RESUMO
Porphyran (P) was extracted from red algae Porphyra by boiling water. A novel polysaccharide-iron complex (LPPC) was prepared under the alkaline condition by adding a ferric chloride solution to the low molecular weight porphyran (LP) solution. Physicochemical properties and inhibition effect on iron deficiency anemia of this complex were studied. The content of iron(III) in the complex is 21.57% determined with iodometry. The results indicate that LPPC was product required. The complex can increase red blood cell count (RBC), hemoglobin (Hb), Serum iron (SI), spleen index, spleen mass and mass of mice with iron deficiency anemia (IDA). Although the structure and deeper mechanisms on hemolytic anemia of LPPC should be further studied, LPPC is hoped to be developed as a late-model iron supplement which has a synergism on anemia.
Assuntos
Anemia Ferropriva/tratamento farmacológico , Química Farmacêutica/métodos , Físico-Química/métodos , Ferro/química , Polissacarídeos/química , Anemia Ferropriva/metabolismo , Animais , Varredura Diferencial de Calorimetria/métodos , Cloretos/química , Suplementos Nutricionais , Desenho de Fármacos , Eritrócitos/efeitos dos fármacos , Compostos Férricos/química , Hemoglobinas/metabolismo , Humanos , Ferro/sangue , Ferro/farmacologia , Camundongos , Porfirinas/química , Baço/metabolismo , TemperaturaRESUMO
The title mononuclear nickel(II) complex, [Ni(C(9)H(9)ClNO(2))(2)]·H(2)O, was obtained by the reaction of 5-chloro-salicyl-aldehyde, 2-amino-ethanol and nickel nitrate in methanol. The Ni atom is six-coordinated by two phenolate O, two imine N and two hy-droxy O atoms from two crystallographically different Schiff base ligands, forming an octa-hedral geometry. In the crystal, mol-ecules are linked through inter-molecular O-Hâ¯O and O-Hâ¯Cl hydrogen bonds.
RESUMO
In recent years, the studies on moxibustion for treatment of cancer are increasing day by day, with some advances. In the paper, clinical and experimental studies on traditional moxibustion for treatment of cancer and the mechanisms are reviewed, and some problems and shortcomings are put forward.