Psychophysiological Adaptations to Exercise Training in COVID-19 Patients: A Systematic Review.

Introduction: Many COVID-19 patients display adverse symptoms, such as reduced physical ability, poor quality of life, and impaired pulmonary function. Therefore, this systematic review is aimed at evaluating the effectiveness of physical exercise on various psychophysiological indicators among COVID-19 patients who may be at any stage of their illness (i.e., critically ill, hospitalized, postdischarge, and recovering). Methods: A systematic search was conducted in PubMed, Scopus, ScienceDirect, Web of Science, and Google Scholar from 2019 to 2021. Twenty-seven studies, which assessed a total of 1525 patients, were included and analysed. Results: Overall, data revealed significant improvements in the following parameters: physical function, dyspnoea, pulmonary function, quality of life (QOL), lower limb endurance and strength, anxiety, depression, physical activity level, muscle strength, oxygen saturation, fatigue, C-reactive protein (CRP), interleukin 6 (IL-6), tumour necrosis factor-alpha (TNF-α), lymphocyte, leukocytes, and a fibrin degradation product (D-dimer). Conclusions: Physical training turns out to be an effective therapy that minimises the severity of COVID-19 in the intervention group compared to the standard treatment. Therefore, physical training could be incorporated into conventional treatment of COVID-19 patients. More randomized controlled studies with follow-up evaluations are required to evaluate the long-term advantages of physical training. Future research is essential to establish the optimal exercise intensity level and assess the musculoskeletal fitness of recovered COVID-19 patients. This trial is registered with CRD42021283087.

Treadmill exercise with nanoselenium supplementation affects the expression of Irisin/FNDC5 and semaphorin 3A in rats exposed to cigarette smoke extract.

In the current study, we investigated the impacts of 6 weeks of aerobic interval training (AIT) with selenium nanoparticles (SeNPs) on muscle, serum, and lung irisin (FNDC5) and Sema3A in rats exposed to cigarette smoke extract (CSE). To this end, 49 male Wistar rats (8 weeks old) were divided into seven groups: control, SeNPs (2.5 mg/kg b.w by oral gavage, 3 days/week, 6 weeks), AIT (49 min/day, 5 days/week for 6 weeks, interval), SeNPs + AIT, CSE (150 µL by IP injection, 1 day/week for 6 weeks), CSE + AIT, and CSE + SeNPs + AIT. The CSE group showed a significant reduction in irisin and Sema3A serum levels, as well as a decrease in FNDC5 and Sema3A gene expression in lung tissue (p < 0.05). A combined treatment (AIT with SeNPs) significantly increased the serum level and the expression of muscle and lung irisin (FNDC5) and Sema3A in CSE received groups (p < 0.05). There was a positive and significant correlation between muscle FNDC5 and lung FNDC5 in the CSE + SeNPs + AIT group (r = 0.92, p = 0.025). In addition, there was a positive and significant correlation between serum Sema3A and lung Sema3A of CSE + SeNPs + AIT group (r = 0.97, p = 0.004). Seemingly, performing aerobic exercises with the antioxidant and anti-inflammatory supplement nano-selenium in the model of lung damage (similar to COPD) can boost myokine irisin and Sema3A, especially in serum and lung tissue. These results displayed the paracrine/endocrine regulatory function of these myokines on other tissues. In other words, these interventions emphasized the creation of crosstalk between skeletal muscles and damaged lung, focusing on its recovery; however, further research is needed.

Hepatoprotective effects of moderate-intensity interval training along with ginger juice in an old male rat model.

Aging is a natural process coupled with oxidative stress and chronic inflammation, gradually associated with losing organ function over time. Therefore, the objective of the current work was to peruse the protective effects of 8-week moderate-intensity interval training (MIIT) and ginger extract supplementation on some biomarkers of oxidative stress, inflammation, and lipid metabolism in the liver of elderly males Wistar rats (animal study with ethical code IR.BMSU.REC.1401.015). A total of thirty-two 22-month-aged male Wistar rats were randomly assigned to four groups: (1) control, (2) MIIT, (3) ginger, and (4) MIIT + ginger. After 8 weeks of treadmill training and ginger extract supplementation, the biochemical parameters (liver enzyme and lipid profile), inflammatory mediators (leucine-rich α-2 glycoprotein 1 (LRG1), tumor necrosis factor-alpha, and interleukin-6), pro-oxidant (malondialdehyde), antioxidant biomarkers (catalase, superoxide dismutase, total antioxidant capacity), some lipid metabolism regulators (carnitine palmitoyltransferase 1, adipose triglyceride lipase, acetyl-CoA carboxylase, CD36, and AMP-activated protein kinase), and liver histopathological changes were appraised. The acquired findings pointed out that MIIT combined with ginger extract appreciably diminished the serum levels of LRG1, liver enzymes, and lipid profile relative to the other groups after 8 weeks of intervention. Furthermore, ginger + MIIT caused a great improvement in the liver levels of antioxidant biomarkers, pro-oxidant, pro-inflammatory biomarkers, lipid metabolism regulators, and liver tissue impairment compared to the other groups. The findings suggested that MIIT + ginger was more effective in improving examined indices relative to the other groups.

Immunoinflammatory Response to Acute Noise Stress in Male Rats Adapted with Different Exercise Training.

Objective: Noise pollution is a kind of stress that impairs various physiological functions. This study evaluated the effect of high-intensity interval training (HIIT) and moderate-intensity continuous training (MCT) on corticosterone, interleukin-6 (IL-6), and monocyte responses to acute noise stress in male rats. Design: Forty-two male Wistar rats were divided into seven groups, including control which was assessed at the beginning, control time which was assessed simultaneously with experimental groups (CT), HIIT, MCT, HIIT followed by noise stress (HIIT+S), MCT followed by noise stress (MCT+S), and noise stress. HIIT and MCT were performed for 8 weeks. Noise stress was induced for one session. Blood samples were taken 48 hours after the last exercise session in training and CT groups and immediately after acute noise stress in stress groups of HIIT+S, MCT+S, and noise stress. Results: In response to acute noise stress, MCT and HIIT adaptations increased corticosterone, while reduced monocytes compared to CT. MCT increased basal corticosterone and IL-6 and decreased monocytes; however, in response to acute noise stress, corticosterone was higher and monocyte count was lower in the HIIT+S group. Regarding the effect of training, corticosterone and monocytes in MCT were higher than in HIIT. The serum level of IL-6 was lower in MCT than CT group, while it was not significantly different between stress groups. Conclusion: In response to noise stress, previous exercise, especially HIIT, increased stress while did not increase inflammatory and innate immune response.

[Decline in work and commuting injuries during the first lockdown in the SARS-CoV-2 pandemic : Comparison to the time period 2015-2019]. / Rückgang der Arbeits- und Wegeunfälle während des 1. Lockdowns 2020 im Rahmen der SARS-CoV-2-Pandemie : Vergleich zu den Zeiträumen der Jahre 2015­2019.

BACKGROUND: Measures such as restrictions on personal contact and going out were taken to reduce SARS-CoV­2 infection numbers, ultimately resulting in the first lockdown. This was intended to create capacity in the healthcare system to manage the pandemic. AIM OF THE WORK: To analyze whether the number of work and commuting injuries decreased during the lockdown compared to the years 2015-2019. MATERIAL AND METHODS: All work and commuting accidents treated at the Klinikum rechts der Isar and the Berufsgenossenschaftliche Unfallklinik Murnau during the observational period 16 March-4 May 2020 were retrospectively compared with the figures from the same observation period in the years 2015-2019. The data on case numbers according to the transit physician procedure (DAV) were further broken down into cases of the injury type procedure (VAV) and severe injury type procedure (SAV) according to the injury type index of the German Social Accident Insurance (DGUV). In addition, the collected data were compared with data from the Federal Statistical Office on the numbers of traffic accidents and traffic fatalities. RESULTS: A total of 4313 cases were considered. In 2020, the number of work and commuting accidents decreased by 31% compared to the observation period 2015-2019. VAV cases were decreased by 26% in 2020. SAV cases decreased by 5% in 2020. Road traffic accidents decreased by 17% in thre first four months in 2020 compared to the first four months in 2019. Traffic fatalities decreased by 11%. DISCUSSION: There was a 31% decrease in work and commuting accidents. This contributed to resource reallocation in the context of the pandemic. Nevertheless, almost constant numbers of severely injured patients and accidental deaths occurred, which shows the relevance of trauma surgery structures especially in times of crisis and makes it indispensable to include them in the calculation of intensive care resources.