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1.
Andrology ; 7(6): 818-826, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31115178

RESUMO

BACKGROUND: Sperm counts have been steadily decreasing over the past five decades with regional differences in the Western world. The reasons behind these trends are complex, but numerous insights indicate that environmental and lifestyle factors are important players. OBJECTIVE: To evaluate semen quality and male reproductive health in Switzerland. MATERIALS AND METHODS: A nationwide cross-sectional study was conducted on 2523 young men coming from all regions of Switzerland, recruited during military conscription. Semen volume, sperm concentration, motility, and morphology were analyzed. Anatomy of the genital area and testicular volume was recorded. Testicular cancer incidence rates in the general population were retrieved from Swiss regional registries. RESULTS: Median sperm concentration adjusted for period of sexual abstinence was 48 million/mL. Comparing with the 5th percentile of the WHO reference values for fertile men, 17% of men had sperm concentration below 15 million/mL, 25% had less than 40% motile spermatozoa, and 43% had less than 4% normal forms. Disparities in semen quality among geographic regions, urbanization rates, and linguistic areas were limited. A larger proportion of men with poor semen quality had been exposed in utero to maternal smoking. Furthermore, testicular cancer incidence rates in the Swiss general population increased significantly between 1980 and 2014. DISCUSSION: For the first time, a systematic sampling among young men has confirmed that semen quality is affected on a national level. The median sperm concentration measured is among the lowest observed in Europe. No specific geographical differences could be identified. Further studies are needed to determine to what extent the fertility of Swiss men is compromised and to evaluate the impact of environmental and lifestyle factors. CONCLUSION: A significant proportion of Swiss young men display suboptimal semen quality with only 38% having sperm concentration, motility, and morphology values that met WHO semen reference criteria.


Assuntos
Oligospermia/epidemiologia , Análise do Sêmen , Motilidade dos Espermatozoides/fisiologia , Espermatozoides/fisiologia , Adolescente , Estudos Transversais , Feminino , Humanos , Estilo de Vida , Masculino , Exposição Materna/efeitos adversos , Contagem de Espermatozoides , Suíça/epidemiologia , Adulto Jovem
2.
Mycoses ; 34(3-4): 153-65, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-1749395

RESUMO

The pattern of invasion of human hair in vitro by a non-dermatophytic fungus, Chrysosporium tropicum, was studied by transmission and scanning electron microscopy. The components of the hair were attacked in sequence, depending on their level of keratinization, i.e. their content of cystine. In the cuticle, the sequence of digestion was as follows: intercellular material, cytoplasmic membrane, endocuticle, exocuticle, layer A, and a thinner layer below the inner cytoplasmic membrane of the cuticle cells. In the cortex, the order was: cementing material, plasmalemma, intermacrofibrillar material, microfibrils and matrix of the microfibrils. At the same time a different mode of attack was radial penetration of the various layers without regard to degree of keratinization. This occurred by means of perforating hyphae originating in the cuticle from structures similar to appressoria. With both modes of attack, the process showed all the characteristics of enzymatic digestion rather than physical breakdown. Ch. tropicum thus demonstrated important physiological parallels with dermatophytes in its demolition of hair in vitro. This could be of interest in predicting its ability to infect in vivo.


Assuntos
Chrysosporium/crescimento & desenvolvimento , Cabelo/microbiologia , Chrysosporium/ultraestrutura , Cabelo/ultraestrutura , Humanos , Microscopia Eletrônica , Microscopia Eletrônica de Varredura
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