1.
Eur J Med Chem
; 38(1): 65-74, 2003 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12593917
RESUMO
Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). Most of them maintained their cytotoxicity at the microM level.