Mental distress and subsequent use of psychotropic drugs among adolescents-a prospective register linkage study.

PURPOSE: To investigate the association between mental distress, other factors, and subsequent use of psychotropic drugs in adolescents aged 15-16 years. METHODS: This study is based on information retrieved from the Norwegian Youth Health Surveys (2000-2003) and linked to prescription data from the Norwegian Prescription Database (2004-2009). The study population included 11,620 adolescents aged 15-16 (87% response rate) years. Self-reported mental distress (Hopkins Symptom Checklist-10 score 1.85) was recorded along with health and lifestyle habits, education plans, and family economics. Incident psychotropic drug use (outcome measure) was defined ≥1 prescriptions of one of the following psychotropic drugs: anxiolytics, hypnotics, antidepressants, or phenothiazines registered in the Norwegian Prescription Database. RESULTS: Overall, 15.5% of the adolescents reported mental distress, 75% of them were girls. For both genders, incident psychotropic use was significantly higher among those reporting mental distresses at baseline, compared with the rest of the participants. The highest psychotropic drug use was observed among mentally distressed girls (27.7%). Mental distress was significantly associated with incident use of psychotropic drugs (odds ratio: 2.25, 95% confidence interval: 1.97-2.55). After adjustment for confounding factors and inclusion of potential mediating factors, the odds ratio attenuated to 1.59 (95% confidence interval: 1.35-1.86). CONCLUSIONS: The prevalence of mental distress among adolescents may have consequences for health promotion. Public health nurses in Norway, working in health centers and schools, have a responsibility to promote health and prevent health problems. They have the opportunity and a responsibility to identify vulnerable young people.

The association between smoking and subsequent repeated use of prescribed opioids among adolescents and young adults--a population-based cohort study.

BACKGROUND: The use of prescribed opioids for chronic non-cancer pain is increasing in many countries. It is, therefore, important to investigate predictors for repeated use of opioids in young non-cancer patients. OBJECTIVE: The aim of this study was to prospectively evaluate adolescent smoking and its association with repeated use of prescription opioids in adolescents/young adults without cancer. METHODS: The study population consisted of 11,809 15-16 year old participants (86% participation rate) in the Norwegian Youth Health Surveys carried out in 2000-2003. The exposure variable, self reported smoking status, was registered in the youth surveys along with potential confounders. Repeated use of opioids, defined as 4+ prescriptions recorded in the nationwide Norwegian Prescription Database during 2004-2008, was used as outcome measure. RESULTS: Among the participants included in our study, 161 had redeemed 4+ prescriptions for opioids. Daily adolescent smoking was associated with repeated use of opioids with an adjusted OR of 2.2 (95% CI 1.3-3.5). CONCLUSIONS: Daily smoking at 15-16 years of age was associated with increased risk of incident repeated use of prescribed opioids later in life. Our study suggests that smoking dependence in adolescents may predict longer lasting and/or higher levels of opioid use.

Disability pension is associated with the use of benzodiazepines 20 years later: a prospective study.

AIM: The Norwegian government states that actions are needed to stimulate working capacity in disability pension (DP) recipients with such a potential. Identification of factors that may impair rehabilitation efforts, such as information on the start of benzodiazepines in DP recipients, may be useful in this context.Thus, the aim of the study was to describe the association between receipt of DP and later prescriptions of benzodiazepines among non-users at baseline. METHODS: We followed a cohort reporting non-use of benzodiazepines, 6645 men and 6455 women aged 40-42 years who underwent health surveys in 1985-89 in two Norwegian counties, with respect to subsequent use of benzodiazepines by linkage to the Norwegian Prescription Database for 2004-2006. At baseline, 83 men and 163 women reported receiving DP. RESULTS: In both genders, the proportion started on at least one prescription of a benzodiazepine was approximately doubled among those reporting being on a DP 20 years in the past, 21% of all men and 29% of all women, respectively. Univariate odds ratios for a benzodiazepine prescription for men and women on a DP were 2.6 (95% confidence interval (CI) = 1.5-4.4) and 2.1 (95% CI = 1.5-2.9), respectively, as compared with those not receiving a DP. After adjustment for alcohol use, smoking habits, physical activity, socioeconomic and health variables, the odds ratios were lowered for both genders, being 2.1 (95% CI = 1.2-3.7) (men) and 1.6 (95% CI = 1.1-2.3) (women). CONCLUSIONS: For both men and women, the chance of being prescribed benzodiazepines was higher among those reporting being DP recipients 20 years in the past.

Bronchial airflow limitation, smoking, body mass index, and statin use are strongly associated with the C-reactive protein level in the elderly. The Tromsø Study 2001.

BACKGROUND: Bronchial airflow limitation is a known predictor of raised C-reactive protein (CRP) level. The aim of this study was to explore this association in an elderly population, as well as the influence of other known and possible predictors of the CRP level, like smoking and the use of statins and inhaled corticosteroids. POPULATION AND METHODS: The study population consists of 3877 Norwegians aged 60 years or more who took part in the fifth Tromsø study in 2001, a cross-sectional study. The examinations included questionnaires, spirometry and the measurement of CRP. RESULTS: A geometric mean CRP value of 3.15 mg/L was found in subjects with severe airflow limitation (FEV(1)%<50 predicted and FEV(1)/FVC<70%), compared to 1.64 mg/L in subjects with normal spirometry, (p<0.001), and 19% of the subjects with severe airflow limitation had a CRP value above 10 mg/L compared to 4.9% in those with mild airflow limitation or normal spirometry. Elevated body mass index (BMI), smoking, hormone replacement therapy, and increasing age, were also strong independent predictors of increased CRP. Statin use was a strong predictor of decreased CRP level, while the use of inhaled corticosteroids was not associated with decreased CRP values. CONCLUSION: We found a strong link between bronchial airflow limitation and the circulating CRP level in an elderly population, independent of self-reported diseases, medication, smoking, and elevated BMI. The CRP value increased with increasing age in men, but not in women, which may be partly explained by a greater impact of chronic obstructive pulmonary disease (COPD) morbidity on the CRP level in men than in women. Measuring CRP may show to be a useful part of the diagnostic work-up in COPD patients.