RESUMO
Positron emission tomography (PET)-magnetic resonance (MR) or single photon emission computed tomography (SPECT)-MR hybrid imaging is being used in daily clinical practice. Due to its advantages over stand-alone PET, SPECT or MR imaging, in many areas such as oncology, the demand for hybrid imaging techniques is increasing dramatically. The use of multimodal imaging probes or biomarkers in a single molecule or particle to characterize the imaging subjects such as disease tissues certainly provides us with more accurate diagnosis and promotes therapeutic accuracy. A limited number of multimodal imaging probes are being used in preclinical and potential clinical investigations. The further development of multimodal PET-MR and SPECT-MR imaging probes includes several key elements: novel synthetic strategies, high sensitivity for accurate quantification and high anatomic resolution, favourable pharmacokinetic profile and target-specific binding of a new probe. This review thoroughly summarizes all recently available and noteworthy PET-MR and SPECT-MR multimodal imaging probes including small molecule bimodal probes, nano-sized bimodal probes, small molecular trimodal probes and nano-sized trimodal probes. To the best of our knowledge, this is the first comprehensive overview of all PET-MR and SPECT-MR multimodal probes. Since the development of multimodal PET-MR and SPECT-MR imaging probes is an emerging research field, a selection of 139 papers were recognized following the literature review. The challenges for designing multimodal probes have also been addressed in order to offer some future research directions for this novel interdisciplinary research field.
Assuntos
Imageamento por Ressonância Magnética/métodos , Sondas Moleculares/química , Imagem Multimodal/métodos , Tomografia por Emissão de Pósitrons/métodos , Tomografia Computadorizada de Emissão de Fóton Único/métodos , Animais , Humanos , Imageamento por Ressonância Magnética/instrumentação , Imagem Multimodal/instrumentação , Tomografia por Emissão de Pósitrons/instrumentação , Tomografia Computadorizada de Emissão de Fóton Único/instrumentaçãoRESUMO
Sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease is a rare clinicopathological entity that typically affects young adults, with patients presenting frequently with fever and painless cervical adenopathy. It can mimic lymphoproliferative diseases, and FDG PET/CT typically demonstrates significant FDG avidity in areas of disease. We report a case of a young Chinese woman presenting with pyrexia and painless cervical adenopathy, for which FDG PET/CT performed as part of the diagnostic process demonstrated FDG avid lesions in both nodal and extranodal sites.
Assuntos
Febre/complicações , Fluordesoxiglucose F18 , Histiocitose Sinusal/diagnóstico por imagem , Doenças Linfáticas/complicações , Tomografia por Emissão de Pósitrons , Tomografia Computadorizada por Raios X , Feminino , Histiocitose Sinusal/complicações , Humanos , Adulto JovemRESUMO
This case demonstrates the utility of performing F-18 fluorodeoxyglucose positron emission tomography/computed tomography for the investigation of an unresolving pulmonary embolus, where early diagnosis of tumor thrombus or primary neoplastic conditions of the pulmonary artery may be made. Choriocarcinoma presenting within the pulmonary artery is rare although a literature review shows that a number of important differential diagnoses of hypermetabolic pulmonary lesions should be kept in mind.
Assuntos
Coriocarcinoma/diagnóstico por imagem , Fluordesoxiglucose F18 , Tomografia por Emissão de Pósitrons , Embolia Pulmonar/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-IdadeAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Arritmias Cardíacas/etiologia , Neoplasias Cardíacas/complicações , Neoplasias Cardíacas/tratamento farmacológico , Células Matadoras Naturais , Linfoma de Células T/tratamento farmacológico , Neoplasias Nasais/patologia , Tomografia por Emissão de Pósitrons , Idoso , Meios de Contraste , Fluordesoxiglucose F18 , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/secundário , Humanos , Linfoma de Células T/diagnóstico por imagem , Linfoma de Células T/patologia , Masculino , Neoplasias Nasais/tratamento farmacológico , Tomografia por Emissão de Pósitrons/métodos , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
Iodine-131 whole-body scintigraphy has been used extensively to detect thyroid remnants as well as metastatic disease in thyroid carcinoma postthyroidectomy. Over the years, numerous causes of false-positive scans have been reported. The authors report a novel case of a false-positive result resulting from a subdural hematoma mimicking a skull or cerebral metastasis.