento , Extremidade Superior , Adulto Jovem
13.
J Surg Oncol ; 114(7): 821-827, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27634326

RESUMO

BACKGROUND AND OBJECTIVES: The primary objective of this study was to estimate the change in health-related quality of life (HRQL) 1 year following treatment for extremity soft tissue sarcoma (STS), measured by the EQ-5D. Secondary objectives included determining clinical variables associated with HRQL at 1 year, estimating the proportion with a clinically important difference (CID) in HRQL, and evaluating variability within EQ-5D domains. METHODS: Patients over the age of 16 years, treated for a localized extremity STS, were included. The EQ-5D change score from pre-treatment to 1-year follow-up was determined. The association of clinical variables with EQ-5D scores was estimated using a linear regression model. The proportion of patients with a CID in HRQL score was determined. A vector analysis of the EQ-5D domains was undertaken. RESULTS: The mean EQ-5D change score was 0.02. Age, sex, disease status, and initial EQ-5D score were associated with EQ-5D score at 1 year. There was a CID improvement in 32% and a deterioration in 24%. The anxiety and depression domain demonstrated the most change between baseline and 1 year after treatment. CONCLUSION: Most patients maintain a high level of HRQL following treatment for extremity STS. J. Surg. Oncol. 2016;114:821-827. © 2016 2016 Wiley Periodicals, Inc.


Assuntos
Extremidades/cirurgia , Qualidade de Vida , Sarcoma/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Indicadores Básicos de Saúde , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados da Assistência ao Paciente , Qualidade de Vida/psicologia , Estudos Retrospectivos , Sarcoma/diagnóstico , Sarcoma/psicologia , Adulto Jovem
14.
World Neurosurg ; 93: 436-448.e15, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27424474

RESUMO

OBJECTIVE: Accurate prediction of surgical outcomes in patients suffering from metastatic epidural spinal cord compression (MESCC) is challenging. This survey aims to obtain expert opinion on which preoperative clinical factors are the most relevant predictors of survival, neurologic, functional, and health-related quality of life (HRQoL). METHODS: Members of AOSpine International were invited to participate in a 15-question electronic survey. Results from the entire sample and differences across geographic regions and between neurosurgeons and orthopedic surgeons were analyzed. Factors endorsed by over 50% of the respondents were considered key predictors. RESULTS: Among AOSpine members, 438 responded. The absence of visceral metastasis (n = 335; 76.48%) and the site of primary tumor (n = 228; 52.05%) were identified as important predictors for survival. Frankel/American Spinal Injury Association grade D or E and the ability to walk were common to neurologic (n = 344; 78.54% and n = 238; 54.34%, respectively); functional (n = 269; 61.42% and n = 243; 55.48%, respectively); and HRQoL outcomes (n = 241; 55.02% and n = 242; 55.25%, respectively). While the absence of bowel/bladder/sexual dysfunction was common to neurologic (n = 260; 59.36%) and HRQoL (n = 229; 52.28%) outcomes, a high Karnofsky/Eastern Cooperative Oncology Group performance status was common to functional (n = 237; 54.11%) and HRQoL (n = 221; 50.46%) outcomes. There was overall consistency across specialities and geographic regions. CONCLUSIONS: Neurosurgeons and orthopedic surgeons and respondents from different geographic regions generally identified similar preoperative clinical factors as key predictors of survival, neurologic, functional, and HRQoL outcomes in surgical MESCC patients. The results of this survey will inform the development of clinical prediction rules for survival and HRQoL in MESCC patients selected for surgery to maximize their clinical relevance.


Assuntos
Neurocirurgiões/estatística & dados numéricos , Cirurgiões Ortopédicos/estatística & dados numéricos , Avaliação de Resultados em Cuidados de Saúde , Compressão da Medula Espinal/mortalidade , Compressão da Medula Espinal/cirurgia , Neoplasias da Medula Espinal/secundário , Neoplasias da Medula Espinal/cirurgia , Atitude do Pessoal de Saúde , Comorbidade , Pesquisas sobre Atenção à Saúde , Incidência , Internacionalidade , Cuidados Pré-Operatórios/métodos , Prognóstico , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Compressão da Medula Espinal/diagnóstico , Neoplasias da Medula Espinal/mortalidade , Análise de Sobrevida , Avaliação de Sintomas
15.
Neurology ; 87(9): 879-86, 2016 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-27402891

RESUMO

OBJECTIVE: We aimed to develop a measure of myasthenia gravis impairment using a previously developed framework and to evaluate reliability and validity, specifically face, content, and construct validity. METHODS: The first draft of the Myasthenia Gravis Impairment Index (MGII) included examination items from available measures enriched with newly developed, patient-reported items, modified after patient input. International neuromuscular specialists evaluated face and content validity via an e-mail survey. Test-retest reliability was assessed in stable patients at a 3-week interval and interrater reliability was evaluated in the same day. Construct validity was assessed through correlations between the MGII and other measures and by comparing scores in different patient groups. RESULTS: The first draft was assessed by 18 patients, and 72 specialists answered the survey. The second draft had 7 examination and 22 patient-reported items. Field testing included 200 patients, with 54 patients completing the reliability studies. Test-retest reliability of the total score was good (intraclass correlation coefficient 0.92; 95% confidence interval 0.79-0.94), as was interrater reliability of the examination component (intraclass correlation coefficient 0.81; 95% confidence interval 0.79-0.94). The MGII correlated well with comparison measures, with higher correlations with the MG-activities of daily living (r = 0.91) and MG-specific quality of life 15-item scale (r = 0.78). When assessing different patient groups, the scores followed expected patterns. CONCLUSIONS: The MGII was developed using a patient-centered framework of myasthenia-related impairments and incorporating patient input throughout the development process. It is reliable in an outpatient setting and has demonstrated construct validity. Responsiveness studies are under way.


Assuntos
Miastenia Gravis/diagnóstico , Índice de Gravidade de Doença , Inquéritos e Questionários , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Miastenia Gravis/classificação , Miastenia Gravis/fisiopatologia , Miastenia Gravis/psicologia , Reprodutibilidade dos Testes
16.
J Bone Joint Surg Am ; 98(12): e50, 2016 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-27307368

RESUMO

BACKGROUND: U.S. practitioners have prescribed opioid analgesics increasingly in recent years, contributing to what has been declared an opioid epidemic by the U.S. Centers for Disease Control and Prevention (CDC). Opioids are used frequently in the preoperative and postoperative periods for patients undergoing total joint replacement in developed countries, but cross-cultural comparisons of this practice are limited. An international medical mission such as Operation Walk Boston, which provides total joint replacement to financially vulnerable patients in the Dominican Republic, offers a unique opportunity to compare postoperative pain management approaches in a developed nation and a developing nation. METHODS: We interviewed American and Dominican surgeons and nurses (n = 22) during Operation Walk Boston 2015. We used a moderator's guide with open-ended questions to inquire about postoperative pain management and factors influencing prescribing practices. Interviews were recorded and transcripts were analyzed using content analysis. RESULTS: Providers highlighted differences in the patient-provider relationship, pain medication prescribing variability, and access to medications. Dominican surgeons emphasized adherence to standardized pain protocols and employed a paternalistic model of care, and American surgeons reported prescribing variability and described shared decision-making with patients. Dominican providers described limited availability of potent opioid preparations in the Dominican Republic, in contrast to American providers, who discussed opioid accessibility in the United States. CONCLUSIONS: Our findings suggest that cross-cultural comparisons provide insight into how opioid prescribing practices, approaches to the patient-provider relationship, and medication access inform distinct pain management strategies in American and Dominican surgical settings. Integrating lessons from cross-cultural pain management studies may yield more effective pain management strategies for surgical procedures performed in the United States and abroad.


Assuntos
Analgésicos Opioides/uso terapêutico , Manejo da Dor/métodos , Dor Pós-Operatória/tratamento farmacológico , Relações Médico-Paciente , Padrões de Prática Médica , Tomada de Decisão Clínica , Comparação Transcultural , República Dominicana , Humanos , Estados Unidos
17.
BMC Musculoskelet Disord ; 17: 211, 2016 05 17.
Artigo em Inglês | MEDLINE | ID: mdl-27184397

RESUMO

BACKGROUND: Advanced osteoarthritis and total joint replacement (TJR) recovery are painful experiences and often prompt opioid use in developed countries. Physicians participating in the philanthropic medical mission Operation Walk Boston (OpWalk) to the Dominican Republic have observed that Dominican patients require substantially less opioid medication following TJR than US patients. We conducted a qualitative study to investigate approaches to pain management and expectations for postoperative recovery in patients with advanced arthritis undergoing TJR in the Dominican Republic. METHODS: We interviewed 20 patients before TJR about their pain coping mechanisms and expectations for postoperative pain management and recovery. Interviews were conducted in Spanish, translated, and analyzed in English using content analysis. RESULTS: Patients reported modest use of pain medications and limited knowledge of opioids, and many relied on non-pharmacologic therapies and family support to cope with pain. They held strong religious beliefs that offered them strength to cope with chronic arthritis pain and prepare for acute pain following surgery. Patients exhibited a great deal of trust in powerful others, expecting God and doctors to cure their pain through surgery. CONCLUSION: We note the importance of understanding a patient's individual pain coping mechanisms and identifying strategies to support these coping behaviors in pain management. Such an approach has the potential to reduce the burden of chronic arthritis pain while limiting reliance on opioids, particularly for patients who do not traditionally utilize powerful analgesics.


Assuntos
Artroplastia do Joelho/efeitos adversos , Dor Crônica/terapia , Osteoartrite do Quadril/complicações , Osteoartrite do Joelho/complicações , Manejo da Dor/métodos , Dor Pós-Operatória/terapia , Adaptação Psicológica , Adulto , Idoso , Analgésicos/uso terapêutico , Analgésicos Opioides/uso terapêutico , Artroplastia de Quadril , República Dominicana , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite do Quadril/psicologia , Osteoartrite do Quadril/cirurgia , Osteoartrite do Joelho/psicologia , Osteoartrite do Joelho/cirurgia , Período Pós-Operatório , Pesquisa Qualitativa , Religião , Adulto Jovem
18.
J Orthop Sci ; 20(6): 1098-105, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26307208

RESUMO

BACKGROUND: Before this work a Japanese version of the Toronto Extremity Salvage Score (TESS), a disease-specific patient-completed questionnaire widely used to assess the physical function of patients with musculoskeletal tumors, had not been developed. The purpose of this study was cross-cultural adaptation and validation of the English-language version of the TESS to facilitate international comparisons of treatment results. METHODS: The TESS was translated into Japanese, back-translated into English, and reviewed by a committee to develop a consensus Japanese version of the TESS. One hundred and two patients were assessed by use of this Japanese version to examine its reliability and validity. RESULTS: Test-retest reliability and internal consistency determined by using the intraclass correlation coefficient (0.941) and Cronbach's alpha test (0.978), respectively, were excellent. Factor analysis showed that the structure consisted of a three-item cluster; the Akaike information criterion (AIC) network also demonstrated that the items could be divided into three domains in accordance with their content. The Japanese version of the TESS correlated with the Musculoskeletal Tumor Society rating scale (r = 0.811; P < 0.001) and the Short Form-36 physical component summary (r = 0.785; P < 0.001). CONCLUSIONS: Our study suggested that the Japanese version of the TESS is a reliable and valid instrument for measuring patient-reported functional outcome for patients with lower extremity sarcoma, and that it enables international comparisons of treatment results. The spatial association of each item demonstrated by using the AIC network also suggested that the underlying structure of the TESS reflected its coverage of a wide range of physical functions.


Assuntos
Neoplasias Ósseas/patologia , Neoplasias Ósseas/cirurgia , Comparação Transcultural , Salvamento de Membro/métodos , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/cirurgia , Adaptação Psicológica , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Neoplasias Ósseas/mortalidade , Estudos Transversais , Análise Fatorial , Feminino , Humanos , Japão , Extremidade Inferior , Masculino , Pessoa de Meia-Idade , Ontário , Medição de Risco , Fatores Sexuais , Neoplasias de Tecidos Moles/mortalidade , Inquéritos e Questionários , Análise de Sobrevida , Traduções , Adulto Jovem
19.
Am J Sports Med ; 43(8): 1844-9, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26078452

RESUMO

BACKGROUND: There is minimal information available on the threshold at which patients consider themselves to be well for patient-reported outcome measures used in patients treated with hip arthroscopy for femoroacetabular impingement (FAI). PURPOSE: To determine the patient acceptable symptomatic state (PASS) for the modified Harris Hip Score (mHHS) and the Hip Outcome Score (HOS) in patients with FAI treated with arthroscopic hip surgery. STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 2. METHODS: A consecutive series of patients at a single institution with FAI who were treated with arthroscopic labral surgery, acetabular rim trimming, and femoral osteochondroplasty were eligible. The mHHS (score range, 0-100) and the HOS (score range, 0-100) were administered at baseline and at 12 months postoperatively. An external anchor question at 1 year postoperatively was utilized to determine PASS values: "Taking into account all the activities you have during your daily life, your level of pain, and also your functional impairment, do you consider that your current state is satisfactory?" RESULTS: There were 130 patients (mean ± SD age, 35.6 ± 11.7 years), and 42.3% were male. Based on a receiver operator curve analysis, the PASS values-at which patients considered their status to be satisfactory-at 1 year after surgery were 74 (mHHS), 87 (HOS-activities of daily living subscale), and 75 (HOS-sports subscale). The PASS threshold was not affected by baseline scores across different instruments. However, patients with higher baseline scores were more likely to achieve the PASS (odds ratios: 3.36 [mHHS], 3.83 [HOS-activities of daily living], 3.38 [HOS-sports]). Age and sex were not significantly related to the odds of achieving the PASS for the mHHS or the HOS. CONCLUSION: This is the first study to determine the PASS for 2 commonly used hip joint patient-reported outcome measures in patients undergoing surgery for FAI. The study findings can allow researchers to determine if interventions related to FAI are meaningful to patients at the individual level across various domains and will also be useful for responder analyses in future randomized trials related to hip arthroscopy and the treatment of FAI.


Assuntos
Artroscopia/métodos , Impacto Femoroacetabular/cirurgia , Fêmur/cirurgia , Articulação do Quadril/cirurgia , Atividades Cotidianas , Adulto , Estudos de Coortes , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Dor/epidemiologia , Período Pós-Operatório , Esportes , Resultado do Tratamento , Adulto Jovem
20.
Spine (Phila Pa 1976) ; 40(3): 171-8, 2015 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-25668335

RESUMO

STUDY DESIGN: Ambispective, retrospective cohort study from prospectively collected data. SUMMARY OF BACKGROUND DATA: Cervical spondylotic myelopathy is the commonest cause of spinal cord impairment in the elderly population worldwide. Although magnetic resonance imaging (MRI) is the primary imaging modality for confirming the diagnosis, its role in predicting surgical outcome remains unclear. METHODS: Two hundred seventy-eight patients with 1 or more clinical signs of myelopathy were enrolled; and they underwent decompression surgery. Complete baseline clinical and MRI data were available for 102 patients. MRI parameters measured included presence/absence of signal change on T1 and T2, T2 signal quantitative factors, and anatomical measurements. A dichotomized postoperative modified Japanese Orthopedic Association (mJOA) score at 6 months was used to characterize patients with mild myelopathy (≥16) and those with substantial residual neurological impairment (<16). Univariate analysis assessed the relationship between baseline parameters and outcome. Multivariate logistic regression was conducted after a conceptual division of variables into 3 groups: T1 signal analysis, T2 signal analysis, and anatomical measurements. RESULTS: Baseline mJOA (P<0.001; odds ratio [OR]=1.644, 95% confidence interval [95% CI]: 1.326-2.037), maximum canal compromise (MCC) (P=0.0322; OR=0.965, 95% CI: 0.934-0.997), T2 hyperintensity region of interest area (P=0.0422; OR=0.67; 95% CI: 0.456-0.986), and sagittal extent (P=0.026; OR=0.673; 95% CI: 0.475-0.954) were significantly associated with outcome univariately. The final model was comprised of T1 hypointensity (P=0.029; OR=0.242; CI: 0.068-0.866), MCC (P=0.005; OR=0.940; CI: 0.90-0.982) and baseline mJOA (P<0.001; OR=1.743; CI: 1.353-2.245), yielding an area under the receiver operating characteristic curve (AUC) of 0.845. CONCLUSION: Baseline mJOA is a strong predictor of postsurgical outcome in cervical spondylotic myelopathy at 6 months. However, a model inclusive of MCC and T1 hypointensity assessment provides superior predictive capacity. This suggests that MRI analysis has a significant role in predicting surgical outcome. LEVEL OF EVIDENCE: 3.


Assuntos
Vértebras Cervicais/patologia , Descompressão Cirúrgica , Espondilose/patologia , Adulto , Idoso , Vértebras Cervicais/cirurgia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Índice de Gravidade de Doença , Espondilose/cirurgia , Resultado do Tratamento
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