Reaction of bone marrow hematopoiesis to the toxic effect of paclitaxel.

Intraperitoneal injection of paclitaxel (Mitotax) in a single dose of 40 mg/kg was followed by an increase in the number of mitotic granulocytic and erythroid cells, hypoplasia, and pancytopenia of the bone marrow in CBA/CaLac mice. The test preparation decreased the number of hematopoietic precursor cells for erythropoiesis and granulocytopoiesis, but increased the count of polyploid cells and incidence of structural and genomic abnormalities in bone marrow cells. These changes were reversible.

[LH, FSH and progesterone level in the blood plasma of women with normal menstrual cycle]. / Uroven' liuteiniziruiushchego, follikulostimuliruiushchego gormonov i progesterona v plazme krovi u zhenshchin s normal'nym menstrual'nym tsiklom

Luteinizing hormone (LH), folliculostimulating hormone (FSH) and progesterone were studied by the radioimmunoassay in a group of 10 women throughout a normal menstrual cycle. The LH and the FSH peak occurs at the middle of the cycle. At the early follicular phase the FSH level was higher than that of the LH. During the follicular and the lutein phases the plasma progesterone level was 0.65 +/- 0.12 ng/ml and 12.4 +/- 2.3 ng/ml, respectively. The laboratory criteria of the normal ovular cycle are: a) a mid-cycle LH peak; b) plasma progesterone level at the lutein phase were 10-15 times greater than at the follicular one; c) progesterone peak at the mid-lutein phase; d) the duration of the lutein phase of 12-15 days.