Oral amyloidosis: an update.

BACKGROUND: Amyloidosis is a disease characterized by the progressive deposition of abnormal proteins that can occur in any organ. In the oral cavity, the tongue is the most common affected site, usually causing macroglossia. Biopsy is essential for the diagnosis and the occurrence of its systemic form is mandatory to be investigated. This systematic review evaluated the existing information in the literature on Amyloidosis in the oral cavity to allow a more comprehensive and updated analysis of its clinicopathological characteristics, as well as to explore the main forms of treatment and prognostic factors. MATERIAL AND METHODS: Electronic searches were undertaken in five databases supplemented by manual scrutiny. RESULTS: A total of 111 studies were included with 158 individuals. CONCLUSIONS: The disease had a higher prevalence in women, the tongue was the most affected site, as well as the systemic form of the disease. The worst prognosis was for cases of systemic amyloidosis associated with multiple myeloma.

Tendências genética e fenotípica para ganho de peso médio diário entre a desmama e o sobreano em uma população Angus x Nelore / Genetic and phenotypic trends for average daily weight gain from weaning to 550 days of age in a Angus Nellore population

Foram analisados os registros de ganho médio diário entre a desmama e o sobreano (GMDDS) de 33.267 animais de uma população multirracial Angus - Nelore, filhos de 525 touros, criados em 37 rebanhos, em diversas regiões do Brasil, entre os anos de 1987 e 2001. O modelo animal usado incluiu os efeitos aleatórios genético aditivo direto e materno e residual e os efeitos fixos de grupo genético do pai, da mãe e do animal e do grupo de contemporâneos pós-desmama, além da covariável idade à desmama, não ajustada. O GMDDS médio observado para a população foi 384,22g. O ano de 1999 foi o que apresentou o maior GMDDS (484,04g), e o ano de 1992, o menor (299,42g). Os coeficientes de herdabilidade estimados foram: 0,30±0,11 (direta) e 0,29±0,07 (materna). O VG médio foi de -0,827g. A tendência genética estimada para essa característica foi de -0,029g/ano (P<0,08) e a fenotípica foi de 5,69g/ano (P<0,05).

Direct and maternal heritability coefficients were estimated and genetic and phenotypic trends were predicted for average weight gain from weaning to 550 days of age (AWG) from 33,267 animals of a multi-breed Angus-Nellore population, sired by 525 bulls and raised in 37 herds in several regions of Brazil, from 1987 to 2001. MTDFREML was used for estimating the (co)variance components utilized to estimate the genetic direct and maternal heritability coefficients and to predict the breeding values. The animal model included as fixed the genetic group of sire, dam and animal and the pos weaning year/station/herd contemporary group and the covariate weaning age, and as ramdom, the additive genetic, maternal and residual effects. The observed AWG was 384.22g, 1999 presented the highest (484.04g) and 1992 the lowest value (299.42g). The direct heritability was 0.30±0.11, the maternal h² was 0.29±0.07 and the average genetic value was -0.827g. The estimated genetic trend for AWG was -0.029g (P<0.08) and the phenotypic trend was 5.68g (P<0.05). A phenotypic progress for average weight gain from weaning to 550 days of age occurred as a consequence of an environmental improvement, and the estimated genetic progress was close to zero.

Diabetes mellitus: new therapeutic approaches to treat an old disease

Diabetes mellitus is a widespread disease whose frequency increases constantly and is expected to reach alarming levels by the year 2025. Introduction of insulin therapy represented a major breakthrough; however, a very strict regimen is required to maintain blood glucose levels within the normal range and to prevent or postpone chronic complications associated with this disease. Frequent hyper- and hypoglycemia seriously affect the quality of life of these patients. Reversion of this situation can only be achieved through whole organ (pancreas) transplant or pancreatic islet transplant, the former being a high-risk surgical procedure, while the latter is a much simpler and may be accomplished in only 20-40 min. The advantages and perspectives of islet cell transplantation will be discussed, in the light of tissue engineering and gene therapy. Ongoing research carried out in our laboratory, aimed at developing clinical cell and molecular therapy protocols for diabetes will also be focused