Morphological changes in the brain of mice with systemic candidiasis treated with composition of amphotericin B and oxidized dextran.

We observed morphological manifestation of encephalitis 3, 7, 10 and 28 days after intravenous infection of adult male CBA mice with Candida albicans. Compounds were administered intraperitoneally every other day starting from the next day postinfection. Untreated animals (100%) died over the period between days 18 and 20 postinfection; 60% animals receiving oxidized dextran alone survived by day 28 of observation. All animals treated with amphotericin B and composition of amphotericin B and oxidized dextran survived. On day 3 postinfection, the count of macrophage infiltrates and granulomas in the cerebral interstitium of mice treated with amphotericin B was equal to that in untreated mice, but was sufficiently lower in animals treated with the composition or oxidized dextran alone. On day 10, this index was similar in all groups and was approximately 5 times lower than in untreated animals on day 3. On day 28, macrophage infiltrates and granulomas were absent in the brain of all treated mice. These data suggest that oxidized dextran produced a therapeutic effect, which manifested earlier than the effect of amphotericin B and potentiated its effect, probably due to its competition with Candida albicans for mannose receptors on the brain-blood barrier endothelium.

[Alternative endobiliary operations for choledocholithiasis and papilla of Vater stenosis].

The immediate results of endoscopic papillosphincterotomy (EPST) (n=754) and endobiliary balloon dilatation (n=120) were comparatively analyzed. Survey included patients with choledocholithiasis and papilla Vateri stenosis. The use of balloon dilatation and EPST was defined by the size and amount of gallstones. Balloon dilatation was preferable when there less then 3 concrements. "Critical" diameter of the gallstone, which permitted the use of endobiliary dilatation, was 9 mm. In cases of the papilla Vateri stenosis balloon dilatation also demonstrated better results then EPST: 93,5+/-3,6% and 79,4+/-2,8% of satisfactory results, respectively).

[Percutaneous transhepatic papillosphincterotomy and roentgen endobiliary dilatation in cholelithiasis complicated by mechanical jaundice].

A comparative analysis of treatment was made in two groups of patients with cholelithiasis complicated by mechanical jaundice who for certain causes could not be subjected to endoscopic retrograde endobiliary interventions. Percutaneous transhepatic antegrade papillosphincterotomy and endobiliary balloon dilatation extend the possibilities of rendering medical care to this category of patients. The main indications to antegrade interventions are: impossible retrograde cannulation of the major duodenal papilla, impossible endoscopic control of the position of the papillotome in the papilla zone.

[Several indices of immunity in the pre- and postoperative periods of patients with brain neoplasms]. / Nekotorye polazateli immuniteta v do- i posleoperatsionnom periode u bol'nykh s opukholiami golovnogo mozga.

Surgical trauma of the brain in neurooncological patients is accompanied by acute blood loss, results in a significant suppression of the resistance of the body, thus favouring the development of endogenous infection. The mobilization of the body resistance forces falls behind the growth of the number of pathogens. An active tactics is mandatory for the restoration of the suppressed immune systems by way of specific and nonspecific immunity stimulation.