Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant.

The huge worldwide demand for vaccines targeting SARS-CoV-2 has necessitated the continued development of novel improved formulations capable of reducing the burden of the COVID-19 pandemic. Herein, we evaluated novel protein subunit vaccine formulations containing a resistin-trimerized spike antigen, SmT1. When combined with sulfated lactosyl archaeol (SLA) archaeosome adjuvant, formulations induced robust antigen-specific humoral and cellular immune responses in mice. Antibodies had strong neutralizing activity, preventing viral spike binding and viral infection. In addition, the formulations were highly efficacious in a hamster challenge model reducing viral load and body weight loss even after a single vaccination. The antigen-specific antibodies generated by our vaccine formulations had stronger neutralizing activity than human convalescent plasma, neutralizing the spike proteins of the B.1.1.7 and B.1.351 variants of concern. As such, our SmT1 antigen along with SLA archaeosome adjuvant comprise a promising platform for the development of efficacious protein subunit vaccine formulations for SARS-CoV-2.

DNA Based Vaccine Expressing SARS-CoV-2 Spike-CD40L Fusion Protein Confers Protection Against Challenge in a Syrian Hamster Model.

SARS-CoV-2 infections present a tremendous threat to public health. Safe and efficacious vaccines are the most effective means in preventing the infections. A variety of vaccines have demonstrated excellent efficacy and safety around the globe. Yet, development of alternative forms of vaccines remains beneficial, particularly those with simpler production processes, less stringent storage conditions, and the capability of being used in heterologous prime/boost regimens which have shown improved efficacy against many diseases. Here we reported a novel DNA vaccine comprised of the SARS-CoV-2 spike protein fused with CD40 ligand (CD40L) serving as both a targeting ligand and molecular adjuvant. A single intramuscular injection in Syrian hamsters induced significant neutralizing antibodies 3-weeks after vaccination, with a boost substantially improving immune responses. Moreover, the vaccine also reduced weight loss and suppressed viral replication in the lungs and nasal turbinates of challenged animals. Finally, the incorporation of CD40L into the DNA vaccine was shown to reduce lung pathology more effectively than the DNA vaccine devoid of CD40L. These results collectively indicate that this DNA vaccine candidate could be further explored because of its efficacy and known safety profile.

Formación en salud mental en psicología, trabajo social, medicina, enfermería y terapia ocupacional en Colombia / Training in mental health in psychology, social work, medicine, nursing and occupational therapy in colombia / Formação em saúde mental em psicología, trabalho social, medicina, enfermagem e terapia ocupacional na Colômbia

Este artículo presenta los resultados de una investigación que tuvo como objetivo analizar el componente de salud mental presente en las mallas curriculares de los programas universitarios de psicología, trabajo social, medicina, enfermería y terapia ocupacional en Colombia, 2015. Se trata de un estudio cualitativo descriptivo, para el cual se hizo uso de fuentes documentales, como las mallas curriculares de los programas y la información descriptiva de los mismos ofrecidas en sus páginas web, y de un grupo de discusión con representantes de las disciplinas en cuestión; participaron 321 programas universitarios que para 2015 se encontraban activos en el Sistema Nacional de Información de la Educación Superior. Se encuentra que la formación en salud mental no es tema de interés explícito en los planes de formación curricular, constituyéndose por lo tanto en un contenido abordado dentro de otros temas más generales, lo que permite concluir que los retos para la formación en salud mental que se infieren de la ley colombiana de salud mental, no son acogidos suficientemente.

This article presents the results of a research that aimed at analyzing the mental health component present in the curriculum of the Psychology, Social Work, Medicine, Nursing and Occupational Therapy university programs in Colombia, in 2015. It is a descriptive qualitative study, for which documentary sources were used such as the curriculum of the programs and the descriptive information offered on their web pages, and a discussion group with representatives of the disciplines in question. A total of 321 university programs that by 2015 were active in the National Information System of Higher Education participated in the study. It was found that training in mental health is not a topic of explicit interest in curricular training plans, thus constituting a content addressed within other more general topics, which allows concluding that the challenges for training in mental health inferred from the Colombian Mental Health Law, are not sufficiently spread.

Este artigo apresenta os resultados duma pesquisa que teve como objetivo analisar o componente de saúde mental presente nas matrizes curriculares dos programas universitários de psicologia, trabalho social, medicina, enfermagem e terapia ocupacional na Colômbia, 2015. Trata-se dum estudo qualitativo descritivo, para o qual se fez uso de fontes documentais, como as matrizes curriculares dos programas e a informação descritiva das mesmas oferecidas em suas páginas web, e dum grupo de discussão com representantes das disciplinas em questão; participaram 321 programas universitários que para 2015 se encontravam ativos no Sistema Nacional de Informação da Educação Superior. Encontra-se que a formação em saúde mental não é tema de interesse explícito nos planos de formação curricular, constituindo-se portanto em um conteúdo abordado dentro de outros temas mais gerais, o que permite concluir que os retos para a formação em saúde mental que se inferem da lei colombiana de saúde mental, não são aceitados suficientemente.

Formación en salud mental en psicología, trabajo social, medicina, enfermería y terapia ocupacional en Colombia / Training in mental health in psychology, social work, medicine, nursing and occupational therapy in Colombia / Formação em saúde mental em psicología, trabalho social, medicina, enfermagem e terapia ocupacional na Colômbia

Resumen Este artículo presenta los resultados de una investigación que tuvo como objetivo analizar el componente de salud mental presente en las mallas curriculares de los programas universitarios de psicología, trabajo social, medicina, enfermería y terapia ocupacional en Colombia, 2015. Se trata de un estudio cualitativo descriptivo, para el cual se hizo uso de fuentes documentales, como las mallas curriculares de los programas y la información descriptiva de los mismos ofrecidas en sus páginas web, y de un grupo de discusión con representantes de las disciplinas en cuestión; participaron 321 programas universitarios que para 2015 se encontraban activos en el Sistema Nacional de Información de la Educación Superior. Se encuentra que la formación en salud mental no es tema de interés explícito en los planes de formación curricular, constituyéndose por lo tanto en un contenido abordado dentro de otros temas más generales, lo que permite concluir que los retos para la formación en salud mental que se infieren de la ley colombiana de salud mental, no son acogidos suficientemente.

Abstract This article presents the results of a research that aimed at analyzing the mental health component present in the curriculum of the Psychology, Social Work, Medicine, Nursing and Occupational Therapy university programs in Colombia, in 2015. It is a descriptive qualitative study, for which documentary sources were used such as the curriculum of the programs and the descriptive information offered on their web pages, and a discussion group with representatives of the disciplines in question. A total of 321 university programs that by 2015 were active in the National Information System of Higher Education participated in the study. It was found that training in mental health is not a topic of explicit interest in curricular training plans, thus constituting a content addressed within other more general topics, which allows concluding that the challenges for training in mental health inferred from the Colombian Mental Health Law, are not sufficiently spread.

Resumo Este artigo apresenta os resultados duma pesquisa que teve como objetivo analisar o componente de saúde mental presente nas matrizes curriculares dos programas universitários de psicologia, trabalho social, medicina, enfermagem e terapia ocupacional na Colômbia, 2015. Trata-se dum estudo qualitativo descritivo, para o qual se fez uso de fontes documentais, como as matrizes curriculares dos programas e a informação descritiva das mesmas oferecidas em suas páginas web, e dum grupo de discussão com representantes das disciplinas em questão; participaram 321 programas universitários que para 2015 se encontravam ativos no Sistema Nacional de Informação da Educação Superior. Encontra-se que a formação em saúde mental não é tema de interesse explícito nos planos de formação curricular, constituindo-se portanto em um conteúdo abordado dentro de outros temas mais gerais, o que permite concluir que os retos para a formação em saúde mental que se inferem da lei colombiana de saúde mental, não são aceitados suficientemente.

Transdisciplinariedad en salud mental: Una propuesta de modelo de formación / Transdisciplinarity in mental health: A proposal of training model

Este artículo presenta los resultados de una investigación que tuvo como objetivo diseñar una propuesta de Modelo de Formación Transdisciplinar en Salud Mental para cuatro programas universitarios en la región de Antioquia (Colombia), con el propósito de contribuir al mejoramiento de esta formación en los profesionales de Psicología, Enfermería, Trabajo Social y Medicina. El estudio tuvo un enfoque cualitativo de tipo documental, aplicado y hermenéutico, que propició la participación de formadores, empleadores y profesionales de las nueve subregiones de Antioquia. Como estrategias de recolección de información, se realizó revisión documental y entrevistas semiestructuradas; se hizo análisis categorial a través de Nvivo, y finalmente se realizó un ejercicio de validación por medio de mesas de trabajo con informantes de la investigación. El desarrollo de la investigación permitió que los informantes pudieran dar cuenta de los principales eventos en salud mental de sus contextos, las necesidades de formación del recurso humano que los acompaña y de algunas estrategias para la formación profesional de este talento humano. Igualmente, se identificaron y describieron los principales eventos en salud mental que son reportados en medios oficiales del Departamento de Antioquia. En conclusión, se da lugar a la construcción del documento que presenta la Propuesta de Modelo de Formación Transdisciplinar en Salud Mental para cuatro programas de pregrado en Antioquia, que incluye modalidades de aplicación que bien pueden acogerse por los diferentes programas en su formación curricular y/o complementaria.

This article presents the results of a research that aimed to design a proposal of a Transdisciplinary Training Model for Mental Health (MH) for 4 Undergraduate Programs in the department (state) of Antioquia (Colombia), with the purpose of contributing to the improvement of the training for the professionals of Psychology, Nursing, Social Work and Medicine. The study had a qualitative approach of an applied, hermeneutic and documenting type, whose data collection strategies consisted of documentary review and semi-structured interviews. Under the first strategy the disciplinary objects of Psychology, Nursing, Social Work and Medicine were reviewed, which allowed the description of the objects of each discipline, the identification of points of convergence and therefore of the interdisciplinary and transdisciplinary possibilities. Likewise, we proceeded with the reading of some reports provided by government entities, responsible for ensuring the health and mental health of the inhabitants of Antioquia, to recognize the main events in MH reported in the state. After the documentary review, semi-structured interviews were conducted with different actors involved with the MH: trainers, employers and professionals from the nine subregions of Antioquia; therefore, there were three different interview scripts. Once the interviews were conducted, they were subjected to a categorical analysis through Nvivo. Finally, in a public event with the participants of the research a validation exercise of The Training Model Proposal was carried out, there the results obtained at that point were socialized, so that it was debated in small groups and feedbacks were given. These feedbacks were considered for the final formulation of the Transdisciplinary Training Model Proposal. The development of the research allowed the Interviewed people to account for the more significant mental health events in their areas, as well as the training needs of the human resource that go along with these events and, some strategies for the professional training of this human talent. Likewise, the more significant events in mental health that are reported in official media of the Department of Antioquia were identified and described. Based on these results, the conceptualization of MH was considered for the Thematic Component of the Proposal, training in the clinical area, which in turn implies training in psychopathology, psychiatric patient care and intervention strategies; courses oriented to the understanding and intervention of violence, consumption of Psychoactive Substances, family MH and community MH; knowledge in mental health care procedures, primary care in MH and different approaches to care in MH, such as psychosocial, social determinants of MH and differential approaches, especially the life cycle in relation to childhood and adolescence; Emphasis is also placed on the importance of training in public policies, public health and the functioning of the General Social Security and Health System. It takes place the creation of the document that presents the Proposal for a Model of Transdisciplinary Training in Mental Health for 4 Undergraduate Programs in Antioquia; this proposal includes modalities of application that can be accepted by the different programs in their curricular and/or complementary training. The curricular training, whose topics are stated in the results, must be accompanied by the strengthening of competencies associated with the ability to read contextualized MH issues, which contribute to interventions closer to the reality of the population; as well as, to attend to aspects related to the student's being, oriented to an ethical reflection, to the MH of the student and to the strengthening of their vocation.

Doble aneuploidía en un niño colombiano: síndrome de Down-Klinefelter, con fenotipo de síndrome de Down / Double aneuploidy in a Colombian child: Down-Klinefelter syndrome with Down syndrome phenotype

La ocurrencia de una doble aneuploidía en una misma persona es un evento relativamente raro. Se presenta el caso de un niño de siete meses de edad, de padres no consanguíneos con características clínicas de síndrome de Down y cariotipo 48XXY.

The occurrence of double aneuploidy in one person is a relatively rare phenomenon. We report the case of a 7-month-old child, the third-born of non-consanguineous parents, with clinical features of Down syndrome and karyotype 48XXY.

Conjuntivitis alérgica / Allergic conjunctivitis

Se presenta una revisión de ''Conjuntivitis Alérgica" haciendo un repaso inicial de la anatomía funcional de la conjuntiva, definición de términos, revisando los signos y síntomas principales para estudiar finalmente cada tipo de conjuntivitis alérgica en forma independiente, los mecanismos inmunológicos y las posibilidades terapéuticas existentes.