RESUMO
Serotonin (5-HT) is present in the gastrointestinal tract and is probably one of the compounds responsible for diarrhea in patients presenting with carcinoid syndrome. Intraperitoneal administration of L-5-hydroxytryptophan (L-5-HTP) at doses of 25 to 100 mg/kg dramatically increase defecation in mice. In this new paradigm, counting fecal boli deposited is simple and the appraised or inhibition of diarrhea induced by ip 25 mg/kg of L-5-HIP is very clear, with a good reproducibility of scores. L-5-HTP needs to be metabolized into 5-HT to be active; benserazide, an inhibitor of decarboxylase, antagonized the diarrhea induced by 5-HT. Among the 5-HT antagonists used in interaction with 5-HT, only these of the 5-HT3 type (ondansetron, granisetron, tropisetron) and, to a lesser extent 5-HT2 type (ritanserin), decreased the diarrhea induced by 5-HTP. The 5-HT4 receptor agonists from the benzamide family (metoclopramide and zacopride) increased defecation in mice but the effect failed to reach statistical significance.
Assuntos
5-Hidroxitriptofano/toxicidade , Defecação/efeitos dos fármacos , Diarreia/induzido quimicamente , Antagonistas da Serotonina/farmacologia , Agonistas do Receptor de Serotonina/farmacologia , 5-Hidroxitriptofano/administração & dosagem , 5-Hidroxitriptofano/metabolismo , Animais , Benserazida/farmacologia , Tumor Carcinoide/induzido quimicamente , Diarreia/tratamento farmacológico , Diarreia/fisiopatologia , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Inibidores Enzimáticos/farmacologia , Injeções Intraperitoneais , Masculino , Camundongos , Serotonina/metabolismo , Antagonistas da Serotonina/administração & dosagem , Agonistas do Receptor de Serotonina/administração & dosagem , EstereoisomerismoRESUMO
After having studied etiological and histological cases of 500 malignant growth of the face's skin the authors think that: -- carcinomas of lips and ears are chiefly men's cancers and above all squamous cell-tumors. Ear-tumors beeing serious. For the other parts of the face, cancers are more frequently met in females than in males. Squamous cell-tumors are perhaps more frequent than usually said; -- as for treatment the authors had rather use surgery with immediate plastic reconstruction.