RESUMO
BACKGROUND AND OBJECTIVES: Rose bengal (RB) is a potent photosensitizer that has largely been overlooked as a potential photodynamic therapy (PDT) agent. In this study, the feasibility of topical delivery of RB to the epidermis has been evaluated. STUDY DESIGN/MATERIALS AND METHODS: Topical formulations of RB were assessed on murine and rabbit skin for pharmacokinetic properties, cutaneous toxicity, and photosensitization. RESULTS: Hydrophilic formulations (Assuntos
Corantes Fluorescentes/farmacologia
, Fotoquimioterapia/métodos
, Fármacos Fotossensibilizantes/farmacologia
, Rosa Bengala/farmacologia
, Pele/efeitos dos fármacos
, Pele/efeitos da radiação
, Administração Cutânea
, Animais
, Dermatite Fototóxica/etiologia
, Relação Dose-Resposta à Radiação
, Avaliação Pré-Clínica de Medicamentos
, Estudos de Viabilidade
, Feminino
, Corantes Fluorescentes/farmacocinética
, Masculino
, Camundongos
, Microscopia
, Fármacos Fotossensibilizantes/farmacocinética
, Coelhos
, Rosa Bengala/farmacocinética