Cáncer gástrico en una zona con alto potencial para la cultura apícola y su aplicación en la prevención de las lesiones gástricas premalignas y malignas / Gastric cancer in an area of high potential for beekiping culture and its application in the prevention of premalignat and malignat gastric lesion

El cáncer gástrico es la principal causa de muerte por cáncer del estado Táchira - Venezuela. Con una particular elevada tasa de mortalidad en los estados andinos. Los esfuerzos realizados en la detección temprana basados en estudios radiológicos y endoscópicos no han permitido cubrir gran parte de la población. La identificación de lesiones pre malignas y cáncer asociadas a la infección por Helicobacter pylori han obligado al desarrollo de proyectos epidemiológicos de prevención primaria que tiendan a incidir sobre estilos de vida y factores dietéticos. La erradicación de H. pylori con el uso de terapia antimicrobiana convencional ha dado resultados controvertidos en diferentes latitudes, con los mismos esquemas terapéuticos. La capacidad antimicrobiana de diferentes tipos de propóleos ante el H. pylori, ya ha sido evaluada, siendo el principal responsable los flavonoides: pinocembrina, galangina y crisina. La alta prevalencia de H. pylori en la Aldea Potrero de las Casas, Táchira, Venezuela, aunado al potencial y cultura apícola de la zona promueven estudios de intervención con productos de la colmena que son accesibles y de bajo costo

Gastric Cancer is the leading cause of cancer death in Táchira State - Venezuela with a high mortality rate especially in the Andean States. Efforts at early gastric cancer detection based on radiological and endoscopic studies have failed to cover all the population. The identification of premalignant gastric lesion and gastric cancer associated with Helicobacter Pylori infection have led to the development of epidemiological primary prevention projects that led to influence on dietary and life style factors Helicobacter Pylori eradication using conventional therapy has been controversial results in differents latitudes with the same therapeutics regimens. The antimicrobial activity of different types of propolis against Helicobacter Pylori has been evaluated, the main responsibility are flavonoids,pinocembrin, galactin and chrysin. The high prevalence of Helicobacter Pylori in the village of Potrero de las Casas, Táchira Venezuela together with the potential of the area in the bee culture induce to think about to promote intervention studies with bee products that are accessible and low cost

Antioxidant activity of uruguayan propolis. In vitro and cellular assays.

The antioxidant capacity of propolis from the southern region of Uruguay was evaluated using in vitro as well as cellular assays. Free radical scavenging capacity was assessed by ORAC, obtaining values significantly higher than those of other natural products (8000 µmol Trolox equiv/g propolis). ORAC values correlated well with total polyphenol content (determined by Folin-Ciocalteu method) and UV absorption. Total polyphenol content (150 mg gallic acid equiv/g propolis) and flavonoids (45 mg quercetin equiv/g propolis) were similar to values reported for southern Brazilian (group 3) and Argentinean propolis. Flavonoid composition determined by RP-HPLC indicates a strong poplar-tree origin. Samples high in polyphenols efficiently inhibit low-density lipoprotein lipoperoxidation and tyrosine nitration. In addition, Uruguayan propolis was found to induce the expression of endothelial nitric oxide synthase and inhibit endothelial NADPH oxidase, suggesting a potential cardiovascular benefit by increasing nitric oxide bioavailability in the endothelium.