1.
Molecules
; 14(12): 5223-34, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20032888
RESUMO
Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo [4,5]imidazo[1,2-alpha]pyrimidin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the alkylation gave 10-alkyl derivatives which permitted the parallel generation of a 500-member library of the title compounds.
Assuntos
Antineoplásicos/química , Pirimidinonas/química , Alquilação , Espectroscopia de Ressonância Magnética
2.
J Comb Chem
; 9(6): 909-11, 2007.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17727267