RESUMO
We report a case of enterovirus related pericarditis associated to mediastinitis in a hospitalised 53-year-old male after heart surgery. Mediastinitis caused by enterovirus has not previously been described.
Assuntos
Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Infecções por Enterovirus , Mediastinite/virologia , Pericardite/virologia , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Recently, mutations in the X-linked ubiquitin protease 26 (USP26) gene have been proposed to be associated with male infertility. In particular a 371insACA, 494T>C and 1423C>T haplotype, which results in a T123-124ins, L165S and H475Y amino acid change respectively, has been reported to be associated with Sertoli cell-only syndrome (SCOS) and an absence of sperm in the ejaculate. Here, we demonstrate that two of these changes actually correspond to the ancestral sequence of the gene and that the USP26 haplotype is present in significant frequencies in sub-Saharan African and South and East Asian populations, including in individuals with known fertility. This indicates that the allele is not associated with infertility. The pattern of frequency distribution of the derived haplotype (371delACA, 494T), which is present at high frequencies in most non-African populations could be interpreted as either a result of migration followed by simple genetic drift or alternatively as positive selection acting on the derived alleles. The latter hypothesis seems likely, because there is evidence of strong positive selection acting on the USP26 gene.
Assuntos
Cisteína Endopeptidases/genética , Fertilidade/genética , Haplótipos , Mutação , Testículo/enzimologia , África Subsaariana , Sudeste Asiático , Evolução Molecular , Frequência do Gene , Deriva Genética , Genética Populacional , Humanos , Infertilidade Masculina/genética , MasculinoRESUMO
We report about a patient presenting with a mixed acid-base disorder. His blood gas analysis showed a metabolic acidosis caused by renal failure and lactic acidosis combined with a hypochloraemic alkalosis. The underlying pathology was a cystic dystrophy of aberrant pancreatic tissue leading to excessive vomiting, extracellular dehydration with a renal failure and hypochloraemia.
Assuntos
Desequilíbrio Ácido-Base/etiologia , Cisto Pancreático/complicações , Cisto Pancreático/diagnóstico , Desequilíbrio Ácido-Base/diagnóstico por imagem , Acidose/etiologia , Injúria Renal Aguda/complicações , Adulto , Alcalose/etiologia , Análise Química do Sangue , Gasometria , Desidratação/etiologia , Humanos , Ácido Láctico/sangue , Masculino , Cisto Pancreático/diagnóstico por imagem , Ultrassonografia , Vômito/etiologiaRESUMO
OBJECTIVE: Oestrogen withdrawal has been hypothesized as playing a causal role in puerperal psychoses. However, oestrogen withdrawal exists in conditions others than puerperium. We searched the published case reports where a decrease in oestrogen levels not occurring during puerperium was associated with a psychotic disorder, in order to evaluate the relevance of this hypothesis. These cases were defined as oestrogen withdrawal associated psychoses. METHOD: A systematic research of the literature was conducted for the period 1960-2000. RESULTS: We identified 26 observations reporting an association between a psychotic disorder and a phase of oestrogen withdrawal. Psychotic episodes were short and reversible with recurrences reported when oestrogen withdrawal recurred. Puerperal psychosis was frequently reported in the history of patients. CONCLUSION: The oestrogen withdrawal hypothesis can be extended to certain psychotic episodes not occurring during in puerperium. This provides an additional argument for the clinical relevance of oestrogen withdrawal in puerperal and related psychoses.