Hepatoprotective Mechanisms Induced by Spinach Methanolic Extract in Rats with Hyperglycemia-An Immunohistochemical Analysis.

Spinach methanolic extract (SME) has a hepatoprotective effect due to its polyphenolic antioxidants; however, its action in parenchymal (PQ) and non-parenchymal (nPQ) cells remains unknown. This study investigates the hepatoprotective effect of SME on streptozotocin-induced hyperglycemic rats (STZ), focusing on immunohistochemical analyses. Methods: The extract was prepared, and the total polyphenols and antioxidant activity were quantified. Adult male Wistar rats were divided into four groups (n = 8): normoglycemic rats (NG), STZ-induced hyperglycemic (STZ), STZ treated with 400 mg/kg SME (STZ-SME), and NG treated with SME (SME) for 12 weeks. Serum liver transaminases and lipid peroxidation levels in tissue were determined. The distribution pattern and relative levels of markers related to oxidative stress [reactive oxygen species (ROS), superoxide dismutase-1, catalase, and glutathione peroxidase-1], of cytoprotective molecules [nuclear NRF2 and heme oxygenase-1 (HO-1)], of inflammatory mediators [nuclear NF-κB, TNF-α], proliferation (PCNA), and of fibrogenesis markers [TGF-ß, Smad2/3, MMP-9, and TIMP1] were evaluated. Results: SME had antioxidant capacity, and it lowered serum transaminase levels in STZ-SME compared to STZ. It reduced NOX4 staining, and lipid peroxidation levels were related to low formation of ROS. In STZ-SME, the immunostaining for antioxidant enzymes increased in nPQ cells compared to STZ. However, enzymes were also localized in extra and intracellular vesicles in STZ. Nuclear NRF2 staining and HO-1 expression in PQ and nPQ were higher in STZ-SME than in STZ. Inflammatory factors were decreased in STZ-SME and were related to the percentage decrease in NF-κB nuclear staining in nPQ cells. Similarly, TGF-ß (in the sinusoids) and MMP-9 (in nPQ) were increased in the STZ-SME group compared to the other groups; however, staining for CTGF, TIMP1, and Smad2/3 was lower. Conclusions: SME treatment in hyperglycemic rats induced by STZ may have hepatoprotective properties due to its scavenger capacity and the regulation of differential expression of antioxidant enzymes between the PQ and nPQ cells, reducing inflammatory and fibrogenic biomarkers in liver tissue.

Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome.

Nonalcoholic fatty liver disease (NAFLD) is considered a manifestation of metabolic syndrome (MS) and is characterized by the accumulation of triglycerides and a varying degree of hepatic injury, inflammation, and repair. Moreover, peroxisome-proliferator-activated receptors (PPARs) play a critical role in the pathophysiological processes in the liver. There is extensive evidence of the beneficial effect of polyphenols such as resveratrol (RSV) and quercetin (QRC) on the treatment of liver pathology; however, the mechanisms underlying their beneficial effects have not been fully elucidated. In this work, we show that the mechanisms underlying the beneficial effects of RSV and QRC against inflammation in liver damage in our MS model are due to the activation of novel pathways which have not been previously described such as the downregulation of the expression of toll-like receptor 4 (TLR4), neutrophil elastase (NE) and purinergic receptor P2Y2. This downregulation leads to a decrease in apoptosis and hepatic fibrosis with no changes in hepatocyte proliferation. In addition, PPAR alpha and gamma expression were altered in MS but their expression was not affected by the treatment with the natural compounds. The improvement of liver damage by the administration of polyphenols was reflected in the normalization of serum transaminase activities.

Cucurbita argyrosperma Seed Extracts Attenuate Angiogenesis in a Corneal Chemical Burn Model.

Severe corneal inflammation produces opacity or even perforation, scarring, and angiogenesis, resulting in blindness. In this study, we used the cornea to examine the effect of new anti-angiogenic chemopreventive agents. We researched the anti-angiogenic effect of two extracts, methanol (Met) and hexane (Hex), from the seed of Cucurbita argyrosperma, on inflamed corneas. The corneas of Wistar rats were alkali-injured and treated intragastrically for seven successive days. We evaluated: opacity score, corneal neovascularization (CNV) area, re-epithelialization percentage, and histological changes. Also, we assessed the inflammatory (cyclooxigenase-2, nuclear factor-kappaB, and interleukin-1ß) and angiogenic (vascular endothelial growth factor A, VEGF-A; -receptor 1, VEGFR1; and -receptor 2, VEGFR2) markers. Levels of Cox-2, Il-1ß, and Vegf-a mRNA were also determined. After treatment, we observed a reduction in corneal edema, with lower opacity scores and cell infiltration compared to untreated rats. Treatment also accelerated wound healing and decreased the CNV area. The staining of inflammatory and angiogenic factors was significantly decreased and related to a down-expression of Cox-2, Il-1ß, and Vegf. These results suggest that intake of C. argyrosperma seed has the potential to attenuate the angiogenesis secondary to inflammation in corneal chemical damage.

Evaluation of VEGF and PEDF in prostate cancer: A preliminary study in serum and biopsies.

Vascular endothelial growth factor (VEGF) and the pigment epithelium-derived factor (PEDF) serve an important role in prostate cancer (PCa). The aim of the present study was to evaluate whether the levels of VEGF and PEDF in serum are associated with the severity of PCa, and whether they can differentiate from patients with benign prostatic hyperplasia (BPH). Two groups of patients were recruited, patients with PCa or BPH that were newly diagnosed without other comorbidities, and were compared with healthy individuals. The levels of VEGF and PEDF were measured by ELISA in serum, and by immunohistochemistry in biopsies. A correlation analysis was performed for the values in biopsies and serum, comparing the VEGF/PEDF ratio, total-prostate-specific antigen (t-PSA) levels and the status of each sample as acinar Ad (Gleason score) or as benign hyperplasia. The results demonstrated that serum levels of VEGF, PEDF, and t-PSA between PCa and BPH were similar to each other, but different to healthy individuals (P<0.05). The VEGF/PEDF ratio in serum had a significant difference between acinar Ad with Gleason score 8-10 and BPH groups (P<0.05). The VEGF and PEDF immunostaining intensities were correlated with its circulating levels in all cases of PCa, but not in BPH. These preliminary results suggest that VEGF and PEDF levels by themselves or in combination with t-PSA did not differentiate between malignant, and benign prostate diseases. However, there was a significant difference observed in the VEGF/PEDF ratio in serum between the groups, suggesting that it may be used as an index for diagnosis and prognosis in a personalized manner, although more studies are necessary.

Air and fuel supercharge in the performance of a diesel cycle engine / Sobrealimentação de ar e combustível no desempenho de um motor ciclo Diesel

ABSTRACT: This paper aimed to evaluate the performance of a Diesel cycle engine, changing the configurations for the air and fuel supply system. Variables analyzed were torque, power, specific fuel consumption and thermal efficiency in four different engine configurations (aspirated, aspirated + service, turbocharged + service and turbocharged). For that, there were dynamometer experiments by power take-off of an agricultural tractor. The experimental outline used was entirely randomized, in a bifatorial design with three repetitions. Results indicated that the engine supercharge, compared to its original configuration, provided a significant increase of torque and power. Only the addition of turbo does not caused a significant effect in the engine performance. Application of turbocharger provides an improvement in the burning of the air/fuel mixture, which favors the increase of engine power and; consequently, reduced the specific fuel consumption.

RESUMO: Este trabalho teve como objetivo avaliar o desempenho de um motor ciclo Diesel, alterando a configuração do sistema de alimentação de ar e de combustível. As variáveis analisadas foram torque, potência, consumo específico de combustível e eficiência térmica em quatro diferentes configurações do motor (aspirado, aspirado + serviço, turboalimentado + serviço e turboalimentado). Para isso, foram realizados experimentos dinamométricos por meio da tomada de potência de um trator agrícola. O delineamento experimental utilizado foi inteiramente casualizado, em desenho bifatorial com três repetições. Os resultados indicam que, a sobrealimentação do motor, em relação à configuração original, proporciona aumento significativo do torque e potência. Somente a adição de turbo não causa efeito significativo no desempenho do motor. A aplicação do turbocompressor proporciona melhoria na queima da mistura ar/combustível, o que favorece o aumento da potência do motor e, consequentemente, reduz o consumo específico de combustível.

Mass of agricultural tractors available in the brazilian market / Massa dos tratores agrícolas comercializados no mercado brasileiro

ABSTRACT: Currently, manufacturers of agricultural tractors offer to farmers a diversity of brands, models, and settings for the most diverse agricultural operations. In this sense, the relation mass/power of tractor influences directly in the performance of these operations. The objective of this research was to study the agricultural wheel tractors marketed in Brazil in relation to their mass, in order to obtain current data to help their selection and proper use. The research involved 145 agricultural tractors models of eight different brands, including 2WD, MFWD and 4WD versions. The variables mass without ballast, relation mass/power for the different brands, type of traction and tractor power were analyzed separately. Tractor power was classified in: Class I (<50kW), Class II (50 to 150kW) and Class III (>150kW), according to the rated engine power declared by the manufacturer. Statistical analyses used were the t-Student and Tukey tests. The most number of tractors belongs to Class II and are considered versatile due to their mass/power relation, and can be used in the most diverse agricultural operations. From these analyses it was detected the mass/power relation decreases when the rated engine power increases.

RESUMO: Atualmente, os fabricantes de tratores agrícolas disponibilizam aos agricultores uma diversidade de marcas, modelos e configurações para as mais diversas operações agrícolas. Nesse sentido, a relação massa/potência do trator influencia de forma direta no desempenho dessas operações. Objetivou-se estudar os tratores agrícolas de rodas comercializados no mercado brasileiro, no que se refere a sua massa, visando obter dados atuais que auxiliem sua seleção e uso adequado. A pesquisa envolveu 145 modelos de tratores agrícolas de oito marcas diferentes, contemplando as versões 4x2, TDA e 4x4. Foram analisadas separadamente as variáveis massa sem lastro e relação massa/potência para as diferentes marcas, tipo de tração e potência do trator, sendo esta última classificada em: Classe I (menores que 50kW), Classe II (entre 50 e 150kW) e Classe III (maiores que 150kW), de acordo com a potência nominal do motor, declarada pelo fabricante. As análises estatísticas foram realizadas por meio dos testes t de Student e Tukey. O maior número de tratores pertence à Classe II, sendo considerados versáteis, devido à sua relação massa/potência, podendo ser usados nas mais diversas operações agrícolas. Há uma tendência de os tratores agrícolas comercializados no mercado brasileiro diminuírem sua relação massa/potência, conforme aumenta a potência nominal do motor.

Performance of an agricultural engine using blends of diesel and ethanol / Desempenho de um motor agrícola utilizando misturas de óleo diesel e etanol

ABSTRACT: This research evaluated the performance of a diesel engine in an agricultural tractor, using Diesel S500 (B5) and mixture with 3% (ED3), 6% (ED6), 9% (ED9), 12% (ED12) and 15% (ED15) of hydrous ethanol. Variables evaluated were the power, torque, specific fuel consumption, torque reserve, speed reserve and elasticity index of engine. Results indicated that using B5 and ED3 the values of torque and engine power not differ, in addition, with the ED3 the fuel consumption was lower than 5.92%. Using ED12, power has reduced in 2.97%, compared with B5, while their fuel consumption had no difference. With ED15, the power was lower 6.30% and the fuel consumption increase 3.77%, both compared with B5. Torque reserve value was increased with increasing the ethanol content in B5, reducing the speed reserve and elasticity index of engine. Ethanol in Diesel S500 (B5) can be used as an alternative fuel in agricultural tractor engines without presenting high changes in the performance, since the ethanol content is at low percentages, up to 12%.

RESUMO: Neste trabalho, foi avaliado o desempenho de um motor ciclo Diesel de um trator agrícola, utilizando óleo Diesel S500 (B5) e sua mistura com 3% (ED3), 6% (ED6), 9% (ED9), 12% (ED12) e 15% (ED15) de etanol hidratado. As variáveis estudadas foram: potência, torque, consumo específico de combustível, reserva de torque, reserva de rotação e índice de elasticidade do motor. Os resultados indicam que, utilizando B5 e ED3, os valores de torque e potência do motor não diferiram, além disso, com o ED3, o consumo de combustível foi 5,92% menor. Utilizando ED12, a potência, em relação ao B5, teve uma redução de 2,97%, sem diferença para o consumo de combustível. Já com o ED15, a potência diminuiu 6,30% e o consumo aumentou 3,77%, em comparação com o B5. Os valores de reserva de torque foram incrementados conforme aumentou o conteúdo de etanol, reduzindo a reserva de rotação e o índice de elasticidade do motor. A mistura de etanol no óleo Diesel B5 pode ser utilizada como combustível alternativo em motores agrícolas, sem apresentar alterações significativas no seu desempenho, desde que seja utilizado até 12% de etanol.

Temozolomide for aggressive ACTH pituitary tumors: failure of a second course of treatment.

INTRODUCTION: Temozolomide (TMZ) is an oral alkylating agent that has been used over the past 8 years to treat aggressive pituitary tumors resistant to conventional therapy. To date, only 25 patients treated with TMZ for ACTH producing pituitary tumors (14 adenomas and 11 carcinomas) have been reported. MATERIALS AND METHODS: We present a retrospective review of the medical records of three patients with aggressive ACTH producing adenomas treated with TMZ. In the three cases there was evidence of progression to conventional therapy before starting TMZ. We used the conventional scheme for the treatment of gliomas until completing 7, 12 and 6 cycles respectively. Reduction in tumor size was evident after the 3rd, 5th and 4th cycle of TMZ and progression free survival was 25, 19 and more than 12 months in the three patients respectively. Improvement of the ocular and visual symptoms was evident after the 4th cycle of treatment in all cases. Normalization of urinary free cortisol levels was achieved after the 3rd and 9th cycle in the two cases with hypercortisolism. Two of the three patients received a second course of treatment when the disease progressed but it did not stop tumor progression. The principal side effects were G3 neutropenia, G1 and G2 thrombocytopenia, G1 lymphopenia, asthenia and nausea. CONCLUSION: The treatment with TMZ is effective and safe in patients with aggressive corticotrophin tumors resistant to conventional therapy. Nevertheless once the disease progresses, a second course of treatment does not seem to be effective.

Critérios técnicos para a seleção de pulverizadores autopropelidos comercializados no mercado brasileiro / Technical criteria for the selection of self-propelled sprayers available in the Brazilian market

Nos últimos anos, a oferta de pulverizadores autopropelidos no mercado brasileiro aumentou, principalmente para suprir a demanda de agricultores que possuem grandes extensões de áreas, nas quais se requer um alto ritmo operacional. Neste trabalho, foram avaliados, em função da potência nominal do motor, os diferentes tipos de transmissões, a capacidade do reservatório de calda, tamanho das barras e vão livre, considerados critérios técnicos importantes para a seleção dessas máquinas. Para tanto, utilizaram-se informações técnicas de 41 modelos de pulverizadores autopropelidos comercializados no mercado brasileiro. Como resultado, classificaram-se os pulverizadores em cinco classes, segundo a potência do motor. Verificou-se que, com o aumento da potência, os pulverizadores são equipados com transmissão hidrostática e a capacidade dos reservatórios de calda são maiores.

In recent years the offer of self-propelled sprayers in the Brazilian market increased mainly to supply the demand of farmers who own large areas where there are a high operational pace requirement. In this research the different kinds of transmissions, tank capacity of spray mix, width of bars and clearance, which are considered important technical criteria, were evaluated according to nominal engine power. Technical information of 41 self-propelled sprayer models commercialized in Brazilian market were used. As result, sprayers were classified in five classes, according to the engine power. It was verified that, with the increase of power, the sprayers are equipped with hydrostatic transmission and the tank capacity of spray mix are higher.

Neurocognitive long-term impact of two-field conventional radiotherapy in adult patients with operated pituitary adenomas.

PURPOSE: To assess the long-term impact of postoperative two-field-conventional radiotherapy (RT) on neurocognitive functions of adult patients with operated pituitary adenomas (PA). METHODS: We selected 124 adult patients with operated PA-56 of whom had also received RT-recorded their main clinical data and performed a neuropsychological assessment in all of them that included 15 standardized tests, and a cerebral SPECT in eight patients. Comparative analyses were carried out on major clinical and neurocognitive domains between irradiated and not irradiated patients, and on cerebral SPECT source. RESULTS: Compared with non-irradiated patients, irradiated patients performed significantly worse on Barcelona's story recall test (P < 0.001) and arithmetic problems (P < 0.03) and on five categories of the Wisconsin card sorting test, especially on perseverative answers and errors (P < 0.001) without differences in other examined functional domains. RT was the only factor associated with worse results in these tests regardless other clinical and treatment-related variables. Kaplan-Meier analysis suggested that the probability of achieving poorer results with time was related to RT total dose and field-size, type of PA and age at the time of RT. Four of the five SPECTS performed in irradiated patients revealed a similar altered perfusion in the left temporal lobe cortical region. CONCLUSIONS: In adult patients with operated PA, RT was independently associated with an impairment on verbal memory and executive function, when compared to non-irradiated patients. Our data suggest that diagnosis of acromegaly or Cushing's disease, and age at the time of RT were able to modulate this long-term radio-induced neurocognitive sequelae.

Electrical Stimulation at the ST36 Acupoint Protects against Sepsis Lethality and Reduces Serum TNF Levels through Vagus Nerve- and Catecholamine-Dependent Mechanisms.

Electrical vagus nerve (VN) stimulation during sepsis attenuates tumor necrosis factor (TNF) production through the cholinergic anti-inflammatory pathway, which depends on the integrity of the VN and catecholamine production. To characterize the effect of electroacupuncture at ST36 (EA-ST36) on serum TNF, IL-6, nitrite, and HMGB1 levels and survival rates, based on VN integrity and catecholamine production, a sepsis model was induced in rats using cecal ligation and puncture (CLP). The septic rats were subsequently treated with EA-ST36 (CLP+ST36), and serum samples were collected and analyzed for cytokines levels. The serum TNF, IL-6, nitrite, and HMGB1 levels in the CLP+ST36 group were significantly lower compared with the group without treatment, the survival rates were significantly higher (P < 0.05), and the acute organ injury induced by CLP was mitigated by EA-ST36; however, when subdiaphragmatic vagotomy was performed, the serum levels of TNF in the CLP+ST36 group did not show a significant difference compared with the group without electrostimulation, and, similarly, no significant difference in serum TNF levels was found under the pharmacological blockade of catecholamines. These results suggest that in rats with CLP sepsis models EA-ST36 reduces serum TNF levels through VN- and atecholamine-dependent mechanisms.

Results of repeated transsphenoidal surgery in Cushing's disease. Long-term follow-up.

OBJECTIVE: Transsphenoidal surgery (TSS) is the treatment of choice for Cushing's disease (CD). However, the best treatment option when hypercortisolism persists or recurs remains unknown. The aim of this study was to analyze the short and long-term outcome of repeat TSS in this situation and to search for response predictors. PATIENTS AND METHODS: Data from 26 patients with persistent (n=11) or recurrent (n=15) hypercortisolism who underwent repeat surgery by a single neurosurgeon between 1982 and 2009 were retrospectively analyzed. Remission was defined as normalization of urinary free cortisol (UFC) levels, and recurrence as presence of elevated UFC levels after having achieved remission. The following potential outcome predictors were analyzed: adrenal status (persistence or recurrence) after initial TSS, tumor identification in imaging tests, degree of hypercortisolism before repeat TSS, same/different surgeon in both TSS, and time to repeat surgery. RESULTS: Immediate postoperative remission was achieved in 12 patients (46.2%). Five of the 10 patients with available follow-up data relapsed after surgery (median time to recurrence, 13 months). New hormone deficiencies were seen in seven patients (37%), and two patients had cerebrospinal fluid leakage. No other major complications occurred. None of the preoperative factors analyzed was predictive of surgical outcome. CONCLUSIONS: When compared to initial surgery, repeat TSS for CD is associated to a lower remission rate and a higher risk of recurrence and complications. Further studies are needed to define outcome predictors.

Detección de una mutación en el gen KCNQ1 (KvLQT1) causante de síndrome de Jervell, Lange-Nielsen en una familia mexicana / KCNQ 1 (KvLQT1) missense mutation causing congenital long QT syndrome (Jervell-Lange-Nielsen) in a Mexican family

BACKGROUND: Long QT syndromes (LQTS) are inherited cardiac disorders caused by mutations in the genes that encode sodium or potassium transmembrane ion channel proteins. More than 200 mutations, in at least six genes, have been found in these patients. The Jervell and Lange-Nielsen (JLN) syndrome is the recessive form of the disease and is associated with deafness. Few families with JLN syndrome and genetic studies are reported in the literature. METHODS: The KCNQ1 (KvLQT1) gene in a Mexican family with Jervell-Lange-Nielsen long QT syndrome was analyzed using an automated sequence method. RESULTS: A missense mutation was found in the three affected individuals. This mutation is associated with complete loss of channel function. Correlation with the phenotype showed a prolonged QTc interval and deafness in the two siblings homozygous to the mutation. The mother, who was heterozygous for the mutation, also had prolonged QTc interval without deafness. The father and younger brother had normal QTc intervals. The mutation was not found in 50 healthy controls studied. CONCLUSIONS: We describe for the first time a mutation in the KCNQ1 gene in a Mexican family with JLN long QT syndrome. This mutation produces an amino acid change (Gly-Arg) at protein level at the 168 residue. This mutation has been previously reported in Caucasian families with LQTS.

Malignant prolactinoma with multiple bone and pulmonary metastases. Case report.

Malignant prolactinomas, as with other pituitary carcinomas, are rare tumors. The authors describe a 14-year-old boy who presented with visual loss caused by a pituitary prolactinoma. He underwent transsphenoidal surgery, radiotherapy, and dopamine agonist therapy, but 6 years after the initial diagnosis his pituitary tumor regrew and bone and pulmonary metastases developed. The authors review the literature and discuss the clinical presentation of malignant prolactinomas, their rarity, histological characteristics, distribution of the metastases, different treatment approaches, and their poor prognosis.

Is unilateral adrenalectomy an alternative treatment for ACTH-independent macronodular adrenal hyperplasia?: Long-term follow-up of four cases.

OBJECTIVE: ACTH-independent macronodular adrenal hyperplasia is a rare cause of Cushing's syndrome. Bilateral adrenalectomy is considered the treatment of choice, but the patient is obliged to receive lifetime steroid replacement therapy and is susceptible to adrenal insufficiency crisis. New therapeutic alternatives are being proposed as new etiopathological features of the disease are known. Unilateral adrenalectomy of the largest gland can be a safe and effective alternative, but only short-term follow-up is reported in the literature. We present four consecutive patients with ACTH-independent macronodular hyperplasia and long-term remission of Cushing's syndrome after unilateral adrenalectomy. SUBJECTS: Four consecutive patients (two males and two females, mean age 50.3 years) with Cushing's syndrome due to ACTH-independent macronodular adrenal hyperplasia underwent unilateral adrenalectomy of the largest gland. RESULTS: The weight of the resected glands ranged from 26.8 to 210 g. Two patients suffered transient post-surgical adrenal insufficiency and had steroid replacement therapy for 60 and 14 months respectively. After a mean follow-up of 78.8 months (range 30-137 months) all the patients persist without any evidence of Cushing's syndrome. Urinary free cortisol and serum cortisol, after the adrenal insufficiency stage, have always stayed within their normal ranges, but cortisol circadian rhythm and suppressibility after dexamethasone have never normalized. No further enlargement of the contralateral gland has been documented 62 to 126 months after surgery in three of the four patients. CONCLUSIONS: Unilateral adrenalectomy can be an effective and safe alternative treatment for ACTH-independent macronodular adrenal hyperplasia, and can achieve long-term remission of Cushing's syndrome.

Tratamiento de piodermitis recurrente con ofloxacin. Centro de especialistas CES Sabaneta. 1988–1989 / Recurrent piodermitis treatment with ofloxacin. Specialists Center CES. Sabaneta, 1988 – 1989

Se realizó un estudio observacional, descriptivo, en la consulta externa de dermatología del Centro de Especialistas CES de Sabaneta (Ant.) entre Agosto de 1988 y Agosto de 1989. Se trataron veintiocho pacientes con Piodermitis recurrente con ofloxacín, una quinolona de amplio espectro, que ha demostrado gran actividad bactericida in vitro. Cada uno de los pacientes que ingresó al estudio tenía historia documentada de enfermedad infecciosa recurrente de la piel, que no había cedido a los antiblóticos usados comúnmente como terapia en estas enfermedades. Se les realizaron pruebas clínicas y de laboratorio antes del Ingreso al estudio, a los siete días de tratamiento y al mes de terminada la terapia, la cual consistía en 200 mg de ofloxacin cada 12 horas por 7 días. El tratamiento en estas condiciones demostró ser 100 por ciento eficaz para la foliculitis, 50 por ciento para la forunculosis y 0 por ciento para la hidradenitis supurativa...