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1.
Akush Ginekol (Sofiia) ; 55(6): 25-30, 2016.
Artigo em Búlgaro | MEDLINE | ID: mdl-29370503

RESUMO

In today's dynamic development of modern life, we can unfortunately see more and more often cases of malignant diseases during pregnancy. Therapy of these conditions in pregnant women is a challenge to the doctors, due to concerns for the mother's health, but also the possible risks for the foetus. An additional difficulty is the fact that there are no common algorithms for the treatment. Of great importance is the ges'tation period, because in its different parts, the risks vary in grade. It is believed that up to 10-12th ges.tation week chemotherapy should not be included. The optimal time for the last course is 35th gestation week or three weeks to the due date. The purpose of this review is to examine the benefits and risks of the treatment of malignant diseases during pregnancy for both the mother and the fetus.


Assuntos
Antineoplásicos/uso terapêutico , Complicações Neoplásicas na Gravidez/tratamento farmacológico , Antineoplásicos/efeitos adversos , Antineoplásicos/farmacocinética , Carboplatina/efeitos adversos , Carboplatina/farmacocinética , Carboplatina/uso terapêutico , Ciclofosfamida/efeitos adversos , Ciclofosfamida/farmacocinética , Ciclofosfamida/uso terapêutico , Doxorrubicina/efeitos adversos , Doxorrubicina/farmacocinética , Doxorrubicina/uso terapêutico , Tratamento Farmacológico/métodos , Epirubicina/efeitos adversos , Epirubicina/farmacocinética , Epirubicina/uso terapêutico , Feminino , Idade Gestacional , Humanos , Gravidez , Complicações Neoplásicas na Gravidez/diagnóstico , Trastuzumab/efeitos adversos , Trastuzumab/farmacocinética , Trastuzumab/uso terapêutico , Vimblastina/efeitos adversos , Vimblastina/farmacocinética , Vimblastina/uso terapêutico
2.
Probl Khig ; 7: 119-26, 1982.
Artigo em Búlgaro | MEDLINE | ID: mdl-7178064

RESUMO

Studies on surface waters were carried out for the presence of 2,4-D. The objects were selected from regions with intensive application of the herbicide. The studies were carried out by means of gas-liquid chromatography after derivatization of 2,4-D to methyl ester by diazomethane. The presence of 2,4-D in concentrations from 0,1 to 2,6 micrograms/dm3 was confirmed in an average of 68 per cent of the samples analyzed--rivers, dams, microdams and field water sources, with no data for seasonal or local oscillations. The residual quantities of 2,4-D in the surface water, confirmed in the present study, are 1000 and 100 resp. times less as compared with the literature data and the standards of the foreign sanitary legislations.


Assuntos
Ácido 2,4-Diclorofenoxiacético/análise , Poluentes Químicos da Água/análise , Poluentes da Água/análise , Água/análise , Bulgária , Cromatografia Gasosa , Concentração Máxima Permitida , Resíduos de Praguicidas/análise
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