1.
Bioorg Med Chem Lett
; 19(14): 3836-40, 2009 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19410458
RESUMO
Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores. Herein we present a pharmacokinetics and pharmacodynamics evaluation of this compound series as well as a phosphate prodrug strategy to facilitate formulation and improve oral bioavailability.