Deciphering the Functional Long Non-Coding RNAs Derived from MicroRNA Loci.

Albeit the majority of eukaryotic genomes can be pervasively transcribed to a diverse population of lncRNAs and various subtypes of lncRNA are discovered. However, the genome-wide study of miRNA-derived lncRNAs is still lacking. Here, it is reported that over 800 miRNA gene-originated lncRNAs (molncRNAs) are generated from miRNA loci. One of them, molnc-301b from miR-301b and miR-130b, functions as an "RNA decoy" to facilitate dissociation of the chromatin remodeling protein SMARCA5 from chromatin and thereby sequester transcription and mRNA translation. Specifically, molnc-301b attenuates erythropoiesis by mitigating the transcription of erythropoietic and translation-associated genes, such as GATA1 and FOS. In addition, a useful and powerful CRISPR screen platform to characterize the biological functions of molncRNAs at large-scale and single-cell levels is established and 29 functional molncRNAs in hematopoietic cells are identified. Collectively, the focus is on miRNA-derived lncRNAs, deciphering their landscape during normal hematopoiesis, and comprehensively evaluating their potential roles.

Construction of hierarchical sea urchin-like manganese substituted nickel cobaltite@tricobalt tetraoxide core-shell microspheres on nickel foam as binder-free electrodes for high performance supercapacitors.

Construction of binder-free electrodes with hierarchical core-shell nanostructures is considered to be an effective route to promote the electrochemical performance of supercapacitors. In this work, the porous Ni0.5Mn0.5Co2O4 nanoflowers anchored on nickel foam are utilized as framework for further growing Co3O4 nanowires, resulting in the hierarchical sea urchin-like Ni0.5Mn0.5Co2O4@Co3O4 core-shell microspheres on nickel foam. Owing to the advantages brought by unique porous architecture and synergistic effect of the multi-component composites, the as-prepared electrode exhibits a high specific capacitance (931 F/g at 1 A/g), excellent rate performance (77% capacitance retention at 20 A/g) and outstanding cycle stability (92% retention over 5000 cycles at 5 A/g). Additionally, the assembled Ni0.5Mn0.5Co2O4@Co3O4//AC (activated carbon) asymmetric supercapacitor achieves a high energy density (50 Wh/kg at 750 W/kg) and long durability (88% retention after 5000 cycles).