Multi-scale nested UNet with transformer for colorectal polyp segmentation.

BACKGROUND: Polyp detection and localization are essential tasks for colonoscopy. U-shape network based convolutional neural networks have achieved remarkable segmentation performance for biomedical images, but lack of long-range dependencies modeling limits their receptive fields. PURPOSE: Our goal was to develop and test a novel architecture for polyp segmentation, which takes advantage of learning local information with long-range dependencies modeling. METHODS: A novel architecture combining with multi-scale nested UNet structure integrated transformer for polyp segmentation was developed. The proposed network takes advantage of both CNN and transformer to extract distinct feature information. The transformer layer is embedded between the encoder and decoder of a U-shape net to learn explicit global context and long-range semantic information. To address the challenging of variant polyp sizes, a MSFF unit was proposed to fuse features with multiple resolution. RESULTS: Four public datasets and one in-house dataset were used to train and test the model performance. Ablation study was also conducted to verify each component of the model. For dataset Kvasir-SEG and CVC-ClinicDB, the proposed model achieved mean dice score of 0.942 and 0.950 respectively, which were more accurate than the other methods. To show the generalization of different methods, we processed two cross dataset validations, the proposed model achieved the highest mean dice score. The results demonstrate that the proposed network has powerful learning and generalization capability, significantly improving segmentation accuracy and outperforming state-of-the-art methods. CONCLUSIONS: The proposed model produced more accurate polyp segmentation than current methods on four different public and one in-house datasets. Its capability of polyps segmentation in different sizes shows the potential clinical application.

Mesenchymal stem cells alleviate sepsis-induced acute lung injury by blocking neutrophil extracellular traps formation and inhibiting ferroptosis in rats.

Acute lung injury (ALI) is one of the most serious complications of sepsis, characterized by high morbidity and mortality rates. Ferroptosis has recently been reported to play an essential role in sepsis-induced ALI. Excessive neutrophil extracellular traps (NETs) formation induces exacerbated inflammation and is crucial to the development of ALI. In this study, we explored the effects of ferroptosis and NETs and observed the therapeutic function of mesenchymal stem cells (MSCs) on sepsis-induced ALI. First, we produced a cecal ligation and puncture (CLP) model of sepsis in rats. Ferrostain-1 and DNase-1 were used to inhibit ferroptosis and NETs formation separately, to confirm their effects on sepsis-induced ALI. Next, U0126 was applied to suppress the MEK/ERK signaling pathway, which is considered to be vital to NETs formation. Finally, the therapeutic effect of MSCs was observed on CLP models. The results demonstrated that both ferrostain-1 and DNase-1 application could improve sepsis-induced ALI. DNase-1 inhibited ferroptosis significantly in lung tissues, showing that ferroptosis could be regulated by NETs formation. With the inhibition of the MEK/ERK signaling pathway by U0126, NETs formation and ferroptosis in lung tissues were both reduced, and sepsis-induced ALI was improved. MSCs also had a similar protective effect against sepsis-induced ALI, not only inhibiting MEK/ERK signaling pathway-mediated NETs formation, but also alleviating ferroptosis in lung tissues. We concluded that MSCs could protect against sepsis-induced ALI by suppressing NETs formation and ferroptosis in lung tissues. In this study, we found that NETs formation and ferroptosis were both potential therapeutic targets for the treatment of sepsis-induced ALI, and provided new evidence supporting the clinical application of MSCs in sepsis-induced ALI treatment.

The applications of miniprobe endoscopic ultrasonography in the diagnosis and treatment of colorectal submucosal lesions.

Objectives: To evaluate the efficacy of miniprobe endoscopic ultrasonography for the diagnosis and adjuvant treatment of patients with colorectal submucosal lesions. METHODS: The retrospective study was conducted at the Beijing Chao-Yang Hospital, Capital Medical University, China, and comprised data from January 1, 2016, to July 31, 2021, related to patients of either gender with colorectal submucosal lesions who underwent miniprobe endoscopic ultrasonography. The findings were compared with biopsy specimens and clinical diagnoses. Diagnostic features of miniprobe endoscopic ultrasonography were assessed along with its accuracy. Data was analysed using R 4.1.2. RESULTS: Of the 237 patients, 121(51.1%) were female and 116(48.9%) were male. The overall mean age was 55.6±12.9 years. Miniprobe endoscopic ultrasonography successfully imaged all 237(100%) colorectal submucosal lesions, and 188(79.3%) had consistent results compared to histopathological findings. The majority of lesions were <10mm 102(43.4%) or 10-19mm 84(35.7%) in size. Those detected with high echogenicity were 126(53.2%) and those with low/low-medium echogenicity were 83(35.0%). Tumour size 10-19mm and uneven echo quality significantly increased the accuracy of miniprobe endoscopic ultrasonography (p<0.05). CONCLUSIONS: Miniprobe endoscopic ultrasonography was able to provide precise information about the size, layer of origin, echogenicity and border of colorectal submucosal lesions, and had a high accuracy in the differential diagnosis of such lesions.

Identification of TLN1 as a prognostic biomarker to effect cell proliferation and differentiation in acute myeloid leukemia.

The protein Talin1 encoded by the TLN1 gene is a focal adhesion-related protein that binds to various cytoskeletal proteins and plays an important role in cell adhesion and movement. Recent studies have shown that it is overexpressed in prostate cancer, liver cancer, and oral squamous cell carcinoma, and is closely related to tumor progression and metastasis. This study integrated bioinformatics and functional analysis to reveal the prognosis and potential functions of TLN1 in AML. The results showed that the expression level of TLN1 was abnormally increased in AML and localized in the cell membrane and cytoplasm, and TLN1 is a significant prognostic indicator of overall survival (OS). Enrichment analysis of related genes showed that TLN1 is related to neutrophil mediated immunity, neutrophil activation and may regulate important signal pathways in hematological tumors including tyrosine kinase receptor, FLT3 and PIK3/AKT. The PPI network shows that TLN1 and MYH9 may be involved in the process of AML tumors together with PIP5K1C, ROCK1, S100A4, MY01A and WAC. Immune infiltration analysis explains that TLN1 is associated with multiple immune cells and may be an important immune marker in AML. Furthermore, molecular biology experiments confirmed that TLN1 is related to the proliferation, differentiation and cycle of AML cells. Silencing TLN1 can inhibit the proliferation of AML cells and promote differentiation through the Talin1/P-AKT/CREB signaling pathway.

Emerging concerns of VOCs and SVOCs in coking wastewater treatment processes: Distribution profile, emission characteristics, and health risk assessment.

In this study, the distribution profiles, emission characteristics, and health risks associated with 43 volatile and semi-volatile organic compounds, including 15 phenols, 18 polycyclic aromatic hydrocarbons (PAHs), 6 BTEX, and 4 other compounds, were determined in the wastewater treatment plant (WWTP) of a coking factory (plant C) and the succeeding final WWTP (central WWTP). Total phenols with a concentration of 361,000 µg L-1 were the predominant compounds in the influent wastewater of plant C, whereas PAHs were the major compounds in the final effluents of both coking WWTPs (84.4 µg L-1 and 30.7 µg L-1, respectively). The biological treatment process in plant C removed the majority of volatile organic pollutants (94.1%-99.9%). A mass balance analysis for plant C showed that biodegradation was the main removal pathway for all the target compounds (56.6%-99.9%) except BTEX, chlorinated phenols, and high molecular weight (MW) PAHs. Chlorinated phenols and high MW PAHs were mainly removed via sorption to activated sludge (51.8%-73.2% and 60.2%-75.9%, respectively). Air stripping and volatilization were the dominant mechanisms for removing the BTEX compounds (59.8%-73.8%). The total emission rates of the detected volatile pollutants from plant C and the central WWTP were 1,640 g d-1 and 784 g d-1, respectively. Benzene from the equalization basins of plant C and the central WWTP corresponded to the highest inhalation carcinogenic risks (1.4 × 10-3 and 3.2 × 10-4, respectively), which exceeded the acceptable level for human health (1 × 10-6) recommended by the United States Environmental Protection Agency. The results showed that BaP exhibited the highest inhalation non-cancer risk, with a hazard index ratio of 70 and 30 for plant C and the central WWTP, respectively. Moreover, the excess sludge generated during wastewater treatment should also be carefully handled because it adsorbed abundant PAHs and chlorinated phenols at coking plant C (58,000 µg g-1 and 3,500 µg g-1) and the central WWTP (622 µg g-1 and 54 µg g-1).

Improvement of Asia-Pacific colorectal screening score and evaluation of its use combined with fecal immunochemical test.

BACKGROUND: The Asia-Pacific Colorectal Screening (APCS) score is effective to screen high-risk groups of advanced colorectal neoplasia (ACN) patients but needs revising and can be combined with the fecal immunochemical test (FIT). This paper aimed to improve the APCS score and evaluate its use with the FIT in stratifying the risk of ACN. METHODS: This prospective and multicenter study enrolled 955 and 1201 asymptomatic Chinese participants to form the derivation and validation set, respectively. Participants received the risk factor questionnaire, colonoscopy and FIT. Multiple logistic regression was applied, and C-statistic, sensitivity and negative predictive values (NPVs) were used to compare the screening efficiency. RESULTS: A modified model was developed incorporating age, body mass index (BMI), family history, diabetes, smoking and drinking as risk factors, stratifying subjects into average risk (AR) or high risk (HR). In the validation set, the HR tier group had a 3.4-fold (95% CI 1.8-6.4) increased risk for ACN. The C-statistic for the modified score was 0.69 ± 0.04, and 0.67 ± 0.04 for the original score. The sensitivity of the modified APCS score combined with FIT for screening ACN high-risk cohorts was 76.7% compared with 36.7% of FIT alone and 70.0% of the modified APCS score alone. The NPVs of the modified score combined with FIT for ACN were 98.0% compared with 97.0% of FIT alone and 97.9% of the modified APCS score alone. CONCLUSIONS: The modified score and its use with the FIT are efficient in selecting the HR group from a Chinese asymptomatic population.

Enhanced anaerobic performance and SMD process in treatment of sulfate and organic S-rich TMBA manufacturing wastewater by micro-electric field-zero valent iron-UASB.

This study focused on investigating reactor performance, simultaneous methanogeneis and denitrifiction (SMD) process for treatment of a sulfate plus organic sulfur - rich 3,4,5-Triethoxybenzaldehyde (TMBA) manufacturing wastewater with variable COD/TSO42- (total sulfate) ratio by micro-electric field- zero-valent-iron (ZVI) UASB for 390 days. The initial COD/TSO42- was set as 1.42, 0.9 and 0.5, respectively by manually introducing sulfate. The experimental results indicated that micro-electric field- zero-valent-iron UASB was an attractive integrated option for satisfactory COD removal, nitrate reduction and a reasonable methane yield rate even at COD/TSO42- as low as 0.9. Further declining the COD/TSO42- to 0.5 can result in a moderate inhibition of SMD process. The behavior of organic S release was not inhibited over the entire experimental period. Thus, surprisingly, sulfate concentration in the effluent was always higher than that in the influent. In comparison with sludge sample at Day-1, sludge at Day-390 was characterized with high abundant Tissierella Soehngenia, Anaerolinaceae and Brevundimonas diminuta, which played critical role in promising performance in COD abatement. The relatively low abundance of sulfate reducing bacteria (SRB) such as Desulfobulbus and Desulfomicrobium can explain the lower sulfate reduction efficiency in term of high concentration of sulfate plus released from organic S-rich compounds.

Rapid removal of polyacrylamide from wastewater by plasma in the gas-liquid interface.

Due to the severe restrictions imposed by legislative frameworks, the removal of polyacrylamide (PAM) rapidly and effectively from produced wastewater in offshore oilfields before discharge is becoming an urgent challenge. In this study, a novel advanced oxidation process based on plasma operated in the gas-liquid interface was used to rapidly decompose PAM, and multiple methods including viscometry, flow field-flow fractionation multi-angle light scattering, UV-visible spectroscopy, and attenuated total reflectance-Fourier transform infrared spectroscopy were used to characterize the changes of PAM. Under a discharge voltage of 25 kV and pH 7.0, the PAM concentration decreased from 100 to 0 mg/L within 20 min and the total organic carbon (TOC) decreased from 49.57 to 1.23 mg/L within 240 min, following zero-order reaction kinetics. Even in the presence of background TOC as high as 152.2 mg/L, complete removal of PAM (100 mg/L) was also achieved within 30 min. The biodegradability of PAM improved following plasma treatment for 120 min. Active species (such as O3 and H2O2) were produced in the plasma. Hydroxyl radical was demonstrated to play an important role in the degradation of PAM due to the inhibitory effect observed after the addition of an ·OH scavenger, Na2CO3. Meanwhile, the release of ammonia and nitrate nitrogen confirmed the cleavage of the acylamino group. The results of this study demonstrated that plasma, with its high efficiency and chemical-free features, is a promising technology for the rapid removal of PAM.

Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model.

Colorectal cancer (CRC) is the third most common cancer worldwide. Its incidence is still increasing, and the mortality rate is high. New therapeutic and prognostic strategies are urgently needed. It became increasingly recognized that the gut microbiota composition differs significantly between healthy people and CRC patients. Thus, identifying the difference between gut microbiota of the healthy people and CRC patients is fundamental to understand these microbes' functional roles in the development of CRC. We studied the microbial community structure of a CRC metagenomic dataset of 156 patients and healthy controls, and analyzed the diversity, differentially abundant bacteria, and co-occurrence networks. We applied a modified zero-inflated lognormal (ZIL) model for estimating the relative abundance. We found that the abundance of genera: Anaerostipes, Bilophila, Catenibacterium, Coprococcus, Desulfovibrio, Flavonifractor, Porphyromonas, Pseudoflavonifractor, and Weissella was significantly different between the healthy and CRC groups. We also found that bacteria such as Streptococcus, Parvimonas, Collinsella, and Citrobacter were uniquely co-occurring within the CRC patients. In addition, we found that the microbial diversity of healthy controls is significantly higher than that of the CRC patients, which indicated a significant negative correlation between gut microbiota diversity and the stage of CRC. Collectively, our results strengthened the view that individual microbes as well as the overall structure of gut microbiota were co-evolving with CRC.

Changes of flooding reagents' properties under simulated high temperature/pressure conditions in oil reservoirs and their impact on emulsion stability.

It is of great significance to know the fate of the polymers and surfactants used for enhanced oil recovery (EOR) in oil reservoirs at a relatively high temperature/pressure. In this paper, the changes of the properties of a polymer (partially hydrolyzed polyacrylamide, HPAM) and a surfactant (petroleum sulfonate, PS) were investigated under simulated oil reservoir conditions (a temperature of 45, 60 or 75 °C and a pressure of 10, 15 or 20 MPa). The impacts of the property changes to emulsion stability were also highlighted. The results showed that the hydrolysis degree of HPAM increased from 24.3% to 28.9%, 29.7% and 35.4%, whereas the molecular weight (M w) decreased from 7.60 × 106 g mol-1 to 5.43 × 106 g mol-1, 4.49 × 106 g mol-1 and 2.87 × 106 g mol-1 as a function of raising the temperature to 45, 60 and 75 °C with 20 MPa, respectively, for a duration of one week. However, the increased pressure showed obvious prevention effects on the degradation of HPAM M w in the investigated pressure range of 10-20 MPa. There were no changes in the oil-water interfacial tension for PS solutions after high temperature/pressure treatment. The stabilization ability of HPAM to the emulsion decreased markedly after treatment because of the decreased viscosity attributed to the reduction of molecular weight, while that of PS did not change. It is reasonable to speculate that the influence of back produced HPAM to the stability of EOR produced water will be quite different in different oil reservoirs because of the differences in reservoir temperature, pressure and retention time, and therefore different strategies should be considered in treating the produced water from EOR.

Effect of ultrasound on oil recovery from crude oil containing sludge.

To recover oil from crude oil containing sludge is still a research hot topic from the view of sustainability, in which ultrasonic has been proven to be an efficient and environment friendly technique. However, the effect of sludge characteristic on ultrasonic-assisted oil recovery efficiency is little known. In this study, the analysis of variance (ANOVA) was conducted based on six types of crude oily sludge with hydrophilicity and lipophilicity separately and five different ultrasonic operation factors (ultrasonic power (A), frequency (B), time (C), initial temperature (D) and pH (E)). The results showed that the oil recovery efficiency was mainly affected by the ultrasonic power and hydrophilicity of sludge (the highest 92% of oil recovery rate was achieved with the ultrasonic power of 240 W and hydrophilic sludge). Moreover, the wettability, decreased average particle size and increased specific surface area of sludge were found after ultrasonic treatment. Besides, changes in the oil component, such as the decrease of asphaltenes along with an increase of saturates, were also further observed. Therefore, the findings in this study can provide technical support for the practical application of ultrasonic technology in different kinds of oily sludge treatment.

Occurrences and behaviors of naphthenic acids in a petroleum refinery wastewater treatment plant.

Naphthenic acids (NAs) are one class of compounds in wastewaters from petroleum industries that are known to cause toxic effects, and their removal from oilfield wastewater is an important challenge for remediation of large volumes of petrochemical effluents. The present study investigated occurrences and behaviors of total NAs and aromatic NAs in a refinery wastewater treatment plant, located in north China, which combined physicochemical and biological processes. Concentrations of total NAs were semiquantified to be 113-392 µg/L in wastewater from all the treatment units, and the percentages of aromatic NAs in total NAs was estimated to be 2.1-8.8%. The mass reduction for total NAs and aromatic NAs was 15±16% and 7.5±24% after the physicochemical treatment, respectively. Great mass reduction (total NAs: 65±11%, aromatic NAs: 86±5%) was observed in the biological treatment units, and antiestrogenic activities observed in wastewater from physicochemical treatment units disappeared in the effluent of the activated sludge system. The distributions of mass fractions of NAs demonstrated that biodegradation via activated sludge was the major mechanism for removing alicyclic NAs, aromatic NAs, and related toxicities in the plant, and the polycyclic NA congener classes were relatively recalcitrant to biodegradation, which is a complete contrast to the preferential adsorption of NAs with higher cyclicity (low Z value). Removal efficiencies of total NAs were 73±17% in summer, which were higher than those in winter (53±15%), and the seasonal variation was possibly due to the relatively high microbial biotransformation activities in the activated sludge system in summer (indexed by O3-NAs/NAs). The results of the investigations indicated that biotransformation of NA mixtures by the activated sludge system were largely affected by temperature, and employing an efficient adsorbent together with biodegradation processes would help cost-effectively remove NAs in petroleum effluents.

Effects of osteoarthritis on load transfer after cemented total shoulder arthroplasty.

BACKGROUND: Total shoulder arthroplasty is commonly performed to treat glenohumeral osteoarthritis (OA); however, little is understood of the mechanics of the reconstructed OA shoulder. We sought to establish the effects of OA-induced changes in bone density and retroversion angle on load transfer and stress distribution in the bone-implant system of the scapula. METHODS: We developed finite element models of reconstructed healthy and OA scapulas with a virtually implanted glenoid prosthesis design. For the OA scapula, models with uncorrected and corrected retroversion were created. Loads were applied at the center or posteriorly on the glenoid surface. RESULTS: Our results suggest that with reconstruction of the corrected glenoid with a contemporary implant, cement stresses increase and the load transfer pattern changes with eccentric loads. The load transfer and local stresses in the bone-implant system in the retroverted glenoid are less sensitive to changes in loading location. Furthermore, the load transfer in the OA glenoid is less sensitive to the effect of peg proximity to the cortical shell than in the healthy glenoid. CONCLUSION: We provided evidence of how load sharing is altered among healthy, corrected OA, and retroverted OA glenoids. We demonstrated that correction of retroversion in OA glenoids may actually increase the risk for stress shielding and cement failure compared with retroverted glenoids, and OA patients can accommodate shorter pegs because of the higher glenoid bone stiffness in the OA glenoid.

Nonconforming glenoid increases posterior glenohumeral translation after a total shoulder replacement.

BACKGROUND: The major complication in nonconforming total shoulder replacement (TSR) is glenoid loosening and is attributed to posteriorly directed humeral head translations. Whether the posterior translations observed clinically are induced by radial mismatch is unclear. The objective of our study was to explain the posterior glenohumeral translations observed clinically after TSR by determining the glenohumeral translation and contact force as a function of radial mismatch. We hypothesized that the posterior direction of glenohumeral translation during scaption would be related to the radial mismatch and that the joint contact force would increase as the radial mismatch increased. METHODS: A 6-degrees-of-freedom computational model of the glenohumeral joint was developed. We determined the muscle forces, joint contact force, and glenohumeral translation for radial mismatches from 1 mm to 20 mm with the shoulder positioned from 20° to 60° of scaption. RESULTS: As the radial mismatch increased, the contact location of the humeral head moved posteriorly and inferiorly. The middle deltoid force decreased by 3%, while the supraspinatus and infraspinatus muscle forces increased by 9% and 11%, respectively. The joint contact force remained relatively constant. CONCLUSIONS: Increased posterior glenohumeral translations were observed with increased radial mismatch. Clinical observations of posterior translation may be attributed to the balancing forces of the middle deltoid, infraspinatus, and supraspinatus muscles. High radial mismatches may lead to eccentric posterior loading on the glenoid component, which could lead to implant loosening and failure.

Load transfer after cemented total shoulder arthroplasty.

BACKGROUND: Glenoid loosening is the primary reason for failure after a total shoulder arthroplasty (TSA), but the failure mechanism is not yet known. This study determined how the load transfer and stress distribution are affected by the introduction of a glenoid implant. METHODS: We developed a finite-element model of a scapula with and without a virtually implanted modern glenoid prosthesis design. Two load magnitudes were considered: normal and high. Loading locations were simulated at the center and at 4 eccentric positions on the glenoid. A metal-backed implant was also simulated to understand the effect of fixation stiffness. RESULTS: In the intact glenoid, for both center and eccentric loading, the majority of stress was distributed in the cancellous bone, whereas after a reconstruction, stresses in that region were lower. Metal-backed implants further decreased the joint load carried by the bone. Stresses in the cement layer increased during eccentric and high-magnitude loading. CONCLUSION: This study provided a basic understanding of the load-sharing phenomenon after a TSA that could explain glenoid loosening failure. Our results suggest that with reconstruction of the glenoid with a contemporary implant, the load transfer pattern is significantly altered, with eccentric and high-magnitude loads increasing stresses in the cement indicating potential for failure. The use of a metal-backed implant reduces the load carried by the bone, which may be detrimental to long-term TSA survival.

Effects of chitosan coatings on polypropylene mesh for implantation in a rat abdominal wall model.

Hernia repair and pelvic floor reconstruction are usually accompanied with the implantation of a surgical mesh, which frequently results in a foreign body response with associated complications. An ideal surgical mesh that allows force generation of muscle tissues without significant granulation tissue and/or fibrosis is of significant clinical interest. The objective of the present study was to evaluate the in vitro and in vivo responses of a chitosan coating on polypropylene mesh (Ch-PPM) in comparison with commercially available meshes. We found that application of a 0.5% (w/v) Ch-PPM elicited preferential attachment of myoblasts over fibroblast attachment in vitro. Therefore, we test the hypothesis that 0.5% Ch-PPM will encourage skeletal muscle tissue ingrowth and decrease fibrosis formation in vivo. We implanted 0.5% Ch-PPM, collagen-coated polypropylene mesh (Pelvitex™; C.R. Bard), and polypropylene (Avaulta Solo(®); C.R. Bard) alone using a rat abdominal defect model. Force generation capacity and inflammatory response of each mesh were evaluated 2, 4, and 12 weeks postimplantation. We found that chitosan coating is associated with the restoration of functional skeletal muscle with histomorphologic characteristics that resemble native muscle and an early macrophage phenotypic response that has previously been shown to lead to more functional outcomes.

Comparison of archaeal and bacterial community structures in heavily oil-contaminated and pristine soils.

Archaeal and bacterial community structures in heavily oil-contaminated and pristine soils were compared using denaturing gradient gel electrophoresis and 16S rRNA gene libraries. The results showed that archaeal diversity was more complex in the contaminated soil than in the uncontaminated control soil. Archaeal populations in the contaminated soil consisted mainly of Euryarchaeota, with abundant methanogen-like operational taxonomic units (OTUs) and OTUs related to the phylogenetically diverse group, candidate division I, corresponding to rice cluster V. In contrast, only halophilic archaea were found in the pristine soil. Bacterial community structures also differed significantly between the contaminated and pristine soils. More clones from the contaminated soil were related to known hydrocarbon-degrading bacteria, implying that microorganisms with the potential to degrade petroleum were well-established. These results provide further insights into the composition of microbial communities in oil-contaminated soils.

[Removal of humic substances using cerium-iron adsorbent].

A rare earth metal inorganic adsorbent, cerium-iron adsorbent (CFA), was developed, and its performance for fulvic acid (FA) removal was evaluated. Experimental results show that rare earth metal adsorbent had a relatively high adsorption capacity and good kinetic property for FA ion under the pH range of 3.0-6.5, then the adsorption capacity decreased with the increase of pH. FA seriously inhibited the removal of arsenate, suggesting that the adsorption sites for As(V) and FA were similar. Fourier transform infrared (FTIR) spectra of CFA before and after FA adsorption demonstrated that M-OH groups plays an important role for FA removal. The pH(icp) is 5.6 through the measure of Zeta potential.