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1.
Clin Nucl Med ; 48(4): e204-e206, 2023 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-36727871

RESUMO

ABSTRACT: A 79-year-old man presenting with gait disturbance and cognitive decline was diagnosed with intravascular large B-cell lymphoma (IVLBCL) by random skin biopsy. Some IVLBCL lesions were identified by PET examinations using 11 C-methionine, 18 F-FDG, and 18 F-THK5351. 11 C-methionine and 18 F-FDG uptake, which likely reflects the presence of the lymphoma cells themselves, increased clearly in the left putamen but weakly in the left deep white matter. 18 F-THK5351 uptake increased in all lesions, likely reflecting perivascular astrogliosis caused by IVLBCL. Hence, 18 F-THK5351 PET can evaluate tumor extension in IVLBCL lesions where 11 C-methionine and 18 F-FDG PET may fail in its visualization.


Assuntos
Fluordesoxiglucose F18 , Linfoma Difuso de Grandes Células B , Masculino , Humanos , Idoso , Radioisótopos de Carbono , Compostos Radiofarmacêuticos , Tomografia por Emissão de Pósitrons , Metionina
2.
Intern Med ; 62(3): 475-479, 2023 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-35831107

RESUMO

A 36-year-old man developed polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome after conversion from solitary plasmacytoma of bone to multiple myeloma. Twenty-four days following the neurological onset, he lost his independent walking ability. The level of serum vascular endothelial growth factor (VEGF) at diagnosis was 5,250 pg/mL. Three months after initiating treatment, he regained his independent walking ability in line with a reduction in the elevated serum VEGF level. Due to their genomic instability gained during conversion, myeloma cells may overproduce humoral factors and cytokines, possibly contributing to the development of neuropathy as well as the production of VEGF.


Assuntos
Doenças do Sistema Endócrino , Mieloma Múltiplo , Síndrome POEMS , Plasmocitoma , Masculino , Humanos , Adulto , Plasmocitoma/complicações , Plasmocitoma/diagnóstico , Síndrome POEMS/complicações , Síndrome POEMS/diagnóstico , Mieloma Múltiplo/complicações , Fator A de Crescimento do Endotélio Vascular
3.
Fertil Steril ; 97(4): 953-8, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22341639

RESUMO

OBJECTIVE: To investigate the expression of the implantation factors leukemia inhibitory factor (LIF), interleukin-11 (IL-11), and IL-6ST/gp130 in the endometrium to examine the relationship between loss of implantation and abnormal uterine cavity. DESIGN: Case-control study. SETTING: Department of Obstetrics and Gynecology, Tokyo Medical University. PATIENT(S): Subjects comprised 41 patients in the abnormal uterine cavity group who underwent resection of a uterine submucosal myoma or an endometrial polyp by transcervical resectoscopy (TCR) and 18 patients in the control group who underwent laparoscopic surgery. INTERVENTION(S): In the abnormal uterine cavity group, endometrial tissue specimens were obtained before resection under hysteroscopy. In the control group, endometrial tissue specimens were obtained by curettage at the time of laparoscopic surgery. MAIN OUTCOME MEASUREMENT(S): We divided the patients into four groups according to menstrual cycle and measured the endometrial expression of LIF, IL-11, and IL-6ST/gp130 with the use of quantitative real-time reverse-transcription polymerase chain reaction. RESULT(S): Significant increases in LIF and IL-11 mRNA expression were recognized during the midsecretory phase of the menstrual cycle in the control group. However, no difference in IL-6ST/gp130 mRNA expression was observed in any phase during the menstrual cycle in either group. In terms of LIF and IL-11 mRNA expression at the midsecretory phase, the abnormal uterine cavity group showed a significantly decreased LIF mRNA expression compared with the control group. CONCLUSION(S): LIF mRNA expression was significantly decreased in abnormal uterine cavities during the midsecretory phase, indicating that endometrial cavity defects are a possible cause of poor reproductive outcomes.


Assuntos
Implantação do Embrião , Leiomioma/genética , Fator Inibidor de Leucemia/genética , Pólipos/genética , Neoplasias Uterinas/genética , Útero/metabolismo , Adulto , Estudos de Casos e Controles , Receptor gp130 de Citocina/genética , Endométrio/metabolismo , Feminino , Humanos , Histeroscopia , Interleucina-11/genética , Japão , Leiomioma/patologia , Leiomioma/cirurgia , Ciclo Menstrual/genética , Pólipos/patologia , Pólipos/cirurgia , RNA Mensageiro/metabolismo , Reação em Cadeia da Polimerase em Tempo Real , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Neoplasias Uterinas/patologia , Neoplasias Uterinas/cirurgia , Útero/patologia , Útero/cirurgia
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