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Bull Exp Biol Med ; 176(4): 461-465, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38491257

RESUMO

Type 2 diabetes mellitus develops due to a combination of genetic and environmental factors. C57BL/6 mice prone to obesity and leptin resistance were kept on a high-fat diet for 21 weeks. The animals showed a significant increase in fasting and postprandial glucose levels and body weight, the development of insulin resistance, and by week 18, an increase in the serum TNFα level. Metformin therapy at a dose of 250 mg/kg was effective against the background of disturbances in carbohydrate metabolism: animals showed a significant decrease in insulin resistance and TNFα level.


Assuntos
Diabetes Mellitus Tipo 2 , Resistência à Insulina , Camundongos , Animais , Diabetes Mellitus Tipo 2/genética , Dieta Hiperlipídica/efeitos adversos , Insulina , Fator de Necrose Tumoral alfa/genética , Glicemia , Camundongos Endogâmicos C57BL , Fatores de Risco
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