The dynamic response of human lungs due to underwater shock wave exposure.

Since the 19th century, underwater explosions have posed a significant threat to service members. While there have been attempts to establish injury criteria for the most vulnerable organs, namely the lungs, existing criteria are highly variable due to insufficient human data and the corresponding inability to understand the underlying injury mechanisms. This study presents an experimental characterization of isolated human lung dynamics during simulated exposure to underwater shock waves. We found that the large acoustic impedance at the surface of the lung severely attenuated transmission of the shock wave into the lungs. However, the shock wave initiated large bulk pressure-volume cycles that are distinct from the response of the solid organs under similar loading. These pressure-volume cycles are due to compression of the contained gas, which we modeled with the Rayleigh-Plesset equation. The extent of these lung dynamics was dependent on physical confinement, which in real underwater blast conditions is influenced by factors such as rib cage properties and donned equipment. Findings demonstrate a potential causal mechanism for implosion injuries, which has significant implications for the understanding of primary blast lung injury due to underwater blast exposures.

Diagnostic value of knee arthrometry in the prediction of anterior cruciate ligament strain during landing.

BACKGROUND: Previous studies have indicated that higher knee joint laxity may be indicative of an increased risk of anterior cruciate ligament (ACL) injuries. Despite the frequent clinical use of knee arthrometry in the evaluation of knee laxity, little data exist to correlate instrumented laxity measures and ACL strain during dynamic high-risk activities. Purpose/ HYPOTHESES: The purpose of this study was to evaluate the relationships between ACL strain and anterior knee laxity measurements using arthrometry during both a drawer test and simulated bipedal landing (as an identified high-risk injurious task). We hypothesized that a high correlation exists between dynamic ACL strain and passive arthrometry displacement. The secondary hypothesis was that anterior knee laxity quantified by knee arthrometry is a valid predictor of injury risk such that specimens with greater anterior knee laxity would demonstrate increased levels of peak ACL strain during landing. STUDY DESIGN: Controlled laboratory study. METHODS: Twenty cadaveric lower limbs (mean age, 46 ± 6 years; 10 female and 10 male) were tested using a CompuKT knee arthrometer to measure knee joint laxity. Each specimen was tested under 4 continuous cycles of anterior-posterior shear force (±134 N) applied to the tibial tubercle. To quantify ACL strain, a differential variable reluctance transducer (DVRT) was arthroscopically placed on the ACL (anteromedial bundle), and specimens were retested. Subsequently, bipedal landing from 30 cm was simulated in a subset of 14 specimens (mean age, 45 ± 6 years; 6 female and 8 male) using a novel custom-designed drop stand. Changes in joint laxity and ACL strain under applied anterior shear force were statistically analyzed using paired sample t tests and analysis of variance. Multiple linear regression analyses were conducted to determine the relationship between anterior shear force, anterior tibial translation, and ACL strain. RESULTS: During simulated drawer tests, 134 N of applied anterior shear load produced a mean peak anterior tibial translation of 3.1 ± 1.1 mm and a mean peak ACL strain of 4.9% ± 4.3%. Anterior shear load was a significant determinant of anterior tibial translation (P < .0005) and peak ACL strain (P = .04). A significant correlation (r = 0.52, P < .0005) was observed between anterior tibial translation and ACL strain. Cadaveric simulations of landing produced a mean axial impact load of 4070 ± 732 N. Simulated landing significantly increased the mean peak anterior tibial translation to 10.4 ± 3.5 mm and the mean peak ACL strain to 6.8% ± 2.8% (P < .0005) compared with the prelanding condition. Significant correlations were observed between peak ACL strain during simulated landing and anterior tibial translation quantified by knee arthrometry. CONCLUSION: Our first hypothesis is supported by a significant correlation between arthrometry displacement collected during laxity tests and concurrent ACL strain calculated from DVRT measurements. Experimental findings also support our second hypothesis that instrumented measures of anterior knee laxity predict peak ACL strain during landing, while specimens with greater knee laxity demonstrated higher levels of peak ACL strain during landing. CLINICAL RELEVANCE: The current findings highlight the importance of instrumented anterior knee laxity assessments as a potential indicator of the risk of ACL injuries in addition to its clinical utility in the evaluation of ACL integrity.

Suture capsulorrhaphy versus capsulolabral advancement for shoulder instability.

PURPOSE: The purpose of this study was to test the strength of a suture capsulorrhaphy repair versus a capsulolabral repair with knotless suture anchors in a cadaveric model with anteroinferior shoulder instability. METHODS: Fourteen cadaveric shoulders were tested with either a suture capsulorrhaphy to the intact labrum or a capsulolabral advancement using a knotless suture anchor into the glenoid. Specimens were translated with the shoulder in an abducted, externally rotated position to failure. RESULTS: The capsulolabral advancement showed a significantly higher load to failure than did the suture capsulorrhaphy group (P = .030). CONCLUSIONS: Capsulolabral advancement with suture anchors may offer greater initial strength when compared with a suture capsulorrhaphy. In the setting of shoulder instability without evidence of a labral tear, the capsulolabral advancement technique may be considered biomechanically superior. CLINICAL RELEVANCE: In the setting of shoulder instability due to capsular insufficiency, the capsulolabral advancement may be considered biomechanically superior to a traditional suture capsulorrhaphy.

Distractive force relative to initial graft compression in an in vivo anterior cervical discectomy and fusion model.

STUDY DESIGN: An in vivo biomechanical anterior cervical discectomy and instrumented fusion (ACDFI) model employing a calibrated distractor and a subminiature load cell used to intraoperatively measure distractive force across the discectomy site and subsequent compressive force across the interbody load cell following distractor removal. OBJECTIVE: To determine the relationship between the distractive force and resultant initial graft compression in an in vivo ACDFI model. SUMMARY OF BACKGROUND DATA: The relationship between the distractive force and subsequent graft compression following distractor removal has not been studied in an in vivo ACDFI model. The consequences of over or under distraction and its subsequent effect on graft compression with regards to axial neck pain, endplate failure with graft subsidence, and fusion rates is an area of clinical significance for ACDFI. METHODS: Intraoperative measurements were obtained from 17 discectomy sites in 12 patients undergoing one and two level ACDFI. Informed consent was obtained from all subjects before surgery. A calibrated Caspar distractor was used to measure the distraction across the discectomy site and a subminiature interbody load cell was placed into the discectomy site and used to measure the resultant initial compressive force following distractor removal. The statistical significance and correlation between the distractive force across the discectomy site and the subsequent compressive force across the load cell were investigated with the Pearson correlation coefficient. RESULTS: The average distractive force across the discectomy site was 33.5 +/- 11.6 lbs and the subsequent compressive force across the interbody load cell was 16.9 +/- 5.9 lbs following distractor removal. The Pearson correlation coefficient was r = 0.912 (P < 0.0005). The data showed a statistically significant linear correlation between the distractive force and the subsequent compressive force across the range of distraction investigated. CONCLUSION: This study demonstrated a statistically significant linear correlation between the distractive force applied across the discectomy site and the subsequent compressive force across a load cell placed in the interbody space following distractor removal in an in vivo ACDFI model.

Predicting the effects of knee focal articular surface injury with a patient-specific finite element model.

Successful focal articular surface injury (FAI) repair depends on appropriate matching of the geometrical/material properties of the repaired site, and on the overall dynamic response of the knee to in-vivo loading. There is evidence linking the pathogenesis of lesion progression (e.g. osteoarthritis) to weightbearing site and defect size. The paper investigates further this link by studying the effects of osteochondral defect size on the load distribution at the human knee. Experimental data from cadaver knees (n=8) loaded at 30 degrees of flexion was used as input to a validated finite element (FE) model. Contact pressure was assessed for the intact knees and over a range of circular osteochondral defects (5 mm to 20 mm) at 30 degrees of flexion with 700 N axial load. Patient specific FE models and the specific boundary conditions of the experimental set-up were used to analyze the osteochondral defects. Stress concentration around the rims of defects 8 mm and smaller was not significant and pressure distribution was dominated by the menisci. Experimental data was confirmed by the model. For defects 10 mm and greater, distribution of peak pressures followed the rim of the defect with a mean distance from the rim of 2.64 mm on the medial condyle and 2.90 mm on the lateral condyle (model predictions were 2.63 and 2.87 mm respectively). Statistical significance was reported when comparing defects that differed by 4 mm or greater (except for the 5 mm case). Peak rim pressure did not significantly increase as defects were enlarged from 10 mm to 20 mm. Peak values were always significantly higher over the medial femoral condyle. Although the decision to treat osteochondral lesions is multifactorial, the results of this finite element analysis indicate that a size threshold of 10 mm, may be a useful early adjunct to guide clinical decision-making. This modified FE method can be employed for in-vivo studies.

Failure of coracoclavicular artificial graft reconstructions from repetitive rotation.

PURPOSE: To assess how suture type and suture construct in an augmented Weaver-Dunn reconstruction affect coracoclavicular sling failure and rotary stability. METHODS: Fifteen cadaveric shoulders were tested in rotation about the long axis of the clavicle with 10 lb of simulated arm weight. The clavicle was rotated 50 degrees about its long axis, and the applied torque was recorded. Next, modified Weaver-Dunn reconstruction was conducted. Two types of coracoclavicular sling (opposed drill holes through the clavicle and complete loop around the clavicle) were tested by use of 3 different sutures (FiberWire [Arthrex, Naples, FL], Mersilene tape [Ethicon, Somerville, NJ], and braided polydioxanone [PDS] [Ethicon]). For each sling-suture combination, the joint was retested over 50 degrees of rotation and then cycled over 40 degrees of rotation for 15,000 cycles or until failure. RESULTS: After modified Weaver-Dunn reconstruction with either sling construct, mean torque over 50 degrees of acromioclavicular rotation was significantly reduced in posterior (P < .0001) and anterior (P < .0001) rotation, with any suture material tested. When the coracoclavicular sling was placed through opposed drill holes, no wear to the bone or suture was observed. When the sling material was looped around the clavicle, FiberWire and PDS resulted in abrasion of soft tissue and periosteum. In all cases sawing motion between bone and suture was observed at the coracoid. The FiberWire itself failed at a mean of 8,213 cycles. Some wear was noted in the Mersilene tape. PDS suture showed no wear. CONCLUSIONS: In a cadaveric model of modified Weaver-Dunn reconstruction, a coracoclavicular suture loop was used to augment coracoacromial ligament transfer. Suture loops secured around the entire clavicle were shown to contribute to increased abrasive wear. Securing suture loops through opposed drill holes in the clavicle resulted in decreased abrasive wear. CLINICAL RELEVANCE: Proper selection of suture type and suture construct may affect the failure rate of augmented Weaver-Dunn reconstructions.

Biomechanical evaluation of parasagittal occipital plating: screw load sharing analysis.

STUDY DESIGN: Biomechanical evaluation of occipitocervical instrumentation techniques. OBJECTIVE: Compare methods of occipital instrumentation by quantifying load sharing of occipital screws and measuring motion across instrumented occipitocervical spines. SUMMARY OF BACKGROUND DATA: Newer occipitocervical plate/screw systems that attach to longitudinal rods have been developed to improve fixation. These devices place screws in the center of occipital bone or off-midline. Midline plates offer screw purchase in thicker bone. Off-midline systems may increase the effective moment arm for torsional and lateral bending control. Measurement of screw loads within occipital plates is useful for determining optimal plate configuration. METHODS: Ten cadaveric specimens (occiput-C4) were tested in flexion/extension (FE), lateral bending (LAT), and axial rotation (ROT) over +/-3 Nm pure moment. After intact testing, 4 occipitocervical fixation constructs were tested using washer load cells to assess loading across screws used to fix the plates to the occiput. Parasagittal occipital plates were positioned either convex or concave side facing medially. Each plate was first fixed using 3 screws (rostral, middle, caudal), then with the caudal screw eliminated (simulated failure). Range of motion (ROM) and peak screw loads are reported. RESULTS: ROM decreased from intact to any of the 4 fusion plate configurations in FE, LAT, and ROT (P << 0.05), but not between plate configurations. Screw load significantly decreased from medially convex to medially concave configurations in LAT, but no significant changes were observed in FE or ROT. With caudal screws removed, middle screws peak loads significantly increased in FE and LAT (P < 0.05), but not ROT. CONCLUSION: Occipital screw placement off-midline improves screw loads under lateral bending forces on occipitocervical constructs, though loads for FE and ROT are unchanged. As screws pullout, the loads may be redistributed, resulting in increased screw pullout forces above. Despite the improvement in screw loads for laterally based plates during lateral bending, overall ROM across the occipitocervical junction is unchanged.

Dynamic evaluation of contact pressure and the effects of graft harvest with subsequent lateral release at osteochondral donor sites in the knee.

PURPOSE: To dynamically evaluate contact pressure about the periphery of the lateral femoral condyle in intact knees, to qualify the effects of osteochondral donor graft harvest on this contact pressure, and to quantify the effects of lateral release on contact pressure after graft harvest. TYPE OF STUDY: Cadaveric analysis. METHODS: Digital electronic pressure-sensing cells were used to measure contact pressure over the periphery of the lateral femoral condyle in 10 fresh-frozen knee specimens. Nonweightbearing resistive extension was simulated as the knees were placed through a functional range of motion. Dynamic pressure readings were evaluated over intact cartilage, around the rims of four 5-mm osteochondral defects, and after lateral release. RESULTS: The pressure cells were all subjected to contact pressures as the knees were placed through a functional range of motion. Average maximal contact pressure progressed distally as the knees were flexed. The creation of 5-mm osteochondral defects did not lead to a significant increase in rim stress concentration over the surrounding cartilage. Lateral release resulted in small decreases in contact pressure over the osteochondral defects. CONCLUSIONS: The creation of 5-mm donor defects about the lateral aspect of the lateral femoral condyle does not lead to significant alterations in local contact pressure. CLINICAL RELEVANCE: Our biomechanical findings may have important implications relating to cartilage restoration using osteochondral autografting procedures. Donor-site morbidity may be minimized if donor-site defects are limited to 5 mm and smaller.

Osteochondral defects in the human knee: influence of defect size on cartilage rim stress and load redistribution to surrounding cartilage.

PURPOSE: To determine the influence of osteochondral defect size on defect rim stress concentration, peak rim stress, and load redistribution to adjacent cartilage over the weightbearing area of the medial and lateral femoral condyles in the human knee. METHODS: Eight fresh-frozen cadaveric knees were mounted at 30 degrees of flexion in a materials testing machine. Digital electronic pressure sensors were placed in the medial and lateral compartments of the knee. Each intact knee was first loaded to 700 N and held for 5 seconds. Dynamic pressure readings were recorded throughout the loading and holding phases. Loading was repeated over circular osteochondral defects (5, 8, 10, 12, 14, 16, 18, and 20 mm) in the 30 degrees weightbearing area of the medial and lateral femoral condyles. RESULTS: Stress concentration around the rims of defects 8 mm and smaller was not demonstrated, and pressure distribution in this size range was dominated by the menisci. For defects 10 mm and greater, distribution of peak pressures followed the rim of the defect with a mean distance from the rim of 2.2 mm on the medial condyle and 3.2 mm on the lateral condyle. An analysis of variance with Bonferroni correction revealed a statistically significant trend of increasing radius of peak pressure as defect size increased for defects from 10 to 20 mm (P = .0011). Peak rim pressure values did not increase significantly as defects were enlarged from 10 to 20 mm. Load redistribution during the holding phase was also observed. CONCLUSIONS: Rim stress concentration was demonstrated for osteochondral defects 10 mm and greater in size. This altered load distribution has important implications relating to the long-term integrity of cartilage adjacent to osteochondral defects in the human knee. Although the decision to treat osteochondral lesions is certainly multifactorial, a size threshold of 10 mm, based on biomechanical data, may be a useful adjunct to guide clinical decision making.