RESUMO
Pseudomyxoma peritonei is an appendiceal tumor with distinct clinical and pathologic features. It frequently presents a problem in diagnosis and management. We report a case of pseudomyxoma peritonei, which initially appeared with intestinal obstruction. This is a rare initial manifestation in patients who have not had multiple surgical procedures. We review the literature and discuss the unique clinical features and misconceptions surrounding pseudomyxoma peritonei.
Assuntos
Obstrução Intestinal/diagnóstico , Intestino Delgado/patologia , Neoplasias Peritoneais/diagnóstico , Pseudomixoma Peritoneal/diagnóstico , Adenocarcinoma/patologia , Neoplasias do Apêndice/complicações , Neoplasias do Apêndice/diagnóstico , Neoplasias do Apêndice/cirurgia , Seguimentos , Humanos , Neoplasias Intestinais/complicações , Neoplasias Intestinais/diagnóstico , Neoplasias Intestinais/cirurgia , Obstrução Intestinal/etiologia , Obstrução Intestinal/cirurgia , Intestino Delgado/cirurgia , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/patologia , Neoplasias Peritoneais/complicações , Neoplasias Peritoneais/cirurgia , Pseudomixoma Peritoneal/complicações , Pseudomixoma Peritoneal/patologia , Pseudomixoma Peritoneal/cirurgiaRESUMO
We considered the role of two neutrophil chemotactic agents (interleukin-8 and leukotriene B4) and of myeloperoxidase (a neutrophil-associated enzyme) in the pathologic condition of Crohn's disease (CD). Serial biopsy samples were taken at different sites in the colon, washed in 0.02 M phosphate-saline buffer, homogenized, and then sonicated. Interleukin-8 levels were significantly increased throughout the colonic mucosa (> 300 pg/mg protein) in patients with CD compared with control groups (< 40 pg/mg protein) (p < or = 0.01). A two- to six-fold increase in leukotriene B4 was also found in CD, whereas mucosal levels of myeloperoxidase were unchanged compared with control subjects. This study demonstrates that interleukin-8 and leukotriene B4 may have an immunologic role in the pathologic condition of CD.
Assuntos
Colo/química , Doença de Crohn/metabolismo , Interleucina-8/análise , Mucosa Intestinal/química , Adulto , Idoso , Cromatografia Líquida de Alta Pressão , Humanos , Leucotrieno B4/análise , Pessoa de Meia-Idade , Peroxidase/análise , RadioimunoensaioRESUMO
In this study, mediators of inflammation were characterized in colonic and terminal ileum mucosa from subjects with ulcerative colitis. We considered the role of two different chemotactic factors (interleukin-8 and leukotriene B4) and of myeloperoxidase in the pathology of inflammatory bowel disease. Serial biopsy specimens were taken at different sites, washed in 0.02 M phosphate/saline buffer, homogenized, and then sonically disrupted. In both the proximal and distal regions of the colonic mucosa of ulcerative colitis patients, there was a more than 10-fold increase in interleukin-8 levels over that in control subjects (> 300 pg/mg protein vs. 30 pg/mg protein in controls, p < or = 0.01). However, terminal ileum levels of interleukin-8 were the same in ulcerative colitis and control groups (150 pg/mg protein). There was also a 3- to 5-fold increase in leukotriene B4 levels and a several-fold increase in myeloperoxidase levels throughout the colonic mucosa in patients with ulcerative colitis. This study demonstrates that 1) interleukin-8 may have an immunoregulatory role in the pathogenesis of inflammatory bowel disease, and 2) interleukin-8, myeloperoxidase, and leukotriene B4 may be useful markers for the biochemical identification of inflammatory bowel disease.
Assuntos
Colite Ulcerativa/diagnóstico , Colo/metabolismo , Interleucina-8/imunologia , Mucosa Intestinal/metabolismo , Leucotrieno B4/imunologia , Neutrófilos/imunologia , Peroxidase/metabolismo , Adulto , Idoso , Biomarcadores/análise , Catalase/metabolismo , Colite Ulcerativa/imunologia , Humanos , Íleo/metabolismo , Interleucina-8/análise , Leucotrieno B4/análise , Pessoa de Meia-Idade , Peroxidase/fisiologia , RadioimunoensaioRESUMO
A 31-yr-old woman presenting with abdominal complaints and fever was found to have linitis plastica on upper gastrointestinal series. Endoscopic studies confirmed these findings; however, pathology revealed the diagnosis to be Kaposi's sarcoma. We believe this to be the first case report of linitis plastica presenting as Kaposi's sarcoma.