1.
Chem Commun (Camb)
; 57(25): 3147-3150, 2021 Mar 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33634803
RESUMO
Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across membranes in response to Δψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules.