[Polymorphism of glutathion-S-transferase genes in patients with prostatic cancer].

The study of polymorphic variants of GSTT1, GSTM1 and GSTP1 genes from 61 patients with prostatic cancer (PC) has shown that incidence of 0/0 genotype GSTT1 and GSTM1 in PC patients was significantly higher of that in healthy men (n = 100) (34.4 and 15% in p = 0.007 and 60.7 and 43% in p = 0.04, respectively). PC risk in carriers of a GSTT1 deletion form was 2.97, CI95%--1.3-6.84, GSTM1--2.04 in CI95% 1.02-4.1. The analysis of combinations of pathological genotypes of xenobiotic biotransformation enzymes has demonstrated that 89.8% PC patients have a mutation in one of the genes GSTT1, GSTM1 or GSTP1.

[Cerebral metabolism and the exchange of biogenic amines in the brain of patients under various types of anesthesia in the surgery of intracranial aneurysms].

During intracranial surgical interventions, the major tasks of an anesthetic procedure are to maintain cerebral perfusion, adequate oxygen delivery, and brain tissue metabolism at all surgical stages. The authors have compared cerebral metabolism and the exchange of biogenic amines that regulate cerebral oxygen consumption and cerebral blood flow, by using neuroleptic anesthesia and balanced anesthesia on the basis of enflurane during operations on intracranial vessels. There is evidence for the equal efficiency of both types of anesthesias and for a unidirectional impact on the body's neurohumoral systems.

[Genetic polymorphism of glutathione-s-transferases theta1 and mu1 in lung cancer].

Polymorphism of GSTT1 and GSTM1 variant genes of phase II biotransformation of xenobiotics was studied in 181 patients with lung cancer. Null genotype frequency in cancer patients was higher than in healthy subjects. It was still higher in metastatic cancer disseminated to the regional lymph nodes as compared with localized tumor.

[Anesthetic support of operations on the hip joint in senile patients].

The impact of spinal anesthesia on a surgical stress response during prosthetic repair of the hip joint was studied in 56 senile patients (mean age 76 +/- 2.1 years). Hemodynamic changes, the time course of fluid distribution in different sectors, the activities of sympathoadrenal, cholinergic, serotoninergic, and histaminergic systems were analyzed. Studies were conducted in 4 steps: before a planned operation, before anesthesia, after the end of surgery, and 24 hours after intervention. The characteristic features of hemodynamic changes were elevated left ventricular filling pressure and high specific peripheral resistance, which was regarded as signs of latent heart failure and age-related vascular tone regulatory changes. Involutional tissue processes in senile patients appeared as decreased water levels in the cellular sector. The patients' sympathoadrenal and enterochromaffin systems were in a state of hypofunction. The adequacy of anesthesia supports no trend in the study neurohumoral regulatory parameters. The low level of hormones and mediators confirms the true depletion of the neurohumoral regulatory system.

[The system of neurohumoral regulation during bypass surgery without extracorporeal blood circulation]. / Sostoianie sistemy neirogumoral'noi reguliatsii organizma vo vremia operatsii koronarnogo shuntirovaniia bez iskusstvennogo krovoobrashcheniia.

The activity of sympathyco-adrenal, and of serotonin-hystain-cholinergic systems was studied in 34 patients operated for the ischemic heart disease without extracorporeal blood circulation. A moderate increase of parameters characterizing the condition of sympathyco-adrenal, and of serotonin-hystain-cholinergic systems was noted in patients in the perioperative period. The activity of the studied systems reduced due to a total anesthetization. At the same time, the activation of the factors of the neurohumoral system was limited by the adaptation norms with sufficient reserves being preserved.

[Epidemiologic features of hospital pyo-septic infection in a cardiosurgical hospital]. / Epidemiologicheskie osobennosti gospital'noi gnoino-septicheskoi infektsii v kardiokhirurgicheskom statsionare.

The results of the epidemiological analysis of morbidity in purulent septic infection in a cardiosurgical hospital during the period of 1990-1963 is presented. As revealed by this analysis, until 1993 the dominating causative agent of this infection was Pseudomonas aeruginosa O16, and since 1994 Staphylococcus epidermidis prevailed. The morbidity dynamics for several years and during individual years is shown. The main risk factors were established. The reanimation department was found to be the main areas where the contamination of patients occurred.

Changes of blood levels of several hormones, catecholamines, prostaglandins, electrolytes and cAMP in man during emotional stress.

The levels of several hormones (ACTH, GH, TSH, FSH, LH, parathyroid hormone--PTH, insulin, thyroxine--T4, triiodothyronine--T3, cortisol, testosterone, aldosterone, renin), catecholamines (epinephrine, norepinephrine, dopamin), prostaglandins (F1 alpha, F2 alpha, A + E), electrolytes (Na, K, Ca, Mg), cAMP and glucose in blood were measured before and immediately after the examination in 15 male students aged 28 to 35 years. Simultaneously the blood pressure was measured and hemodynamic measures were registered with the aid of echocardiography. A remarkable increase of catecholamines, ACTH, renin, T3, PTH, cAMP, PG F1 alpha, PG F2 alpha and Ca was found before the examination together with the increase of blood pressure. After the examination the levels of catecholamines, renin, aldosterone, T3, PTH, GH, FSH, LH, testosterone, PG A + E, glucose and Ca were found to be increased, while these of insulin, Na, PG F1 alpha, PG F2 alpha were decreased. The decrease of blood pressure was also found.