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Introducción: El proyecto BIOBADASAR (Registro argentino deeventos adversos con tratamientos biológicos en reumatología)comenzó en agosto de 2010, para recabar información a largo plazosobre los eventos adversos en tratamientos biológicos en pacientescon enfermedades reumáticas en la práctica clínica cotidiana enArgentina.Pacientes y método: Se registraron datos de cada paciente,tratamientos y acontecimientos adversos relevantes o importantes.Los pacientes debían tener enfermedad diagnosticada y tratadacon un agente biológico. Cada caso se comparó con un control:un paciente con tratamiento no biológico con característicasdemográficas similares. Se analizaron los datos con análisis de lavarianza, con test de t de Student, Mann Whitney, test chi2, o testexacto de Fisher. El análisis de supervivencia de los tratamientoshasta su discontinuación o interrupción se realizó con el método deKaplan-Meier y test log-rank...
Background: BIOBADASAR (Argentine Registry of Adverse Eventsin Biological Treatments in Rheumatology) was started in August2010 to obtain long-term information of patients with rheumatic diseases,treatments and adverse events in everyday clinical practice.Patients and methods: Data on patients demographics,treatments and adverse events were collected. Patients had a diagnosisof a rheumatic disease and were treated with biological agent.To compare information, a control group was included, consisting ofpatients treated with similar demographic characteristics but treatedwith a non-biological agent. Data were analysed with Anova,Student´s t, Mann Whitney, chi2, Fisher´s exact tests, as appropriate.Survival analysis of treatments was performed with Kaplan-Meiercurves and log-rank test...
Assuntos
Tratamento Biológico , Doenças Reumáticas , ReumatologiaRESUMO
OBJECTIVE: To describe a case of giant renal calculus. METHODS/RESULTS: A 57-year-old female with a previous history of left renal calculus 30 years earlier, consulted for episodes of gross hematuria. The imaging studies showed a giant, spherical calculus, 9 cm in diameter, in the left renal pelvis with hydronephrosis and remaining renal parenchyma functioning. The patient refused surgery. CONCLUSION: Giant renal calculi may progress slowly, without symptoms and without abolishing renal function.
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Cálculos Renais/patologia , Idoso , Feminino , Humanos , Cálculos Renais/diagnóstico por imagem , RadiografiaRESUMO
The effect of muscle tissue from rats trained by swimming on the extracellular degradation of triglyceride (TG) rich particles has been studied in vitro. During incubation, there is a progressive decline of the TG concentration in the incubation medium. At the end of the incubation period (90 min), a significantly reduction in the TG levels (p < 0.05) is associated with a significant increase in the high-density lipoprotein (HDL) cholesterol level (p < 0.005). There are no significant changes in total cholesterol levels. The correlation of the TG decline with the HDL-cholesterol increase is significant (r = 0.695, p < 0.05, n = 25). The experimental model used here could be of great interest for the in vitro study of factors affecting lipid levels in plasma.
Assuntos
HDL-Colesterol/metabolismo , Músculos/metabolismo , Condicionamento Físico Animal , Triglicerídeos/metabolismo , Adulto , Análise de Variância , Animais , Biópsia , Feminino , Humanos , Técnicas In Vitro , Ratos , Ratos Wistar , NataçãoAssuntos
Neoplasias/epidemiologia , Doenças Profissionais/epidemiologia , Carcinógenos , Estudos de Casos e Controles , Causas de Morte , Estudos Transversais , Feminino , Humanos , Itália/epidemiologia , Masculino , Região do Mediterrâneo/epidemiologia , Neoplasias/induzido quimicamente , Doenças Profissionais/induzido quimicamente , Exposição Ocupacional , Ocupações , Sistema de Registros , Fatores de Risco , Espanha/epidemiologiaRESUMO
Four cases of aorto-pulmonary window are presented, diagnosed in the Section of Pediatric Cardiology during the last six years. The results obtained from clinic; ECG; X-ray; hemodinamic and angiographic studies are described. All of them were clinically diagnosed as left to right shunt through a persistent ductus arteriosus in two cases and of VSD the other two. The final diagnosis was made through cardiac cateterization in one case and at surgery in three. Two of the cases showed additional alterations, in one case it was a PDA, and the other a valvular aortic stenosis. All of them were operated, three successfully and one died immediately after operation. We consider that the study of this relatively rare cardiopaty deserves special attention, because of the similarity to other forms of left to right shunts. We insist on its difficult clinical dianose and the need of making a early diagnosis to do corrective surgery.