RESUMO
Two cases of mantle cell lymphoma with a unique CD8+ phenotype are reported. Both patients had disease that was resistant to therapy; one patient had the blastic variant of mantle cell lymphoma. Flow cytometric analysis of bone marrow and cerebrospinal fluid samples revealed a phenotype consistent with mantle cell lymphoma, with the additional finding of CD8 positivity in 40% or more of the tumor cells in both cases. This is the first description of such a finding, and CD8+ mantle cell lymphoma may represent a unique type of B-cell neoplasia. Our findings may be important in the prediction of therapeutic response or in the detection of residual disease after therapy.
Assuntos
Antígenos CD8/análise , Linfoma não Hodgkin/imunologia , Antígenos CD20/análise , Células da Medula Óssea/imunologia , Complexo CD3/análise , Antígenos CD5/análise , Feminino , Citometria de Fluxo , Fluoresceína-5-Isotiocianato , Corantes Fluorescentes , Humanos , Imunofenotipagem , Linfoma não Hodgkin/líquido cefalorraquidiano , Masculino , Pessoa de Meia-Idade , Receptores de IgE/análiseRESUMO
A primary end-to-end anastomosis of the esophagus can be accomplished in the wide-gap esophageal atresia by obtaining extra esophageal length through circular myotomy of the proximal esophageal pouch. However, a very short proximal esophageal pouch may not be accessible through the standard thoracic incision, precluding this procedure. An infant is reported in whom the inaccessible proximal pouch was exteriorized into the neck through a concomitant cervical incision, allowing three circular myotomies to be performed with ease. The proximal esophagus was then reintroduced into the chest cavity and a primary esophagoesophagostomy performed without difficulty.