Assuntos
Adenolinfoma/patologia , Linfoma de Células T Periférico/patologia , Adenolinfoma/genética , Adenolinfoma/metabolismo , Idoso , Antígenos CD/análise , Antígenos CD20/análise , Complexo CD3/análise , Antígenos CD79 , Rearranjo Gênico da Cadeia gama dos Receptores de Antígenos dos Linfócitos T/genética , Humanos , Imuno-Histoquímica , Antígeno Ki-1/análise , Leucossialina , Excisão de Linfonodo , Linfonodos/patologia , Linfoma de Células T Periférico/genética , Linfoma de Células T Periférico/metabolismo , Masculino , Reação em Cadeia da Polimerase , Receptores de Antígenos de Linfócitos B/análise , Sialoglicoproteínas/análiseAssuntos
Transfusão de Sangue , Transplante de Medula Óssea/métodos , Sistema ABO de Grupos Sanguíneos/imunologia , Doença Aguda , Anemia Aplástica/cirurgia , Animais , Células Sanguíneas/transplante , Purging da Medula Óssea/efeitos adversos , Transplante de Medula Óssea/efeitos adversos , Terapia Combinada , Infecções por Citomegalovirus/etiologia , Infecções por Citomegalovirus/prevenção & controle , Cães , Rejeição de Enxerto , Histocompatibilidade , Antígenos de Histocompatibilidade Classe I/imunologia , Humanos , Leucemia/imunologia , Leucemia/cirurgia , Leucemia/terapia , Pancitopenia/etiologia , Pancitopenia/terapia , Cuidados Pós-Operatórios , Cuidados Pré-Operatórios , Fatores de Risco , Reação TransfusionalRESUMO
Antiglobulin test (AT) and Dixon tests were performed in 100 patients with CLL. Thirty-five of them had Rai stages 0 or 1, 19 stage 2, 13 stage 3, and 33 stage 4. Twelve patients showed red blood cells autoantibodies (RBCAb) positivity; positivity at Dixon test (direct, indirect, or both) was observed in 74%. The presence of autoantibodies against erythrocytes and platelets did not influence survival curves, but anemia and thrombocytopenia are considered risk factors, independently of the presence of an autoimmune disorder. Nine RBCAb positive patients with positive Dixon test had the worst survival curves, 5 of these were anemic and 1 thrombocytopenic and anemic.
Assuntos
Autoanticorpos/análise , Plaquetas/imunologia , Eritrócitos/imunologia , Leucemia Linfocítica Crônica de Células B/sangue , Idoso , Idoso de 80 Anos ou mais , Antígenos de Grupos Sanguíneos/imunologia , Feminino , Humanos , Leucemia Linfocítica Crônica de Células B/mortalidade , Masculino , Prognóstico , Análise de SobrevidaAssuntos
Soropositividade para HIV/complicações , Doença de Hodgkin/complicações , Síndrome da Imunodeficiência Adquirida/complicações , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Doença de Hodgkin/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Antiglobulin Test (AT), and Dixon Tests (DT) have been studied in 100 patients with CLL. Thirty-five patients were Rai stage 0 and I, 19 patients stage 2, 13 patients stage 3 and 33 patients stage 4. Twelve patients showed a Red Blood Cells Autoantibodies (RBCAb) positivity; a positivity (direct, indirect, or both) of DT was present in 74% of patients. The presence of autoantibodies against erythrocytes and platelets did not influence survival curves, but anemia and thrombocytopenia are risk factors for survival, independently of the presence of an autoimmune disorder. Nine patients RBCAb positive and DT positive showed the worst survival curve, five out of these were anemic and one thrombocytopenic and anemic.
Assuntos
Autoanticorpos/análise , Antígenos de Grupos Sanguíneos/imunologia , Plaquetas/imunologia , Leucemia Linfocítica Crônica de Células B/sangue , Idoso , Anemia Hemolítica Autoimune/sangue , Anemia Hemolítica Autoimune/etiologia , Teste de Coombs , Feminino , Humanos , Imunoglobulina G/análise , Leucemia Linfocítica Crônica de Células B/complicações , Masculino , Pessoa de Meia-Idade , Prognóstico , Trombocitopenia/sangue , Trombocitopenia/etiologiaRESUMO
A longitudinal electroencephalographic study of 100 patients suffering from acute leukaemia is reported. An high incidence of EEG abnormalities indicates the central nervous system involvement with no clinical manifestations. The patients have been divided in two groups: A) with normal EEG and B) with pathological (cerebro-meningeal localisation) but many causes (metabolic, toxic or microcirculatory disturbances) can produce the abnormalities. Moreover therapy may cause CNS disturbances with EEG evidence. The most damaging seems to be the simultaneous association of radiation therapy and methotrexate.
Assuntos
Neoplasias Encefálicas/diagnóstico , Eletroencefalografia/métodos , Leucemia/diagnóstico , Neoplasias Meníngeas/diagnóstico , Doença Aguda , Adolescente , Adulto , Idoso , Antineoplásicos/uso terapêutico , Criança , Quimioterapia Combinada , Potenciais Evocados/efeitos dos fármacos , Feminino , Humanos , Leucemia/tratamento farmacológico , Masculino , Pessoa de Meia-IdadeAssuntos
Ciclofosfamida/uso terapêutico , Linfoma/tratamento farmacológico , Prednisona/uso terapêutico , Procarbazina/uso terapêutico , Vimblastina/uso terapêutico , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
In a groups of 254 patients treated for Hodgkin's disease with a follow up period of minimum 2 years, 3 cases of acute non lymphoid leukaemia (ANLL) were observed: erythroleukaemia, myelomonocytic and myeloblastic leukaemia, respectively. The crude incidence of leukaemia in all patients was 0.0128 and patient year risk was estimated to be 0.003652. All 3 patients had received radiation therapy and chemotherapy. In all cases of haemopoietic dysplasia preceded ANLL. Bone marrow chromosome investigations showed an abnormal karyotype in all patients: chromosomal changes were present in 100% of cells and revealed a non-random distribution, the most frequent involvement being clustered to chromosomes nos 11, 17 and 21. Hypodiploidy was prevalent and multiple structural rearrangements, such as markers, rings and minutes, were present in a high percentage of cells. Other changes involved chromosomes nos 5, 7 and 14. Our results are compared with other previously reported cases and possible pathogenetic implications are discussed.