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1.
Surgery ; 167(4): 681-684, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31431292

RESUMO

Canada has been a leader in competency-based medical education for some years. Postgraduate training programs are typically 5 years in duration with opportunities to pursue 2-year subspecialty training after certification in a primary specialty. The introduction of competency-based models in Canada has progressed from a single orthopedic surgery training program at the University of Toronto through the adoption of competency-based medical education in 29 training programs at a single medical school, and the implementation across all 68 disciplines overseen by the Royal College of Physicians and Surgeons of Canada. This article outlines the introduction of competency-based medical education in postgraduate medical education in Canada.


Assuntos
Educação Baseada em Competências , Educação de Pós-Graduação em Medicina , Cirurgia Geral/educação , Internato e Residência , Canadá , Humanos , Procedimentos Ortopédicos/educação
2.
J Surg Educ ; 75(2): 344-350, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-28864267

RESUMO

INTRODUCTION: There is a recognized need to develop high-stakes technical skills assessments for decisions of certification and resident promotion. High-stakes examinations requires a rigorous approach in accruing validity evidence throughout the developmental process. One of the first steps in development is the creation of a blueprint which outlines the potential content of examination. The purpose of this validation study was to develop an examination blueprint for a Canadian General Surgery assessment of technical skill certifying examination. METHODS: A Delphi methodology was used to gain consensus amongst Canadian General Surgery program directors as to the content (tasks or procedures) that could be included in a certifying Canadian General Surgery examination. Consensus was defined a priori as a Cronbach's α ≥ 0.70. All procedures or tasks reaching a positive consensus (defined as ≥80% of program directors rated items as ≥4 on the 5-point Likert scale) were then included in the final examination blueprint. RESULTS: Two Delphi rounds were needed to reach consensus. Of the 17 General Surgery Program directors across the country, 14 (82.4%) and 10 (58.8%) program directors responded to the first and second round, respectively. A total of 59 items and procedures reached positive consensus and were included in the final examination blueprint. CONCLUSIONS: The present study has outlined the development of an examination blueprint for a General Surgery certifying examination using a consensus-based methodology. This validation study will serve as the foundational work from which simulated model will be developed, pilot tested and evaluated.


Assuntos
Certificação/normas , Competência Clínica , Educação de Pós-Graduação em Medicina/normas , Cirurgia Geral/educação , Internato e Residência/normas , Canadá , Consenso , Técnica Delphi , Feminino , Humanos , Masculino , Inquéritos e Questionários , Análise e Desempenho de Tarefas
3.
Surg Endosc ; 31(9): 3718-3727, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28451813

RESUMO

BACKGROUND: It is hypothesized that not all surgical trainees are able to reach technical competence despite ongoing practice. The objectives of the study were to assess a trainees' ability to reach technical competence by assessing learning patterns of the acquisition of surgical skills. Furthermore, it aims to determine whether individuals' learning patterns were consistent across a range of open and laparoscopic tasks of variable difficulty. METHODS: Sixty-five preclinical medical students participated in a training curriculum with standardized feedback over forty repetitions of the following laparoscopic and open technical tasks: peg transfer (PT), circle cutting (CC), intracorporeal knot tie (IKT), one-handed tie, and simulated laparotomy closure. Data mining techniques were used to analyze the prospectively collected data and stratify the students into four learning clusters. Performance was compared between groups, and learning curve characteristics unique to trainees who have difficulty reaching technical competence were quantified. RESULTS: Top performers (22-35%) and high performers (32-42%) reached proficiency in all tasks. Moderate performers (25-37%) reached proficiency for all open tasks but not all laparoscopic tasks. Low performers (8-15%) failed to reach proficiency in four of five tasks including all laparoscopic tasks (PT 7.8%; CC 9.4%; IKT 15.6%). Participants in lower performance clusters demonstrated sustained performance disadvantage across tasks, with widely variable learning curves and no evidence of progression towards a plateau phase. CONCLUSIONS: Most students reached proficiency across a range of surgical tasks, but low-performing trainees failed to reach competence in laparoscopic tasks. With increasing use of laparoscopy in surgical practice, screening potential candidates to identify the lowest performers may be beneficial.


Assuntos
Competência Clínica/normas , Educação Baseada em Competências , Laparoscopia/educação , Treinamento por Simulação , Estudantes de Medicina , Adulto , Canadá , Currículo , Retroalimentação , Feminino , Humanos , Laparoscopia/normas , Curva de Aprendizado , Masculino , Análise e Desempenho de Tarefas
4.
Am J Surg ; 214(2): 365-372, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27634423

RESUMO

BACKGROUND: Competency-based education necessitates assessments that determine whether trainees have acquired specific competencies. The evidence on the ability of internal raters (staff surgeons) to provide accurate assessments is mixed; however, this has not yet been directly explored in the operating room. This study's objective is to compare the ratings given by internal raters vs an expert external rater (independent to the training process) in the operating room. METHODS: Raters assessed general surgery residents during a laparoscopic cholecystectomy for their technical and nontechnical performance. RESULTS: Fifteen cases were observed. There was a moderately positive correlation (rs = .618, P = .014) for technical performance and a strong positive correlation (rs = .731, P = .002) for nontechnical performance. The internal raters were less stringent for technical (mean rank 3.33 vs 8.64, P = .007) and nontechnical (mean rank 3.83 vs 8.50, P = .01) performances. CONCLUSIONS: This study provides evidence to help operationalize competency-based assessments.


Assuntos
Colecistectomia Laparoscópica/normas , Competência Clínica , Educação Baseada em Competências , Cirurgia Geral/educação , Internato e Residência , Desempenho Profissional , Estudos de Viabilidade , Feminino , Humanos , Masculino , Salas Cirúrgicas
5.
Ann Surg ; 266(1): 1-7, 2017 07.
Artigo em Inglês | MEDLINE | ID: mdl-27753648

RESUMO

OBJECTIVES: The objectives of this study were to (1) create a technical and nontechnical performance standard for the laparoscopic cholecystectomy, (2) assess the classification accuracy and (3) credibility of these standards, (4) determine a trainees' ability to meet both standards concurrently, and (5) delineate factors that predict standard acquisition. BACKGROUND: Scores on performance assessments are difficult to interpret in the absence of established standards. METHODS: Trained raters observed General Surgery residents performing laparoscopic cholecystectomies using the Objective Structured Assessment of Technical Skill (OSATS) and the Objective Structured Assessment of Non-Technical Skills (OSANTS) instruments, while as also providing a global competent/noncompetent decision for each performance. The global decision was used to divide the trainees into 2 contrasting groups and the OSATS or OSANTS scores were graphed per group to determine the performance standard. Parametric statistics were used to determine classification accuracy and concurrent standard acquisition, receiver operator characteristic (ROC) curves were used to delineate predictive factors. RESULTS: Thirty-six trainees were observed 101 times. The technical standard was an OSATS of 21.04/35.00 and the nontechnical standard an OSANTS of 22.49/35.00. Applying these standards, competent/noncompetent trainees could be discriminated in 94% of technical and 95% of nontechnical performances (P < 0.001). A 21% discordance between technically and nontechnically competent trainees was identified (P < 0.001). ROC analysis demonstrated case experience and trainee level were both able to predict achieving the standards with an area under the curve (AUC) between 0.83 and 0.96 (P < 0.001). CONCLUSIONS: The present study presents defensible standards for technical and nontechnical performance. Such standards are imperative to implementing summative assessments into surgical training.


Assuntos
Colecistectomia Laparoscópica/educação , Colecistectomia Laparoscópica/normas , Competência Clínica , Internato e Residência , Adulto , Área Sob a Curva , Canadá , Feminino , Humanos , Masculino , Curva ROC , Reprodutibilidade dos Testes
6.
J Surg Educ ; 74(1): 100-107, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-27476793

RESUMO

BACKGROUND: Surgical programs strive to recruit trainees who will graduate as competent surgeons; however, selection processes vary between institutions. The purpose of the present study was to (1) solicit program directors' (PDs) opinions on the proportion of trainees who have difficulty achieving competence and (2) establish consensus on the desired attributes of general surgery (GS) candidates and the technical skills that would be most indicative of future performance. METHODS: Delphi consensus methodology was used. An open-ended questionnaire, followed by a closed-ended questionnaire, formulated as a 5-point Likert scale, was administered. A Cronbach α ≥ 0.8 with 80% of responses in agreement (4-agree and 5-strongly agree) determined the threshold for consensus. RESULTS: The first and second rounds were completed by 14 and 11, of a potential 17, GS PDs, respectively. PDs felt that 5% or less of trainees have difficulty reaching competence in clinical knowledge, 5% to 10% in decision-making, and 5% to 15% in technical skill by the time of completion of training. Consensus was excellent (α = 0.92). The top attributes for success in GS included work ethic and passion for surgery. Technical skills that felt to be most appropriate were open tasks (one-handed tie and subcuticular suture) and laparoscopic tasks (coordination, grasping, and cutting). CONCLUSION: PDs indicate that of the 3 domains, the largest proportion of trainees had difficulty reaching competence in technical skill. Consensus among PDs suggests that top personal attributes include work ethic and passion for surgery. Consensus of technical tasks for inclusion into selection was basic open and laparoscopic skills.


Assuntos
Educação de Pós-Graduação em Medicina/organização & administração , Cirurgia Geral/educação , Guias como Assunto/normas , Internato e Residência/normas , Corpo Clínico Hospitalar/normas , Seleção de Pessoal/normas , Canadá , Consenso , Técnica Delphi , Feminino , Humanos , Masculino
7.
Am J Surg ; 212(2): 354-60, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27018078

RESUMO

BACKGROUND: The objectives of this study were to assemble an international perspective on (1) current, and (2) ideal technical performance assessment methods, and (3) barriers to their adoption during: selection, in-training, and certification. METHODS: A questionnaire was distributed to international educational directorates. RESULTS: Eight of 10 jurisdictions responded. Currently, aptitude tests or simulated tasks are used during selection, observational rating scales during training and nothing is used at certification. Ideally, innate ability should be determined during selection, in-training evaluation reports, and global rating scales used during training, whereas global and procedure-specific rating scales used at the time of certification. Barriers include lack of predictive evidence for use in selection, financial limitations during training, and a combination with respect to certification. CONCLUSIONS: Identifying current and ideal evaluation methods will prove beneficial to ensure the best assessments of technical performance are chosen for each training time point.


Assuntos
Competência Clínica/normas , Avaliação Educacional/normas , Especialidades Cirúrgicas/educação , Especialidades Cirúrgicas/normas , Procedimentos Cirúrgicos Operatórios/educação , Procedimentos Cirúrgicos Operatórios/normas , Certificação/normas , Bolsas de Estudo/normas , Humanos , Internacionalidade , Internato e Residência/organização & administração , Inquéritos e Questionários
8.
J Surg Educ ; 73(3): 496-503, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26830927

RESUMO

PURPOSE: Similar to other countries, the practice of General Surgery in Canada has undergone significant evolution over the past 30 years without major changes to the training model. There is growing concern that current General Surgery residency training does not provide the skills required to practice the breadth of General Surgery in all Canadian communities and practice settings. PROCEDURE: Led by a national Task Force on the Future of General Surgery, this project aimed to develop recommendations on the optimal configuration of General Surgery training in Canada. A series of 4 evidence-based sub-studies and a national survey were launched to inform these recommendations. MAIN FINDINGS: Generalized findings from the multiple methods of the project speak to the complexity of the current practice of General Surgery: (1) General surgeons have very different practice patterns depending on the location of practice; (2) General Surgery training offers strong preparation for overall clinical competence; (3) Subspecialized training is a new reality for today's general surgeons; and (4) Generation of the report and recommendations for the future of General Surgery. A total of 4 key recommendations were developed to optimize General Surgery for the 21st century. CONCLUSIONS: This project demonstrated that a high variability of practice dependent on location contrasts with the principles of implementing the same objectives of training for all General Surgery graduates. The overall results of the project have prompted the Royal College to review the training requirements and consider a more "fit for purpose" training scheme, thus ensuring that General Surgery residency training programs would optimally prepare residents for a broad range of practice settings and locations across Canada.


Assuntos
Educação de Pós-Graduação em Medicina/tendências , Cirurgia Geral/educação , Cirurgia Geral/tendências , Canadá , Escolha da Profissão , Competência Clínica , Previsões , Humanos , Internato e Residência , Padrões de Prática Médica/estatística & dados numéricos , Área de Atuação Profissional , Inquéritos e Questionários
9.
Ann Surg ; 263(4): 673-91, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26079898

RESUMO

OBJECTIVE: To identify background characteristics and cognitive tests that may predict surgical trainees' future technical performance, and therefore be used to supplement existing surgical residency selection criteria. BACKGROUND: Assessment of technical skills is not commonly incorporated as part of the selection process for surgical trainees in North America. Emerging evidence, however, suggests that not all trainees are capable of reaching technical competence. Therefore, incorporating technical aptitude into selection processes may prove useful. METHODS: A systematic search was carried out of the MEDLINE, PsycINFO, and Embase online databases to identify all studies that assessed associations between surrogate markers of innate technical abilities in surgical trainees, and whether these abilities correlate with technical performance. The quality of each study was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation system. RESULTS: A total of 8035 records were identified. After screening by title, abstract, and full text, 52 studies were included. Very few surrogate markers were found to predict technical performance. Significant associations with technical performance were seen for 1 of 23 participant-reported surrogate markers, 2 of 25 visual spatial tests, and 2 of 19 dexterity tests. The assessment of trainee Basic Performance Resources predicted technical performance in 62% and 75% of participants. CONCLUSIONS: To date, no single test has been shown to reliably predict the technical performance of surgical trainees. Strategies that rely on assessing multiple innate abilities, their interaction, and their relationship with technical skill may ultimately be more likely to serve as reliable predictors of future surgical performance.


Assuntos
Testes de Aptidão , Aptidão , Competência Clínica , Cirurgia Geral/educação , Internato e Residência , Critérios de Admissão Escolar , Estudantes de Medicina/psicologia , Humanos , América do Norte
10.
Ann Surg ; 261(6): 1046-55, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25119118

RESUMO

OBJECTIVE: To systematically examine the literature describing the methods by which technical competence is assessed in surgical trainees. BACKGROUND: The last decade has witnessed an evolution away from time-based surgical education. In response, governing bodies worldwide have implemented competency-based education paradigms. The definition of competence, however, remains elusive, and the impact of these education initiatives in terms of assessment methods remains unclear. METHODS: A systematic review examining the methods by which technical competence is assessed was conducted by searching MEDLINE, EMBASE, PsychINFO, and the Cochrane database of systematic reviews. Abstracts of retrieved studies were reviewed and those meeting inclusion criteria were selected for full review. Data were retrieved in a systematic manner, the validity and reliability of the assessment methods was evaluated, and quality was assessed using the Grading of Recommendations Assessment, Development and Evaluation classification. RESULTS: Of the 6814 studies identified, 85 studies involving 2369 surgical residents were included in this review. The methods used to assess technical competence were categorized into 5 groups; Likert scales (37), benchmarks (31), binary outcomes (11), novel tools (4), and surrogate outcomes (2). Their validity and reliability were mostly previously established. The overall Grading of Recommendations Assessment, Development and Evaluation for randomized controlled trials was high and low for the observational studies. CONCLUSIONS: The definition of technical competence continues to be debated within the medical literature. The methods used to evaluate technical competence predominantly include instruments that were originally created to assess technical skill. Very few studies identify standard setting approaches that differentiate competent versus noncompetent performers; subsequently, this has been identified as an area with great research potential.


Assuntos
Competência Clínica/normas , Avaliação Educacional , Cirurgia Geral/normas , Internato e Residência/normas , Procedimentos Cirúrgicos Operatórios/normas , Educação Baseada em Competências/normas , Cirurgia Geral/educação , Humanos , Reprodutibilidade dos Testes , Procedimentos Cirúrgicos Operatórios/educação
13.
Can J Surg ; 55(1): 58-65, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22269304

RESUMO

This paper examines current issues concerning surgical fellowship training in Canada. Other than information from a few studies of fellowship training in North America, there are scant data on this subject in the literature. Little is known about the demographic characteristics of those who pursue fellowship training in Canada, what the experiences and expectations are of fellows and their supervisors with respect to the strengths and weaknesses of this level of training, or how this level of education fits in with Canadian undergraduate and postgraduate medical training. We summarize current knowledge about fellowship training in Canada as it pertains to demographic characteristics, finances, work hours, residency training, preparation for clinical and research work and satisfaction with training. Most information on surgical fellowship training comes from the United States. As such, we used information from American studies to supplement the Canadian data. Because a surgical fellowship experience in Canada may be different from that in the United States, we propose that Canadian surgical fellows and their supervisors should be surveyed to gain an understanding of such information. This knowledge could be used to improve surgical fellowship training in Canada.


Assuntos
Bolsas de Estudo , Cirurgia Geral/educação , Atitude do Pessoal de Saúde , Pesquisa Biomédica , Canadá , Comportamento de Escolha , Competência Clínica , Docentes de Medicina , Bolsas de Estudo/economia , Feminino , Médicos Graduados Estrangeiros , Humanos , Masculino , Mentores , Admissão e Escalonamento de Pessoal , Médicas , Salários e Benefícios , Especialização , Carga de Trabalho
14.
Vasc Endovascular Surg ; 45(3): 241-5, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21478245

RESUMO

The objective was to determine whether incision application of platelet-rich plasma (PRP) will decrease postoperative wound complications in vascular surgery patients. A prospective, randomized trial randomized 81 incisions in 51 patients who underwent femoral artery exposure for elective revascularization procedures or endovascular abdominal aneurysm repairs. Incidence of diabetes, chronic renal failure, prosthetic grafts, body mass index (BMI), and steroid use did not differ. Using the ASEPSIS wound classification system, we found no difference in incidence of wound infection. Wound complications occurred in 9 (23%) of 40 of PRP group and 9 (22%) of 41 of non-PRP. Severe wound complications developed in 5 (13%) PRP and 6 (5%) of non-PRP (P = NS). In multivariate analysis, there were no predictors for wound infection. Groin wound complications rates are common in this patient group. Platelet-rich plasma did not decrease the incidence of groin wound complications in our patients.


Assuntos
Artéria Femoral/cirurgia , Plasma Rico em Plaquetas , Infecção da Ferida Cirúrgica/etiologia , Procedimentos Cirúrgicos Vasculares/efeitos adversos , Técnicas de Fechamento de Ferimentos , Cicatrização , Idoso , Virilha/cirurgia , Humanos , Ontário , Estudos Prospectivos , Medição de Risco , Fatores de Risco , Índice de Gravidade de Doença , Infecção da Ferida Cirúrgica/prevenção & controle , Fatores de Tempo , Resultado do Tratamento
15.
Can J Surg ; 54(2): 95-100, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21251417

RESUMO

BACKGROUND: Surgeons and residents are at increased risk of exposure to blood-borne pathogens owing to percutaneous injury (PI) and contamination. One method known to reduce risk is double-gloving (DG) during surgery. METHODS: All surgeons and residents affiliated with the University of Western Ontario (UWO) and McMaster University in 2005 were asked to participate in a Web-based survey. The survey asked respondents their specialty, the number of operations they participated in per week, their age and sex, the proportion of surgeries in which they double-gloved (DG in ≥75% surgeries was considered to be routine), and the average number of PIs they sustained per year and whether or not they reported them to an employee health service. RESULTS: In total, 155 of 331 (47%) eligible surgeons and residents responded; response rates for UWO and McMaster surgeons were 50% and 39%, respectively, and for UWO and McMaster residents, they were 52% and 47%, respectively. A total of 43% of surgeons and residents reported routine DG; 50% from McMaster and 36% from UWO. Using logistic regression to simultaneously adjust for participant characteristics, we confirmed that DG was more frequent at McMaster than at UWO, with an odds ratio of 3.32 (95% confidence interval 1.35-8.17). Surgeons and residents reported an average of 3.3 surgical PIs per year (2.2 among McMaster participants and 4.5 among UWO participants). Of the 77% who reported at least 1 injury/year, 67% stated that they had not reported it to an employee health service. CONCLUSION: Percutaneous injuries occur frequently during surgery, yet routine DG, an effective means of reducing risk, was carried out by less than half of the surgeons and residents participating in this study. This highlights the need for a more concerted and broad-based approach to increase the use of a measure that is effective, inexpensive and easily carried out.


Assuntos
Cirurgia Geral , Luvas Cirúrgicas , Ferimentos Penetrantes Produzidos por Agulha/prevenção & controle , Padrões de Prática Médica/estatística & dados numéricos , Adulto , Cirurgia Geral/educação , Hospitais de Ensino , Humanos , Internato e Residência , Modelos Logísticos , Pessoa de Meia-Idade , Ontário , Adulto Jovem
16.
J Addict Med ; 4(1): 20-6, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20485532

RESUMO

OBJECTIVES: Despite high rates of hepatitis C virus (HCV) infection, relatively few current or former injection drug users receive evaluation and treatment for HCV. Here, we demonstrate the feasibility and effectiveness of integrating HCV care and methadone maintenance treatment (MMT). We hypothesized that colocation of these services would result in improved access to and utilization of HCV care. METHODS: In this retrospective observational study, all patient charts from a single MMT clinic were reviewed 2 years after HCV care and MMT were integrated. Information obtained included screening for and counseling about HCV infection status, on-site HCV treatment and outcomes, and demographic and substance abuse data. RESULTS: Two hundred ninety-one patient charts were reviewed. Two hundred eighty-one (99%) patients were screened for HCV antibody (HCV-Ab), and 188 (65%) were positive. Forty-nine (17%) patients were HIV/HCV coinfected. Ninety-eight percent of the HCV-Ab-positive patients received HCV counseling. Hundred fifty-nine (85%) of the HCV-Ab-positive patients were eligible to receive further evaluation and treatment for HCV on site, and 125 (78%) accepted. Hundred eighteen (94%) patients were tested for chronic HCV, and 83 were determined to have chronic HCV. Twenty-five patients received liver biopsy; low-stage disease was found in 7 patients. Twenty-one patients initiated HCV treatment. Sustained viral response was achieved in 8 patients. Seventeen patients had contraindications to HCV treatment. Further workup was prevented or delayed in 45 patients for various reasons, most commonly due to personal choice (29 patients). CONCLUSIONS: This study demonstrates that current and former injection drug users can be engaged successfully in evaluation and treatment of HCV infection when these services are collocated with MMT.

17.
Am J Physiol Gastrointest Liver Physiol ; 296(1): G9-G14, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19114681

RESUMO

Heme oxygenase (HO) represents the rate-limiting enzyme in the degradation of heme into carbon monoxide (CO), iron, and biliverdin. Recent evidence suggests that several of the beneficial properties of HO, may be linked to CO. The objectives of this study were to determine if low-dose inhaled CO reduces remote intestinal leukocyte recruitment, proinflammatory cytokine expression, and oxidative stress elicited by hindlimb ischemia-reperfusion (I/R). Male mice underwent 1 h of hindlimb ischemia, followed by 3 h of reperfusion. Throughout reperfusion, mice were exposed to AIR or AIR + CO (250 ppm). Following reperfusion, the distal ileum was exteriorized to assess the intestinal inflammatory response by quantifying leukocyte rolling and adhesion in submucosal postcapillary venules with the use of intravital microscopy. Ileum samples were also analyzed for proinflammatory cytokine expression [tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta] and malondialdehyde (MDA) with the use of enzyme-linked immunosorbent assay and thiobarbituric acid reactive substances assays, respectively. I/R + AIR led to a significant decrease in leukocyte rolling velocity and a sevenfold increase in leukocyte adhesion. This was also accompanied by a significant 1.3-fold increase in ileum MDA and 2.3-fold increase in TNF-alpha expression. Treatment with AIR + CO led to a significant reduction in leukocyte recruitment and TNF-alpha expression elicited by I/R; however, MDA levels remained unchanged. Our data suggest that low-dose inhaled CO selectively attenuates the remote intestinal inflammatory response elicited by hindlimb I/R, yet does not provide protection against intestinal lipid peroxidation. CO may represent a novel anti-inflammatory therapeutic treatment to target remote organs following acute trauma and/or I/R injury.


Assuntos
Anti-Inflamatórios/administração & dosagem , Monóxido de Carbono/administração & dosagem , Fármacos Gastrointestinais/administração & dosagem , Ileíte/prevenção & controle , Músculo Esquelético/irrigação sanguínea , Traumatismo por Reperfusão/tratamento farmacológico , Síndrome de Resposta Inflamatória Sistêmica/prevenção & controle , Administração por Inalação , Animais , Citocinas/metabolismo , Modelos Animais de Doenças , Membro Posterior , Ileíte/etiologia , Ileíte/imunologia , Interleucina-1beta/metabolismo , Migração e Rolagem de Leucócitos/efeitos dos fármacos , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Malondialdeído/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Microcirculação/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Traumatismo por Reperfusão/complicações , Traumatismo por Reperfusão/imunologia , Síndrome de Resposta Inflamatória Sistêmica/etiologia , Síndrome de Resposta Inflamatória Sistêmica/imunologia , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo , Fator de Necrose Tumoral alfa/metabolismo
19.
Ann Vasc Surg ; 21(5): 593-7, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17823041

RESUMO

Presently, only hydration and N-acetylcysteine have been shown to be effective in decreasing the incidence of radiographic contrast-induced nephropathy. We investigated the role of N-acetylcysteine and various hydration protocols in vascular surgery patients undergoing angiography. A single-center, randomized, placebo-controlled trial was conducted in patients with stable, preexisting renal dysfunction undergoing elective, outpatient angiography. Patients were randomized to outpatient oral hydration and N-acetylcysteine, inpatient hydration plus N-acetylcysteine, or our standard therapy of inpatient intravenous hydration alone. Two of twenty-eight (7%) patients who received outpatient oral hydration and N-acetylcysteine developed contrast-induced nephropathy, while two of 25 (8%) who recieved inpatient hydration plus N-acetylcysteine developed contrast-induced nephropathy and two of 25 (8%) who received standard therapy of inpatient intravenous hydration alone developed contrast-induced nephropathy. There was no statistical difference in incidence of contrast-induced nephropathy between the groups. No statistically significant independent risk factors were identified among the patients who developed contrast-induced nephropathy. N-Acetylcysteine did not confer additional benefit to patients treated with inpatient intravenous hydration. Outpatient oral hydration plus N-acetylcysteine was as effective at preventing contrast-induced nephropathy as inpatient therapies and avoided costly hospital admission.


Assuntos
Meios de Contraste/efeitos adversos , Nefropatias/prevenção & controle , Procedimentos Cirúrgicos Vasculares , Acetilcisteína/uso terapêutico , Assistência Ambulatorial , Aneurisma/diagnóstico por imagem , Angiografia , Meios de Contraste/administração & dosagem , Creatinina/sangue , Feminino , Hidratação , Seguimentos , Sequestradores de Radicais Livres/uso terapêutico , Hospitalização , Humanos , Nefropatias/induzido quimicamente , Falência Renal Crônica/complicações , Falência Renal Crônica/fisiopatologia , Masculino , Doenças Vasculares Periféricas/diagnóstico por imagem , Placebos , Estudos Prospectivos , Fatores de Risco
20.
Vasc Endovascular Surg ; 41(4): 301-9, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17704332

RESUMO

Short-term and midterm clinical outcomes after endovascular repair of abdominal aortic aneurysms (AAAs) have been well documented. Evaluation of longer term outcomes is now possible. Here we describe our initial 100 high-risk patients treated with endovascular aneurysm repair (EVAR), all with a minimum of 5 years of follow-up. A retrospective review of prospectively recorded data in a departmental database was undertaken for the first 100 consecutive EVAR patients with a minimum of 5 years (range, 60-105 months) of follow-up performed between December 1997 and June 2001. Information was obtained from surgical follow-up visits and family doctors' offices. Endovascular repair of AAA in high-risk patients can be achieved with acceptably low postoperative mortality and morbidity. Longer term results in this high-risk cohort suggest that EVAR is effective in preventing aneurysm-related deaths at 5 years and beyond. All late mortalities were due to patients' comorbid diseases.


Assuntos
Aneurisma da Aorta Abdominal/cirurgia , Implante de Prótese Vascular/métodos , Idoso , Idoso de 80 Anos ou mais , Aneurisma da Aorta Abdominal/mortalidade , Prótese Vascular , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Reoperação , Estudos Retrospectivos , Fatores de Risco , Estatísticas não Paramétricas , Stents , Resultado do Tratamento
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