RESUMO
Cutaneous metastases appear in 0.6% to 10.4% of malignant tumors and account for 2% of all cutaneous tumors. Metastasis to the skin may arise from progression of a known primary tumor or provide the first sign of an unsuspected one. Acral metastases are particularly unusual. Most derive from bone tumors. Clinical signs vary and the lesions generally resemble infection or inflammation, leading to diagnostic delays. When metástasis involves the fingers, the primary tumor is usually lung carcinoma. In contrast, toe involvement usually derives from a tumor in the genitourinary tract. A pathologic diagnosis in these cases is necessary and will suggest the location of the primary tumor. We report 2 cases of metástasis to the fingers. One is the first report of acral metástasis of a myoepithelial carcinoma of the breast. The other concerns acral metástasis as the first sign of lung carcinoma.
Assuntos
Carcinoma de Células Escamosas/secundário , Dedos/patologia , Mioepitelioma/secundário , Neoplasias Cutâneas/secundário , Idoso , Neoplasias da Mama/patologia , Evolução Fatal , Feminino , Humanos , Neoplasias Pulmonares/patologia , Masculino , Recidiva Local de NeoplasiaAssuntos
Apêndice Atrial , Procedimentos Cirúrgicos Cardíacos , Fibrossarcoma , Neoplasias Cardíacas , Adulto , Apêndice Atrial/diagnóstico por imagem , Apêndice Atrial/patologia , Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Procedimentos Cirúrgicos Cardíacos/métodos , Ecocardiografia/métodos , Evolução Fatal , Feminino , Fibrossarcoma/diagnóstico por imagem , Fibrossarcoma/patologia , Fibrossarcoma/fisiopatologia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/fisiopatologia , Humanos , Invasividade Neoplásica , Carga TumoralAssuntos
Antígenos CD/análise , Antígenos de Neoplasias/análise , Biomarcadores Tumorais/análise , Imunofenotipagem , Micose Fungoide/patologia , Neoplasias Cutâneas/patologia , Subpopulações de Linfócitos T/patologia , Idoso de 80 Anos ou mais , Antígenos CD8/análise , Diagnóstico Diferencial , Progressão da Doença , Evolução Fatal , Genes Codificadores da Cadeia gama de Receptores de Linfócitos T , Humanos , Antígeno Ki-1/análise , Transtornos Linfoproliferativos/diagnóstico , Masculino , Micose Fungoide/diagnóstico , Neoplasias Cutâneas/diagnóstico , Úlcera Cutânea/etiologia , Subpopulações de Linfócitos T/químicaRESUMO
Interstitial granulomatous dermatitis and arthritis (IGDA) is an uncommon clinicopathological condition that may occur in association with a number of systemic disorders. We present a novel case of IGDA in association with oesophageal squamous cell carcinoma (SCC). A 67-year-old man with a 3-month history of arthritis presented with several erythematous indurated plaques on his lateral trunk and arms. An oesophagogastroduodenoscopy showed an irregular mass 20 mm in size in the proximal third of the oesophagus, and on histopathological examination of a biopsy, the mass was identified as a poorly differentiated SCC. Histopathological examination of a skin biopsy found features consistent with interstitial granulomatous dermatitis. The combination of clinicopathological correlation and laboratory findings led to the diagnosis of IGDA. This association has not been previously described, to our knowledge.