Serum levels of SOCS6 are decreased in diabetic retinopathy and are related to severity of the disease.

BACKGROUND: Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus (DM). A recent in vitro study found that the suppressor of cytokine signaling 6 (SOCS6) plays a protective role in DR and DM. However, to date, no clinical studies have focused on the role of SOSC6 in DR development. OBJECTIVES: The present study aimed to investigate the expression and clinical significance of serum SOCS6 in DR. MATERIAL AND METHODS: A total of 159 DR patients were enrolled in the study. Additionally, 156 type 2 DM (T2DM) patients without DR were recruited as controls. Serum levels of SOCS6, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-1ß (IL-1ß), vascular endothelial growth factor (VEGF), and angiopoietin-2 (ANG-2) were measured using enzyme-linked immunosorbent assay (ELISA). Demographic and clinical data were collected. RESULTS: Age, the course of DM, systolic blood pressure (SBP), diastolic blood pressure (DBP), and the levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were significantly higher in proliferative DR (PDR) patients. Serum SOCS6 levels in PDR patients were remarkably lower than in non-PDR patients or non-DR T2DM patients. The Pearson's analysis showed that SOCS6 was negatively correlated with CRP, IL-6, TNF-α, IL-1ß, VEGF, and ANG-2. The serum levels of CRP, IL-6, TNF-α, IL-1ß, VEGF, and ANG-2 in the SOCS6 low expression group were significantly increased compared to patients with high SOCS6 levels. Receiver operating characteristic (ROC) curves showed that SOCS6 could be a potential diagnostic biomarker for DR. For logistic regression, 3 models were used. It was found that SOCS6, the course of DM, SBP and DBP in model 1, IL-1ß and TNF-α in model 2, and VEGF and ANG-2 in model 3 were risk factors for DR. CONCLUSIONS: The SOCS6 is decreased in DR patients and is related to severity and clinical outcomes, including inflammatory and angiogenic factors.

CTSim: a numerical simulator of computed tomography for high-quality radiological education.

PURPOSE: Computer-based simulation offers radiological students the possibility to experiment with computed tomography in a way not possible in class or in clinical practice. The aim of this study was to design a computed tomography numerical simulator (CTSim) for high-quality radiological education. METHODS: In this study, a CTSim is designed based on the mathematical and physical principles of CT imaging. The proposed CTSim includes pen-beam module, fan-beam module, and clinical CT module. The core design of the software includes four parts: the construction of sample models, construction of imaging parameters and artifact parameters, design of data acquisition models under different scanning modes, and design of image reconstruction algorithm. After the design of the CTSim, the proposed CTSim was tested in every step of CT imaging. RESULTS: Systematic verification demonstrated that the proposed CTSim can not only perform raw CT data acquisition, image reconstruction, basic image processing, and image quality analysis like a real CT scanner, but can also simulate the formation of artifacts. The CTSim can completely get rid of the hardware and achieve the same experimental results as the hardware instrument. CONCLUSION: The proposed CTSim software shows several advantages such as low cost, less room accommodation, and no ionizing radiation damage and can be used as a virtual experimental training platform to enhance teaching and learning for general X-ray CT courses or for self-study of CT practitioners.

Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level.

Objective: Serum hormone deficiencies during menopause transition may affect spontaneous brain activity and global cognition. The purpose of this study was to explore the differences in spontaneous brain activity between premenopausal and perimenopausal women, and to investigate the associations between spontaneous brain activity, serum hormone levels and global cognition. Methods: Thirty-two premenopausal women (47.75 ± 1.55 years) and twenty-five perimenopausal women (51.60 ± 1.63 years) underwent resting-state functional MRI (fMRI) scan. Clinical information including Mini-Mental State Examination (MMSE), levels of estradiol (E2), free testosterone, progesterone, prolactin, follicle-stimulating hormone and luteinizing hormone were measured. Regional homogeneity (ReHo) was used to evaluate spontaneous brain activity alterations between perimenopausal and premenopausal women. Correlation analysis was used to investigate the associations between brain functional alterations and clinical measures in perimenopausal group. Results: The results demonstrated increased ReHo value in the right lingual gyrus (LG) and decreased ReHo value in the right superior frontal gyrus (SFG) in perimenopausal women compared with premenopausal women. In perimenopausal group, ReHo of the right LG showed a negative correlation with level of E2 (r = -0.586, p = 0.002), ReHo of the right SFG showed a positive correlation with level of E2 (r = 0.470, p = 0.018) and MMSE (r = 0.614, p = 0.001). Conclusions: The results demonstrated that women approaching menopause suffered from altered functions in brain regions related to cognitive function, working memory, the results also revealed a direct association between levels of E2 and brain functions in perimenopausal women.