RESUMO
OBJECTIVE: In an effort to evaluate the prognosis of threatened abortion, we established the ratio of serum human chorionic gonadotropin (hCG), as measured by bioassay or radioimmunoassay techniques, of samples from patients with threatened abortion or normal pregnancy. STUDY DESIGN: Peripheral blood samples from patients in their first trimester of pregnancy with threatened abortion (n=24), or normal pregnancy (n=12), were assayed for progesterone (RIA), and for immunoactive (DELFIA) and bioactive (mouse Leydig cell testosterone production assay) hCG. RESULTS: Serum progesterone was not statistically different between the threatened-continuing and the threatened-miscarried groups. The ratio of hCG bioactive/hCG immunoactive (B/I) was significantly lower for the patients of the threatened group that experienced abortion. The B/I ratio for the control and threatened-continuing patients was similar. CONCLUSION: The hCG bioactive/hCG immunoactive ratio could be a good indicator of the prognosis of threatened abortion.
Assuntos
Ameaça de Aborto/diagnóstico , Gonadotropina Coriônica/sangue , Progesterona/sangue , Ameaça de Aborto/sangue , Ameaça de Aborto/imunologia , Adulto , Biomarcadores/sangue , Gonadotropina Coriônica/imunologia , Feminino , Humanos , Gravidez , Resultado da Gravidez , Primeiro Trimestre da Gravidez/sangue , PrognósticoRESUMO
Presentamos el caso de una paciente con un diagnóstico de hipotiroidismo primario, la cual fue tratada en forma irregular previo a su ingreso en la maternidad. Se pudo comprobar una vez más que, a pesar de esta anormalidad, la función reproductora materna no fue afectada, obteniéndose un R.N. normal con integridad en su función tiroidea