Acute pesticide poisoning: Comparison of epidemiological characteristics between the rural and urban population

Objective: To analyze the behavior of pesticide poisoning associated with lethality in rural and urban populations in Colombia from 2007 to 2017. Methodology: Retrospective observational study that included a descriptive cross-sectional study and an ecological design that analyzed aggregate measures of morbidity, mortality, and risk attributable to the population in rural and urban areas. In the cross-sectional study, the relative risk was estimated to measure the factors associated with lethality among intoxications using Poisson regression with logarithmic function. For the time series, the trends were established with simple linear regression, and the seasonal decomposition was performed using the multiplicative model. Autocorrelations were tested using the Box-Ljung statistic. Results: Between 2007-2017; 89 490 cases were reported. The Morbidity due to poisoning showed a higher proportion in the rural population 36.03 cases per 100 000; this indicator was three times higher than in urban areas (12.33 cases per 100 000). The mortality rates in rural and urban areas were 1.00 and 0.13 cases per 100 000, respectively. The relative risk of fatality in case of intoxication was associated with the intention of suicide in the rural population Relative Risk (RR): 5.9 (95% CI: 5.0-6.9). Conclusion: A higher proportion of lethality associated with these events occurred in populations living in rural areas and reporting cases of suicidal intent. In addition, morbidity and mortality due to pesticide poisoning had the highest proportion in rural areas and a growing trend over time.

Objetivo: Analizar el comportamiento de las intoxicaciones por plaguicidas en poblaciones rurales y urbanas asociadas a la letalidad en Colombia durante 2007-2017. Metodología: Estudio observacional retrospectivo que incluyó: un estudio descriptivo transversal y un diseño ecológico que analizó medidas agregadas de morbilidad, mortalidad y riesgo atribuibles a la población en áreas rurales y urbanas. En el estudio transversal se estimó el riesgo relativo para medir los factores asociados a la letalidad entre las intoxicaciones mediante regresión de Poisson con función logarítmica. Para la serie de tiempo, las tendencias se establecieron con regresión lineal simple y la descomposición estacional se realizó mediante el modelo multiplicativo. Las autocorrelaciones se probaron mediante el estadístico Box-Ljung. Resultados: Entre 2007-2017; Se notificaron 89 490 casos. La Morbilidad por intoxicación presentó mayor proporción en la población rural 36,03 casos por 100 000; este indicador fue tres veces mayor que en las áreas urbanas (12,33 casos por 100 000). Las tasas de mortalidad en el área rural y urbana fueron de 1,00 y 0,13 casos por 100 000, respectivamente. El riesgo relativo de fatalidad en caso de intoxicación se asoció con la intención de suicidio en la población rural RR: 5,9 (IC 95%: 5,0-6,9). Conclusión: Una mayor proporción de letalidad asociada a estos eventos ocurrió en poblaciones que viven en áreas rurales y reportan casos de intención suicida. Además, la morbilidad y mortalidad por intoxicación por plaguicidas tuvo la mayor proporción en las zonas rurales y una tendencia creciente en el tiempo.

Objetivo: Analisar o comportamento das intoxicações por agrotóxicos em populações rurais e urbanas associadas à letalidade na Colômbia durante 2007-2017. Metodologia: Estudo observacional retrospectivo que incluiu: estudo transversal descritivo e delineamento ecológico que analisou medidas agregadas de morbidade, mortalidade e risco atribuíveis à população em áreas rurais e urbanas. No estudo transversal, o risco relativo foi estimado para medir os fatores associados à letalidade entre as intoxicações por meio da regressão de Poisson com função logarítmica. Para as séries temporais, as tendências foram estabelecidas com regressão linear simples e a decomposição sazonal foi realizada usando o modelo multiplicativo. As autocorrelações foram testadas usando a estatística Box-Ljung. Resultados: Entre 2007-2017; 89.490 casos foram notificados. A Morbidade por intoxicação apresentou maior proporção na população rural 36,03 casos por 100.000; este indicador foi três vezes superior ao das zonas urbanas (12,33 casos por 100 000). As taxas de mortalidade nas áreas rural e urbana foram de 1,00 e 0,13 casos por 100.000 habitantes, respectivamente. O risco relativo de fatalidade em caso de intoxicação associou-se à intenção de suicídio na população rural RR: 5,9 (IC 95%: 5,0-6,9). Conclusão: Maior proporção de letalidade associada a esses eventos ocorreu em populações residentes em áreas rurais e com relato de casos de intenção suicida. Além disso, a morbimortalidade por intoxicação por agrotóxicos teve maior proporção na zona rural e tendência crescente ao longo do tempo.

ZnO-Loaded Graphene for NO2 Gas Sensing.

This paper investigates the effect of decorating graphene with zinc oxide (ZnO) nanoparticles (NPs) for the detection of NO2. In this regard, two graphene sensors with different ZnO loadings of 5 wt.% and 20 wt.% were prepared, and their responses towards NO2 at room temperature and different conditions were compared. The experimental results demonstrate that the graphene loaded with 5 wt.% ZnO NPs (G95/5) shows better performance at detecting low concentrations of the target gas than the one loaded with 20 wt.% ZnO NPs (G80/20). Moreover, measurements under dry and humid conditions of the G95/5 sensor revealed that the material is very sensitive to ambient moisture, showing an almost eight-fold increase in NO2 sensitivity when the background changes from dry to 70% relative humidity. Regarding sensor selectivity, it presents a significant selectivity towards NO2 compared to other gas compounds.

Toxicology assessment of manganese oxide nanomaterials with enhanced electrochemical properties using human in vitro models representing different exposure routes.

In the present study, a comparative human toxicity assessment between newly developed Mn3O4 nanoparticles with enhanced electrochemical properties (GNA35) and their precursor material (Mn3O4) was performed, employing different in vitro cellular models representing main exposure routes (inhalation, intestinal and dermal contact), namely the human alveolar carcinoma epithelial cell line (A549), the human colorectal adenocarcinoma cell line (HT29), and the reconstructed 3D human epidermal model EpiDerm. The obtained results showed that Mn3O4 and GNA35 harbour similar morphological characteristics, whereas differences were observed in relation to their surface area and electrochemical properties. In regard to their toxicological properties, both nanomaterials induced ROS in the A549 and HT29 cell lines, while cell viability reduction was only observed in the A549 cells. Concerning their skin irritation potential, the studied nanomaterials did not cause a reduction of the skin tissue viability in the test conditions nor interleukin 1 alpha (IL- 1 α) release. Therefore, they can be considered as not irritant nanomaterials according to EU and Globally Harmonized System of Classification and Labelling Chemicals. Our findings provide new insights about the potential harmful effects of Mn3O4 nanomaterials with different properties, demonstrating that the hazard assessment using different human in vitro models is a critical aspect to increase the knowledge on their potential impact upon different exposure routes.

Riesgo suicida y estrategias de afrontamiento al estrés en población campesina colombiana / Suicidal risk and strategies for coping with stress in Colombian rural population

Resumen Introducción: El comportamiento suicida hace referencia a las diversas conductas para dejar de vivir es un fenómeno multifactorial ampliamente estudiado en población urbana, sin embargo, la población campesina, especialmente agricultores y trabajadores agrícolas están entre los grupos de alto riesgo. Objetivo: Evaluar las relaciones entre el riesgo suicida y las estrategias de afrontamiento al estrés en una muestra de 76 campesinos entre los 18 y 79 años del municipio de El Santuario, Colombia, durante la emergencia sanitaria por Covid-19. Método: Para este estudio se utilizó un diseño descriptivo correlacional de corte transversal y se emplearon como instrumentos la Escala de Evaluación de Riesgo Suicida -ERS- y la Escala de Estilos y Estrategias de Afrontamiento (EEEAE). Resultados: Los resultados encontrados en la Escala ERS no indicaron niveles clínicos de riesgo suicida. Y respecto a la EEEAE casi siempre los participantes usaban las estrategias de Reevaluación positiva, Apoyo social, Desconexión cognitiva y Resolver el problema. Hubo correlaciones negativas entre todas las dimensiones de la escala ERS con EEEAE, menos entre las dimensiones Depresión/Desesperanza y Aislamiento/Soporte social (ERS) con la Desconexión cognitiva (EEEAE) y especialmente la estrategia de Reevaluación Positiva tuvo un peso significativo sobre riesgo suicida. Conclusiones: La Reevaluación Positiva es una estrategia de afrontamiento que puede proteger la salud mental ante situaciones de estrés asociados con el riesgo suicida de la población campesina, los agricultores y trabajadores agrícolas.

Abstract Introduction: Suicidal behavior refers to the various behaviors to stop living, it is a multifactorial phenomenon widely studied in the urban population, however, the rural population, especially farmers and agricultural workers, are among the high-risk groups. Objective: Evaluate the relationships between suicidal risk and stress coping strategies in a sample of 76 peasants between 18 and 79 years of age from the municipality of El Santuario, Colombia during the Covid-19 health emergency. Method: For this study, a cross-sectional correlational descriptive design was used. The Suicide Risk Assessment Scale -SRAS- and the Coping Styles and Strategies Scale were used as measurement instruments (CSSS). Results: The results found in the SRAS Scale did not indicate clinical levels of suicidal risk. And regarding the EEEAE, the participants almost always used the strategies of Positive Reappraisal, Social Support, Cognitive Disconnection and Problem-Solving skills. There were negative correlations between all the dimensions of the SRAS scale with CSSS, less between the dimensions Depression/Hopelessness and Isolation/social support (SRAS) with Cognitive Disconnection (CSSS) and especially the Positive Reappraisal had a significant weight on suicidal risk. Conclusions: Positive Reappraisal is a coping strategy that can protect mental health in situations of stress associated with suicidal risk of the rural population, farmers, and agricultural workers.

Correlation between MAMMI-PET findings and anatomopathological outcomes in breast cancer patients.

OBJECTIVE: Imaging tests are a key element in the preoperative diagnosis of patients with breast cancer. Whole-body PET-computed tomography (PET/CT) breast studies have a limited spatial resolution, although dedicated breast PET (dbPET) devices such as the Mammography with Molecular Imaging PET (MAMMI-PET), have an increased sensitivity to detect tumor foci, especially those smaller than 2 cm. The purpose of this study is to define the validity and reliability of this new device. METHODS: A prospective and analytical observational study was carried out in a sample of patients with histologically confirmed breast cancer who were treated at our hospital between January 2017 and November 2018. The anatomopathological study findings for the surgical pieces were used as gold standards and we calculated their concordance with the findings from the MAMMI-PET as well as the validity and reliability parameters for this test. RESULTS: Data from 32 patients and 44 lesions (36 malignant and 8 benign) were evaluated. The mean patient age was 51.50 ± 11.68 years. Twenty patients had received neoadjuvant chemotherapy (NACT). The technique concordance rate was weak ( K = 0.349, P = 0.001) and was 84.3% for benign lesions and 62.6% for malignant ones. The MAMMI-PET sensitivity was 75%, whereas its specificity was 57.1%; the positive predictive value was 81.8% and the negative predictive value was 47.1%, with an overall precision of 70%. The MAMMI-PET sensitivity was higher in patients who had not undergone NACT and was significantly higher in patients with luminal B breast cancer compared to the luminal A subtype. CONCLUSION: The MAMMI-PET device had acceptable sensitivity and a high positive predictive value for the preoperative evaluation of patients with breast cancer; it was especially useful for lesions whose diagnosis with other imaging tests had been doubtful.

Emotional Impact of Graphic Health Warnings on Tobacco Packaging: Analysis of Their Content.

The use of graphic health warnings (GHWs) on tobacco packaging is one of the most widely used public health strategies worldwide, but there is little evidence of the emotional impact of its content and craving they generate. The objective of the present study was to evaluate the emotional and craving responses to GHW content. The study included 300 men and women of different ages (adolescents, young adults, and adults), both smokers and non-smokers. We evaluated the participants' emotional and craving responses to 16 GHWs with different content (i.e., cancer, cardiovascular disease, abortion, and childhood illness). We analyzed the effects of sex, smoking status, and age. GHWs exhibited the capacity to elicit aversive emotional states, with low levels of arousal and high levels of dominance and did not produce craving. GHWs that showed images of cancer and abortion had the greatest emotional impact. Non-smoking adolescent females experienced the greatest emotional impact of GHWs. The results suggest that GHWs effectively reduce the attractiveness of cigarette packages and discourage consumption, and increasing the size of GHWs may favor avoidance of the package. GHWs that depicted explicit threats had a greater emotional impact, especially in women.

Two-Step Strategy for Optimizing the Preoperative Classification of Adnexal Masses in a University Hospital, Using International Ovarian Tumor Analysis Models: Simple Rules and Assessment of Different NEoplasias in the adneXa Model.

OBJECTIVES: To evaluate the performance of a two-step strategy compared with the International Ovarian Tumor Analysis (IOTA) - Assessment of Different NEoplasias in the adneXa (ADNEX) model for preoperative classification of adnexal masses. METHODS: An ambispective diagnostic accuracy study based on ultrasound data collected at one university hospital between 2012 and 2018. Two ultrasonographers classified the adnexal masses using IOTA Simple Rules (first step). Not classifiable masses were evaluated using the IOTA ADNEX model (second step). Also, all masses were classified using the IOTA ADNEX model. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), positive likelihood ratio (LR+) and negative likelihood ratio (LR-), and receiver operating characteristic (ROC) curve were estimated. A P value of <.05 was used to determine statistical significance. RESULTS: The study included 548 patients and 606 masses. Patients' median age was 41 years with an interquartile range between 32 and 51 years. In the first step, 89 (14%) masses were not classifiable. In the second step, 55 (61.8%) masses were classified as malignant. Furthermore, for the totality of 606 masses, the IOTA ADNEX model estimated the probability that 126 (20.8%) masses were malignant. The two-step strategy had a sensitivity, specificity, PPV, NPV, LR+, LR-, and ROC curve of 86.8%, 91.01%, 51.9%, 98.4%, 9.7, 0.1, and 0.889, respectively; compared to IOTA ADNEX model that had values of 91.8%, 87.16%, 44.4%, 99%, 7.1, 0.09, and 0.895, respectively. CONCLUSION: The two-step strategy shows a similar diagnostic performance when compared to the IOTA ADNEX model. The IOTA ADNEX model involves only one step and can be more practical, and thus would be recommended to use.

Las adolescentes frente a la decisión de interrumpir un embarazo en un contexto de aborto legal / Adolescents faced with the decision to terminate a pregnancy in a context of legal abortion / As adolescentes frente à decisão de interromper uma gravidez em um contexto de aborto legal

El artículo presenta resultados de una investigación sobre las experiencias de las adolescentes que decidieron interrumpir su embarazo en el marco de los servicios legales de aborto en Montevideo (Uruguay), realizada entre los años 2016 y 2018. Su objetivo principal fue examinar el proceso de toma de decisión y el acceso al aborto legal, desde la perspectiva de las propias adolescentes. Ello implicó analizar circunstancias, motivaciones y personajes que influenciaron en la toma de la decisión y cómo ésta se tramitó en el servicio de salud. Se diseñó un estudio transversal de tipo exploratorio y descriptivo, basado en metodología cualitativa. La técnica principal que se utilizó para la recolección de la información fue la entrevista semidirigida, se entrevistó a 14 adolescentes entre 17 y 19 años de edad que interrumpieron voluntariamente un embarazo en los servicios públicos de salud. Los motivos para abortar dan cuenta del peso que tienen las razones socialmente aceptadas, incorporadas como motivos propios. Se observó que la madre juega un papel importante como referente en la decisión. Las adolescentes manifestaron tomar la decisión de abortar antes de haber concurrido al servicio de salud. Se destaca el papel positivo de la existencia de un marco legal que habilita servicios de aborto voluntario. Los resultados contribuyen a comprender los procesos que viven las adolescentes frente a una decisión vital difícil, el rol de la familia, en particular de la figura materna, el lugar que tiene el marco legal en la toma de la decisión, el peso del estigma y la sanción moral, y las expectativas respecto de la atención en servicios de salud.

The article presents the results of a study on the experiences of adolescents that decided to terminate a pregnancy in the context of legal abortion services in Montevideo, Uruguay, from 2016 to 2018. The main objective was to examine the decision-making process and access to legal abortion from the perspective of the adolescent girls themselves. This involved analyzing circumstances, motives, and persons that influenced the decision and the ways this was handled in the health services. A cross-sectional, exploratory, and descriptive study was designed, based on a qualitative methodology. The main technique used for collecting the information was a semi-structured interview with 14 adolescents 17 to 19 years of age who had voluntarily terminated a pregnancy in public healthcare services. The motives for the abortion reveal the weight of socially accepted reasons, incorporated as their own. The interviews showed that the adolescent's mother plays an important role as the reference for the decision. The adolescents reported that they had made the decision to have the abortion before going to the health service. The results highlight the positive role of a legal framework that enables voluntary abortion services. The results help understand the experiences of adolescents facing a difficult life decision, the family's role, particularly that of the adolescent's mother, the legal framework's place in the decision, the weight of stigma and moral sanctions, and expectations towards care in health services.

O artigo apresenta os resultados de uma pesquisa, desenvolvida entre 2016 e 2018, sobre as experiências de adolescentes que decidiram interromper a sua gravidez nas unidades de saúde para aborto legal em Montevidéu (Uruguai). Tinha como objetivo principal analisar o processo de tomada de decisão e o acesso ao aborto legal, do ponto de vista das próprias adolescentes. Isso envolvia avaliar as circunstancias, motivações e personagens que influenciaram a tomada de decisão e a forma como se deu no sistema de saúde. Foi construído um estudo transversal do tipo exploratório e descritivo baseado numa metodologia qualitativa. A técnica principal utilizada para a coleta de informação era a entrevista semiestruturada; foram entrevistadas 14 adolescentes entre 17 e 19 anos de idade, que tinham interrompido voluntariamente uma gravidez no sistema público de saúde. Os motivos para abortar refletem o peso das razões socialmente aceitas, incorporadas como motivos próprios. Observou-se que a mãe desempenha um papel relevante, como referente na decisão. As adolescentes afirmaram ter tomado a decisão de abortar antes de se dirigir à unidade de saúde. Destaca-se o papel positivo da existência de um marco legal que habilita serviços de aborto voluntário. Os resultados contribuem para o entendimento dos processos vivenciados pelas adolescentes diante de uma decisão vital difícil, o papel da família, em especial da figura materna, o lugar ocupado pelo marco legal na tomada da decisão, o peso do estigma e da sanção moral, além das expectativas sobre o atendimento nas unidades de saúde.

Desarrollo de una política pública integral de prevención del embarazo en adolescentes en Uruguay / Development of a comprehensive public policy for adolescent pregnancy prevention in Uruguay / Desenvolvimento de uma política pública abrangente de prevenção da gravidez na adolescência no Uruguai

RESUMEN Se presentan las principales características y logros de la Estrategia Nacional e Intersectorial para la Prevención del Embarazo en Adolescentes, implementada en Uruguay entre 2016 y 2020. Este proceso se desarrolló en un contexto en el que el embarazo no intencional en adolescentes continúa siendo un problema social relevante para Uruguay y la Región, por lo que se requieren políticas públicas integrales, sostenidas y basadas en evidencias científicas. En Uruguay, la fecundidad adolescente se ha mantenido en niveles elevados por más de una década. Además de la acción intersectorial del Gobierno y la sociedad civil, la estrategia aprobada contó con asesoramiento científico desde el ámbito académico y la cooperación técnica y financiera de organismos regionales e internacionales. Las acciones y medidas adoptadas se basan en una visión socio-ecológica, con sensibilidad cultural, enfoque transformador de género y perspectiva de derechos humanos. Entre las barreras más importantes están las normas sociales que valoran la maternidad como el principal proyecto de vida para las mujeres que viven en contextos de pobreza, los estereotipos de género —el embarazo como una responsabilidad exclusiva de las adolescentes, sin involucrar a los adolescentes varones—, el estigma del aborto, la insuficiente oferta de servicios de salud sexual y reproductiva, y la resistencia a visibilizar el embarazo en niñas menores de 15 años víctimas de la violencia estructural e intrafamiliar. Es necesario asegurar la continuidad de las políticas públicas, ajustadas a un enfoque de género y de derechos humanos, y que se tomen en cuenta los nuevos escenarios, como el que impone la pandemia por COVID-19.

ABSTRACT This article presents the main characteristics and achievements of Uruguay's National and Intersectoral Strategy for Prevention of Adolescent Pregnancy, implemented from 2016 to 2020. This strategy was implemented in a context in which unintentional adolescent pregnancy continues to be a major social problem for Uruguay and the Region, necessitating comprehensive, sustained, and evidence-based public policies. In Uruguay, adolescent fertility rates have remained high for over a decade. In addition to intersectoral action by government and civil society, the strategy received scientific assistance from the academic community, and technical and financial cooperation from regional and international organizations. Its actions and measures were adopted based on a socio-ecological vision, with cultural sensitivity, a gender-transformative approach, and a human rights perspective. Major barriers include social norms that value maternity as the main life project for women living in poverty, gender stereotypes (pregnancy as the exclusive responsibility of adolescent girls, without involving adolescent boys), the stigma of abortion, a lack of sexual and reproductive health services, and resistance to raising the visibility of pregnancy in girls under 15 years of age who are victims of structural and family violence. It is necessary to ensure the continuity of public policies--adjusted to a gender and human-rights approach--that take into account new scenarios such as the one imposed by the COVID-19 pandemic.

RESUMO Este artigo apresenta os principais aspectos e os resultados da Estratégia Nacional e Intersetorial para Prevenção da Gravidez na Adolescência, implementada no Uruguai entre 2016 e 2020. A gravidez não intencional na adolescência persiste como uma questão social importante no Uruguai e na Região, exigindo políticas públicas com base em evidências científicas que sejam abrangentes e permanentes. A fecundidade na adolescência no Uruguai tem se mantido elevada há mais de uma década. Além da ação intersetorial do governo e da sociedade civil, a estratégia aprovada recebeu orientação científica de entidades acadêmicas, e cooperação técnica e financeira de organismos regionais e internacionais. As ações e as medidas da estratégia foram elaboradas a partir de uma visão socioecológica, com sensibilidade cultural e enfoque transformador de gênero e uma perspectiva de direitos humanos. Entre as barreiras mais importantes enfrentadas estão as normas sociais que valorizam a maternidade como principal projeto de vida para a mulher que vive em situação de pobreza, os estereótipos de gênero (a gravidez é vista como responsabilidade exclusiva da adolescente, sem envolver o parceiro adolescente), o estigma do aborto, a oferta insuficiente de serviços de saúde sexual e reprodutiva, e a resistência a dar visibilidade à gravidez de menores de 15 anos que são vítimas de violência estrutural e intrafamiliar. É necessário garantir a continuidade das políticas públicas que incorporem uma perspectiva de gênero e direitos humanos, e que sejam adaptadas aos novos cenários da pandemia de COVID-19.

Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies.

One of the main features of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease is the amyloidogenic behavior of disease-specific proteins including amyloid ß, tau, α-synuclein, and mutant Huntingtin which participate in the formation, accumulation, and deposition of toxic misfolded aggregates. Consequently, these proteins not only associated with the progress of their respective neurodegenerative pathologies but also qualify as disease-specific biomarkers. The aim of using natural polyphenols is to target amyloid-dependent proteopathies by decreasing free radical damage and inhibiting and dissolving amyloid fibrils. We explore the effectiveness of the polyphenols epigallocatechin-3-gallate, oleuropein aglycone, and quercetin on their ability to inhibit aggregation of amyloid ß, tau, and α-synuclein and mitigate other pathological features for Alzheimer's disease and Parkinson's disease. The analysis was carried from in vitro and cell line studies to animal models and clinical trials. This Review describes the use of phytochemical compounds as prophylactic agents for Alzheimer's disease, Parkinson's disease, and other proteopathies.

Moderately elevated first trimester fasting plasma total homocysteine is associated with increased probability of miscarriage. The Reus-Tarragona Birth Cohort Study.

The association between elevated early pregnancy fasting plasma total homocysteine (tHcy) and miscarriage risk was investigated prospectively in participants (n = 544) from the Reus-Tarragona Birth Cohort study. Pregnancy was confirmed before 12 gestational weeks (GW) by ultrasound scan and a fasting blood sample collected. Pregnancies with complications other than miscarriages were excluded. Miscarriages were diagnosed by ultrasound scan and gestational age at the time of miscarriage estimated by embryo size, where possible. Cases in which blood samples were collected more than a week after the miscarriage, or the miscarriage was of known cause, were excluded. Fasting plasma folate, vitamin B12, tHcy, cotinine (biomarker of smoking), red blood cell (RBC) folate, MTHFR 677C > T (rs1801133) and SLC19A1 80G>A (rs1051266) genotypes were determined. The exposed group consisted of participants with first trimester tHcy ≥ P90 (7.1 µmol/L) (n = 57) and unexposed of those with tHcy < P90 (n = 487). Adherence to folic acid supplement recommendations, plasma folate, plasma vitamin B12, RBC folate and prevalence of optimal RBC folate status (≥ 906 µmol/L) were lower in the exposed compared to unexposed group. The prevalences of the MTHFR 677 TT genotype and miscarriage were higher in the exposed group. The relative risks (95% CI) of pregnancy ending in miscarriage were 2.5 (1.1, 5.7) and 2.1 (1.0, 4.5) for participants in the high tHcy and suboptimal RBC folate groups (compared to the reference groups) respectively. Adherence to folic acid supplement recommendations was positively associated, while the MTHFR 677 TT versus CC genotype and smoking versus non-smoking were negatively associated, with RBC folate status.

Major ambulatory surgery in breast diseases. / Cirugía mayor ambulatoria en patología mamaria.

INTRODUCTION: The use of ambulatory surgery (AS) for breast pathology (BP) has increased. The objective of this study is to analyse a group of patients treated surgically for breast pathology in order to evaluate its quality and security in a MAS setting in 2017. METHODS: A retrospective review of all patients undergoing breast surgery was conducted within an AS programme from January to December 2017 in Consorcio Hospital General Universitario of Valencia (CHGUV). The study analysed the number of patients, exclusion reasons, type of surgical procedures, evolution of substitution rate (SR), rate and causes of conversion to admission, postoperative complications, motives for not being included in the ambulatory programme and the satisfaction rate of the patients treated with ambulatory surgery. This has been compared with a 2013 group. RESULTS: In 2017, 396 procedures for BP were performed: 170 for benign and 226 for malignant disease. The SR for the global mammary pathology was 72.8%. The SR for benign pathology was 93.4% and the SR for malignant pathology was 57.2%, which has increased in recent years from 45.4% in 2013. The unexpected hospitalization rate (HR) of malignant pathologies was 14.1%, while the HR in benign pathologies was 0.6%. Patients hospitalized for malignant pathologies presented higher complications (17%) than ambulatory patients (8.5%) and benign pathologies (6.5%). CONCLUSIONS: At the CHGUV, the SR has steadily increased in malignant pathologies. The unexpected hospitalization rate is determined by perioperative sentinel lymph node biopsy results. AS for the treatment of mammary pathology is efficient and safe.

Búsqueda etiológica de ACV en salas de medicina del Hospital Pasteur, Montevideo - Uruguay. Julio - setiembre 2019 / Aetiological search for stroke in medical rooms of the Pasteur Hospital, Montevideo - Uruguay. July - September 2019 / Pesquisa etiológica da ACV em salas médicas do Hospital Pasteur, Montevideo - Uruguai. Julho - setembro 2019

Resumen: Introducción: El ataque cerebrovascular (ACV) es una lesión del parénquima cerebral por compromiso vascular, pudiendo ser hemorrágico o isquémico. Presenta alta morbimortalidad, siendo la segunda causa de muerte a nivel mundial, tercera en nuestro país, que genera además elevados costos sanitarios. Conocer las etiologías más frecuentes de esta patología, su asociación con factores de riesgo y el tratamiento realizado, podría contribuir a la correcta elaboración de estrategias de prevención primaria y secundaria. Objetivos: Conocer la/s etiología/s del ACV en pacientes internados en salas de medicina interna del Hospital Pasteur, sus características epidemiológicas; la asociación entre los factores de riesgo, paraclínica solicitada y tratamiento sugerido al alta. Metodología: Estudio descriptivo, transversal, observacional. Se incluyeron pacientes mayores de 18 años con diagnóstico de ACV internados en las salas de medicina del Hospital Pasteur, entre el 15 de Julio y el 30 de Septiembre del 2019. Se realizó la recolección de datos a partir de las historias clínicas por medio de un formulario precodificado, que analizó variables categóricas como factores de riesgo, presentación clínica, paraclínica solicitada y tratamiento. Resultados y discusión: Se incluyeron 30 pacientes, 18 de sexo femenino. La media de edad fue 70,48 años. La naturaleza isquémica predominó en un 90%. Los principales factores de riesgo fueron hipertensión arterial, dislipemia, diabetes mellitus y tabaquismo. El síndrome piramidal fue la forma de presentación clínica más frecuente. La etiología más prevalente fue de causa indeterminada, seguida por la ateroesclerótica y cardioembólica. En algunos pacientes no se realizó el algoritmo diagnóstico completo. El tratamiento realizado fue el adecuado de acuerdo a las causas planteadas. Conclusiones: La etiología más frecuente fue de causa indeterminada, seguida por la aterotrombótica. Los factores de riesgos más prevalentes fueron la hipertensión arterial, la dislipemia, la diabetes mellitus y el tabaquismo. La mayoría de los pacientes tenían más de 3 factores de riesgo asociados, de esta forma concluimos que la sumatoria de factores de riesgo incrementa la incidencia de ACV.

Abstract: Introduction: A stroke is a parenchymal cerebral lesion due to vascular compromise. This could be either hemorrhagic or ischemic. It presents high morbidity and mortality, being the second cause of death in the world and third in Uruguay, causing elevated health expenses. Recognizing the most frequent etiologies, their association with different risks factors and treatments applied could help to create better primary and secondary prevention strategies. Objectives: recognized stroke`s etiologies in patients hospitalized in Hospital Pasteur`s rooms, their epidemiologic characteristics, risk factors associated, the requested paraclinic and the treatment before they leave the hospital. Methods: Descriptive, observational and transversal study. We included patients older than 18 years old, with a stroke diagnosis, admitted into Hospital Pasteur medical`s rooms, between July 15 and September 30, 2019. Data were collected from medical records by accepting an informed consent, which analyzed variables such as risk factors, clinical presentation, requested preclinical and treatment. Results and discussion: 30 patients were included, 18 were female. The average age was 70,48 years. Ischemic strokes were predominated by 90%. Hypertension, dyslipidemia, diabetes mellitus and smoking were the predominant risk factors. Pyramidal syndrome was the most frequent clinical presentation. Undetermined stroke was the principal etiology, followed by atherosclerotic and cardioembolic. There were some patients that the algorithm was not completed. Treatments were adequate according to the causes. Conclusions: The most frequent etiology was the undetermined cause, followed by atherothrombotic. Prevalent risk factors were hypertension, dyslipidemia, DM and smoking. Most of the patients had more than 3 associated risk factors, so we conclude that the sum of risk factors increases the incidence of stroke.

Resumo: Introdução: O ataque cerebrovascular (AVC) é uma lesão do parênquima cerebral por comprometimento vascular, podendo ser hemorrágico ou isquêmico. Apresenta alta morbimortalidade, sendo a segunda principal causa de morte no mundo, a terceira em nosso país, o que também gera altos custos de saúde. Conhecer as etiologias mais frequentes dessa patologia, sua associação com fatores de risco e o tratamento realizado, poderia contribuir para o correto desenvolvimento de estratégias de prevenção primária e secundária. Objetivos: Conhecer a etiologia / s do AVC em pacientes internados nas salas de medicina interna do Hospital Pasteur, suas características epidemiológicas; a associação entre fatores de risco, solicitou tratamento paraclínico e sugerido no momento da alta. Metodologia: Estudo descritivo, transversal, observacional. Entre 15 de julho e 30 de setembro de 2019, foram incluídos pacientes com idade superior a 18 anos com diagnóstico de AVC admitidos nas salas médicas do Hospital Pasteur. Os dados foram coletados dos prontuários por meio de formulário pré-codificado, que analisou variáveis ​​categóricas como fatores de risco, apresentação clínica, solicitação paraclínica e tratamento. Resultados e discussão: foram incluídos 30 pacientes, 18 do sexo feminino. A idade média foi de 70,48 anos. A natureza isquêmica predominou em 90%. Os principais fatores de risco foram pressão alta, dislipidemia, diabetes mellitus e tabagismo. A síndrome piramidal foi a apresentação clínica mais frequente. A etiologia mais prevalente foi de causa indeterminada, seguida de aterosclerótica e cardioembólica. Em alguns pacientes, o algoritmo diagnóstico completo não foi realizado. O tratamento foi adequado de acordo com as causas. Conclusões: A etiologia mais frequente foi de causa indeterminada, seguida de aterotrombótica. Os fatores de risco mais prevalentes foram hipertensão, dislipidemia, DM e tabagismo. A maioria dos pacientes apresentou mais de três fatores de risco associados, concluindo que a soma dos fatores de risco aumenta a incidência de acidente vascular cerebral.

Diagnósticos diferenciales de trastorno del espectro autista y aporte de ADOS y ADIR-R como herramientas complementarias / Differentials diagnosis of autism spectrum disorders and contribution of ADOS and ADD-R as complementary tools

INTRODUCCIÓN: El diagnóstico de los Trastornos del Espectro Autista (TEA) es clínico y complejo por la dificultad de interpretar los síntomas, las frecuentes comorbilidades, la heterogeneidad clínica y la ausencia de indicadores específicos. Múltiples instrumentos se han desarrollado para su evaluación, destacando la Escala de Observación para el Diagnóstico del Autismo (ADOS) y la Entrevista para Diagnóstico de Autismo, versión revisada (ADI-R); la sensibilidad y especificidad de estos tests es alta, más aún si se utilizan en conjunto. OBJETIVO: Evaluar la utilidad de ADI-R y ADOS como herramientas complementarias para el diagnóstico de TEA, en particular cuando resultan discrepantes del diagnóstico clínico. METODOLOGÍA: Estudio retrospectivo, de revisión de registro clínico de 44 pacientes (36 varones), de edad promedio 6,7 años, por sospecha de TEA entre 6/2015-05/2017. Se aplicó ADI-R+ADOS-2, siendo ciega respecto a la hipótesis clínica inicial. El diagnóstico definitivo se plantea tras el seguimiento de largo plazo (6-58 meses). RESULTADOS: En 37 de 44 pacientes, el diagnóstico clínico inicial fue TEA; en los 7 restantes otros diagnósticos de trastornos del neurodesarrollo y psiquiátricos. ADI-R+ADOS-2 fueron concordantes con el diagnóstico clínico en 39(89%), en 7 descartando y en 32 confirmando el diagnóstico de TEA, añadiendo en estos últimos el grado de severidad. En 5 casos hubo discordancia entre el diagnóstico clínico inicial y los tests; en los 5 casos el especialista planteó TEA y los tests lo refutaron, comprobándose tras la evolución en largo plazo lo planteado por los test en 4 casos y por el clínico en 1 caso. Los más frecuentes diagnósticos diferenciales fueron Trastorno de Comunicación Social, Trastorno por déficit de atención e hiperactividad comórbido con Trastorno del desarrollo de lenguaje y Trastornos ansiosos. CONCLUSIONES: El diagnóstico de TEA debe ser clínico, hecho por un médico especialista que considere una multiplicidad de variables. ADI-R+ADOS2 resultaron herramientas complementarias útiles, particularmente en los casos en que descartaron TEA, instando al equipo tratante a la búsqueda de diagnósticos diferenciales.

INTRODUCTION: The diagnosis of the autism spectrum disorders (ASD) is clinically and complex because of the difficulty of interpreting symptoms, frequent comorbidities, the clinical heterogeneity and the lack of specific indicators. Many instruments have been developed for evaluation, of which we highlight the scale of observation for the diagnosis of autism (ADOS) and the interview for diagnosis of autism, revised (ADI-R); the sensitivity and specificity of these tests is high, even more when they are used together. OBJECTIVE: To evaluate the usefulness of ADI-R and ADOS as complementary tools for the diagnosis of ASD, particularly when they are discrepant from the clinical diagnosis. METHODS: This is a retrospective study, a review of the clinical records of 44 patients (36 male), average age 6.7 years, with a suspicion of ASD between June 2015- May 2017. ADIR+ADOS-2 were applied blindly to the initial clinical hypothesis. The definitive diagnosis is certified after a long-term follow-up (6-58 months). RESULTS: In 37 of 44 patients the initial clinical diagnosis was ASD; in the remaining 7 other psychiatric and neurodevelopmental disorders were diagnosed. ADI-R+ADOS-2 were concordant with the clinical diagnosis in 39 (89%), excluding 7 and in 32 confirming the diagnosis of ASD, adding the degree of severity in the latter. In 5 cases there was discrepancy between the initial clinical diagnosis and tests; in these 5 cases the specialist suspected ASD and the tests disproved it; after the long-term follow-up the test's diagnosis was confirmed in 4 of the 5 cases, and in the remaining case the clinical diagnosis was confirmed. The most frequent differential diagnoses were social communication disorder, attention deficit hyperactivity disorder comorbid with language development disorder, and anxious disorders. CONCLUSIONS: The diagnosis of ASD should be clinical and made by a medical specialist who considers a multiplicity of variables. ADI-R+ADOS2 were complementary tools, particularly in cases in which ASD was rejected, urging the treating team to search for differential diagnosis.

Nivel de conocimiento de la ley de voluntad anticipada en población geriátrica en México / Level of knowledge of the Law of Living Will in geriatric population in Mexico

Introducción: Al aumentar la esperanza de vida se incrementa también la presencia de enfermedades crónicas degenerativas, que se caracterizan por ser incurables, progresivas e invariablemente fatales. Para proteger la autonomía de los enfermos terminales surgió en la Ciudad de México la Ley de Voluntad Anticipada, para respetar la decisión del paciente en fase terminal. Objetivo: Identificar el nivel de conocimiento de la población geriátrica respecto a la Ley de Voluntad Anticipada. Métodos: Estudio observacional, descriptivo, realizado en una Clínica de Medicina Familiar de septiembre a diciembre de 2016. Se empleó muestreo no probabilístico por conveniencia. Se calculó el tamaño de muestra con base en criterio de diferencia absoluta. Se utilizó estadística inferencial para relacionar las variables de estudio con el nivel de conocimiento, pruebas de chi cuadrado, exacta de Fisher y/o Kruskal Wallis. Nivel de significancia 0,05. Paquete estadístico SPSS. Resultados: Se entrevistaron 66 pacientes en total, el promedio de edad fue 79,74 años, el 72,2 por ciento tenía nivel de escolaridad básico. El 21,2 por ciento de la población sabía la existencia de la Ley de Voluntad Anticipada. En el análisis estadístico solo se obtuvo relación con significancia estadística entre el nivel de conocimiento acerca de la Ley de Voluntad Anticipada y la escolaridad de los pacientes para la mayoría de las preguntas. Conclusión: La Ley de Voluntad Anticipada es un recurso legal poco conocido en la población geriátrica, se deben establecer campañas de difusión así como sensibilizar al personal de salud para abordarla en la consulta diaria(AU)

Introduction: Increasing life expectancy also increases the presence of chronic degenerative diseases, which are characterized by being incurable, progressive and invariably fatal. The Law of Advance Will arose in Mexico City to protect the autonomy and respect the decision of patients in terminal stages. Objective: To identify the level of knowledge of the geriatric population regarding to the Law of Living Will. Methods: Observational, descriptive study performed in a Family Medicine's Clinic from September to December, 2016. A non-probabilistic sampling was used by convenience. The sample size was calculated based on the absolute difference's criteria. Inferential statistics were used to relate the study variables to the level of knowledge, and the Chi Square, exact Fisher and/or Kruskal Wallis tests. The significance level was of 0.05. It was used the SPSS statistical package. Results: 66 patients were interviewed in total, the average age was 79.74 years, 72.2 percent of them had basic level of schooling. 21.2 percent of the population knew about the existence of the Law of Living Will. The statistical analysis only obtained a relationship with statistical significance between the level of knowledge about the Law of Living Will and the schooling of patients for most of the questions. Conclusion: Law of Living Will is a little-known legal resource in the geriatric population and outreach campaigns should be established as well as sensitizing health personnel to address it in the daily consultation(AU)