[The use of enzymes in treating patients with malignant lymphoma with a large tumor mass]. / Primenenie énzimov v lechenii bol'nykh zlokachestvennoi limfomoi s bol'shoi massoi opukholi.

Systemic enzymes (wobenzime and wobe-mugos) were approved, that had been prescribed as part of polychemotherapy to 24 patients with malignant lymphomas, who presented with large masses of lymphatic nodes poorly resorbable against the background of polychemotherapy and who were assigned for a high-total dose irradiation, which fact would undoubtedly entail sclerosing of adjacent intact tissues. The use of the enzymes made for the optimum realization of the polychemotherapy effect and permitted avoiding a good many of undesirable side events and complication thereof. The above systemic enzymes are well tolerated by patients; they induce no significant changes in the cellular composition or in blood biochemical indices.

[The use of propes in the combined treatment of malignant lymphomas]. / Primenenie propesa v kompleksnom lechenii zlokachestvennykh limfom.

Results are submitted of use of propes during different phases of treatment in 36 patients with malignant lymphomas. The above drug is associated with no complications or side effects, inhibits the development of the tumor process. The employment of propes permits enhancing both natural resistance of the organism and its killer activity. It is an effective aid to cytostatic therapy as a way for prophylaxis of hypoplasia of haemopoiesis which can be successfully used in other malignant tumors.

[Familial cases of lymphogranulomatosis]. / Semeinye sluchai limfogranulematoza.

Among patients with Hodgkin's disease 30 cases of the family disease were revealed during 1972-1988. The occurrence of family pairs of patients with Hodgkin's disease suggests a heritable anomaly or inheritance of a gene predisposing for this disease. In cases of contacts with second degree relatives and children from a single family, one cannot exclude a role of environmental factors and a concurrent transfer of the infectious factor. However, cases of family Hodgkin's disease might be due to a pure coincidence.

[A nontraditional variant for the irradiation of locally disseminated forms of lymphogranulomatosis]. / Netraditsionnnyi variant oblucheniia mestnorasprostranennykh form limfogranulematoza.

The authors describe immediate results of treatment of 29 patients with lymphogranulomatosis characterized by location above the diaphragm and large volume of tumour masses. Treatment included irradiation against the background of synchronization of cell cycles of the tumour cells and use of metothrexate and folic acid that allowed to reduce early and remote complications of radiation therapy due to reduction of the total radiation doses.

[Indirect endolymphatic chemotherapy of patients with lymphoma]. / Nepriamaia éndolimfaticheskaia khimioterapiia bol'nykh limfomami.

Treated were 103 patients with malignant lymphomas (lymphogranulomatosis--87; non-Hodgkin lymphomas--16 patients). The treatment was complex including chemotherapy by means of endolymphatic administration of cyclophosphane, prospidin, methotrexate). The technique may be widely used and may be associated with other treatment methods. The efficacy of the method is substantiated and emphasized.