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1.
Rev Neurol (Paris) ; 149(10): 547-53, 1993.
Artigo em Francês | MEDLINE | ID: mdl-8023069

RESUMO

We observed 40 patients aged from 15 to 40 years who suffered either a transient ischemic attack or an arterial ischemic stroke. All patients were clinically and physically examined, i.e. chest-X rays, electrocardiograms, biological tests and C.T. scan or magnetic resonance imaging that confirmed the diagnosis of ischemic cerebral infarction. Most patients underwent echocardiography and angiography. The time span between the onset of the ischemic event and angiography was recorded. A few of them had CSF analysis and determinations of antithrombin III, protein C and protein S. The etiology was confirmed in 15 patients (5 cardioembolic diseases, 7 vasculopathies, 3 coagulopathies). Twenty three had well-known vascular risk factors, but also an increase in serum fibrinogen concentration, which might have been associated with specific predisposing factors: oral contraceptives, patent foramen ovale, migraine, craniocervical trauma, acute alcohol intoxication and infectious diseases. No cause was found in 2 patients. We suggest a practical approach and highlight the value of angiography when performed early in the course of the illness to enhance the percentage of positive diagnosis. About 45 p. 100 of the patients followed-up (mean duration: 3 years) were unable to resume normal professional activity.


Assuntos
Isquemia Encefálica/etiologia , Infarto Cerebral/etiologia , Adolescente , Adulto , Isquemia Encefálica/diagnóstico , Doenças Cardiovasculares/complicações , Angiografia Cerebral , Infarto Cerebral/diagnóstico , Feminino , Seguimentos , Humanos , Masculino , Estudos Retrospectivos , Fatores de Risco , Fumar/efeitos adversos
2.
Rev Neurol (Paris) ; 148(6-7): 493-5, 1992.
Artigo em Francês | MEDLINE | ID: mdl-1448669

RESUMO

We report the results of a combined of chemotherapy with CDDP and 5 FU repeated every 3 weeks in sixteen men (age range 31-73 years) with brain metastases. CT was performed after 2, 4 and 6 cycles to assess efficiency. Response was considered complete when no lesion was found on the CT scan and partial when the lesion shrunk to least half its the total volume. After two cycles, the response rate was 8/16 (50%). Treatment toxicity was mild with only one case of severe but reversible myelotoxicity (grade III). CDDP and 5 FU combined chemotherapy can be a useful treatment for brain metastasis of lung carcinoma.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Encefálicas/tratamento farmacológico , Carcinoma Broncogênico/patologia , Neoplasias Pulmonares/patologia , Adulto , Idoso , Neoplasias Encefálicas/diagnóstico por imagem , Cisplatino/administração & dosagem , Fluoruracila/administração & dosagem , Humanos , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
3.
Bull Cancer ; 78(9): 831-7, 1991.
Artigo em Francês | MEDLINE | ID: mdl-1751834

RESUMO

Chemotherapy is not a common treatment for cerebral metastases. The authors report results of combination chemotherapy with cisplatin (CDDP) and fluorouracil (5-FU). Sixteen men (age range 31-73 years) with brain metastases were treated with CDDP 20 mg/m2/day in continuous infusion for 5 days (d 1-5) and 5-FU 1 g/m2/day in continuous infusion for 4 days (d 1-4), and the treatment schedule repeated every 3 weeks. A brain computerized tomography after 2, 4 and 6 cycles was performed to assess efficacy. It was considered that complete response was achieved if no lesion was found on the CT scan, and partial response if at least half of the total volume had decreased. After 2 cycles, the response rate was therefore 8/16 (50%). Treatment toxicity was very mild with only 1 case of severe but reversible myelotoxicity (grade III). It is concluded that chemotherapy combination with CDDP and 5-FU is a useful treatment for brain metastasis of lung carcinoma.


Assuntos
Neoplasias Encefálicas/tratamento farmacológico , Neoplasias Encefálicas/secundário , Cisplatino/uso terapêutico , Fluoruracila/uso terapêutico , Neoplasias Pulmonares/patologia , Adulto , Idoso , Neoplasias Encefálicas/diagnóstico por imagem , Cisplatino/administração & dosagem , Quimioterapia Combinada , Ecoencefalografia , Fluoruracila/administração & dosagem , Humanos , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
5.
Sem Hop ; 58(20): 1268-71, 1982 May 20.
Artigo em Francês | MEDLINE | ID: mdl-6285517

RESUMO

The authors discuss the case of a 15-year-old girl suffering from intra-cranial hypertension. Neuroradiological examinations do not reveal any obstruction in the cerebral spinal fluid circulation. The CSF cylologic examination was the first to give etiological indications, showing the existence of malignant cells which the cerebral biopsy later enabled us to classify as glioblastoma. This case affords an opportunity to recall the three stages of the diagnosis: first, intra-cranial hypertension; secondly, chronic meningitis; thirdly, cytological difficulties in the examination of CSF in patients having undergone neuro-radiological examinations.


Assuntos
Neoplasias Encefálicas/líquido cefalorraquidiano , Líquido Cefalorraquidiano/citologia , Pressão Intracraniana , Adolescente , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/fisiopatologia , Doença Crônica , Diagnóstico Diferencial , Feminino , Glioblastoma/líquido cefalorraquidiano , Humanos , Meningite/etiologia , Pseudotumor Cerebral/diagnóstico
6.
J Radiol ; 63(4): 273-7, 1982 Apr.
Artigo em Francês | MEDLINE | ID: mdl-7131390

RESUMO

We report a fourteen member family presenting with an anomaly of the seventh cervical vertebra. The symptoms associate pain and paresthesias, a C8-D1 syndrome or arterial manifestations. The radiologic lesions noticed are bilateral in twelve cases, either cervical ribs or apophysomegaly of the seventh vertebra's transverse process. There is no correlation between the severity of the clinical impairment and the importance of the radiologic image. We insist on the familial character rarely reported in the literature of an anomaly noticed in radiologic practice.


Assuntos
Síndrome da Costela Cervical/genética , Síndrome do Desfiladeiro Torácico/genética , Adulto , Idoso , Síndrome da Costela Cervical/diagnóstico por imagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia
7.
Sem Hop ; 58(11): 639-48, 1982 Mar 18.
Artigo em Francês | MEDLINE | ID: mdl-6278608

RESUMO

Practitioners should be familiar with the description of transient ischemic attacks (TIA) as 40% are followed more or less rapidly by a stroke. Analysis of the natural history of TIA shows that patients die twice as often from cardiac manifestations of atheroma than from cerebral lesions. This demonstrates the significance of diagnosis and treatment of risk factors. Patients are at increased risk of stroke during the six to twelve months following TIA. Anticoagulants and inhibitors of platelet aggregation seem to reduce this risk. Carotid surgery is indicated only for localized vascular lesions; in other cases surgery increases morbidity. Doppler examination is the best means of detecting cases which need emergency surgical treatment.


Assuntos
Ataque Isquêmico Transitório/terapia , Anticoagulantes/uso terapêutico , Arteriosclerose/complicações , Aspirina/uso terapêutico , Doenças das Artérias Carótidas/cirurgia , Revascularização Cerebral , Endarterectomia/efeitos adversos , Humanos , Ataque Isquêmico Transitório/diagnóstico , Ataque Isquêmico Transitório/etiologia , Agregação Plaquetária/efeitos dos fármacos , Risco , Ultrassonografia
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