Assuntos
Câmara Anterior/patologia , Neoplasias da Íris/diagnóstico , Sarcoma Mieloide/diagnóstico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Evolução Fatal , Humanos , Lactente , Neoplasias da Íris/tratamento farmacológico , Imageamento por Ressonância Magnética , Masculino , Invasividade Neoplásica , Sarcoma Mieloide/tratamento farmacológicoRESUMO
Meningioma is the most common intracranial non-glial tumour of cats, dogs and man. Few spontaneously arising brain tumours have been reported in non-human primates. This report describes a meningioma in a captive baboon. Clinical signs exhibited by the animal included head pressing, visual impairment and vestibular disease. The tumour arose from the ventral aspect of the cranial cavity and compressed the overlying left side of the cerebellum and brainstem. Microscopically, the mass was characterized by pleomorphic spindle-shaped to polygonal cells arranged in sheaths, vague whorls and occasional papillary structures on vascular cores. Nuclear cytoplasmic invagination, syncytial-like cells and areas of mineralization were also evident. Immunohistochemically, the neoplastic cells expressed vimentin and S-100 protein, but not pancytokeratin, glial fibrillary acidic protein or epithelial membrane antigen. The features of this tumour are similar to those of meningiomas in other species.
Assuntos
Neoplasias Meníngeas/veterinária , Meningioma/veterinária , Papio , Doenças dos Primatas/patologia , Animais , Feminino , Transtornos Neurológicos da Marcha/etiologia , Transtornos Neurológicos da Marcha/veterinária , Humanos , Hidrocefalia/etiologia , Hidrocefalia/veterinária , Mamíferos , Neoplasias Meníngeas/complicações , Neoplasias Meníngeas/patologia , Meningioma/complicações , Meningioma/patologia , Especificidade da Espécie , Doenças Vestibulares/etiologia , Doenças Vestibulares/veterinária , Transtornos da Visão/etiologia , Transtornos da Visão/veterináriaRESUMO
Retinoblastoma is the most common primary intraocular tumor in childhood. Diffuse anterior retinoblastoma is an uncommon variant and usually occurs in comparatively older children. Typically, there is an extensive infiltration of the anterior segment by tumor cells clinically mimicking anterior uveitis with pseudohypopyon. The actual retinal focus is often very small and may not be detected despite a thorough histological examination. In this case report the clinical and histological findings of a diffuse anterior retinoblastoma are described.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Neoplasias da Retina/tratamento farmacológico , Neoplasias da Retina/patologia , Retinoblastoma/tratamento farmacológico , Retinoblastoma/patologia , Carboplatina/administração & dosagem , Pré-Escolar , Etoposídeo/administração & dosagem , Humanos , Masculino , Resultado do Tratamento , Vincristina/administração & dosagemRESUMO
We report a case of intraocular lacrimal gland choristoma presenting very early in a preterm infant with hyphema, a mass lesion and raised intraocular pressure. Enucleation of the involved eye, which is the treatment in most cases, was performed and prosthesis was fitted successfully. An interesting additional finding in our patient was a choroidal defect, not reported to date with other cases in the literature.
Assuntos
Corticosteroides/uso terapêutico , Coristoma , Doenças do Prematuro , Doenças da Íris , Aparelho Lacrimal , Coristoma/complicações , Coristoma/diagnóstico , Coristoma/fisiopatologia , Coristoma/terapia , Corioide/patologia , Enucleação Ocular , Humanos , Hifema/complicações , Hifema/terapia , Recém-Nascido , Recém-Nascido Prematuro , Doenças da Íris/complicações , Doenças da Íris/diagnóstico , Doenças da Íris/fisiopatologia , Doenças da Íris/terapia , Hipertensão Ocular/complicações , Hipertensão Ocular/terapia , Resultado do TratamentoRESUMO
BACKGROUND: Gallbladder pathology (GBP) is a relatively uncommon, naturally occurring morbidity in both baboons and humans. METHODS: A retrospective analysis was performed on 7776 necropsy reports over a 20 year period to determine the prevalence of baboon GBP. RESULTS: Ninety-seven cases of GBP were identified, yielding a 20 year population prevalence of 1.25%. GBP is more common in adult female baboons, occurring with a female to male ratio of nearly 2:1. Among gallbladder pathologies, cholecystitis (35.1%) and cholelithiasis (29.9%) were the most prevalent abnormalities, followed by hyperplasia (16.5%), edema (15.5%), amyloidosis (5.2%), fibrosis (4.1%), necrosis (4.1%), and hemorrhage (1.0%). CONCLUSION: Many epidemiologic similarities exist between GBP in baboons and humans suggesting that the baboon may serve as a reliable animal model system for investigating GBP in humans.
Assuntos
Doenças da Vesícula Biliar/veterinária , Doenças dos Macacos/patologia , Papio , Fatores Etários , Animais , Feminino , Doenças da Vesícula Biliar/epidemiologia , Doenças da Vesícula Biliar/patologia , Cálculos Biliares/química , Histocitoquímica/veterinária , Masculino , Doenças dos Macacos/epidemiologia , Prevalência , Estudos Retrospectivos , Texas/epidemiologiaRESUMO
BACKGROUND: In previous studies, the length of the glandulo-metaplastic esophageal mucosa (GMEM) at the gastroesophageal junction was assessed in a selected group of baboons. In this study, the length of the GMEM was measured in the entire esophagus in a cohort of unselected adult baboons. MATERIALS AND METHODS: In 15 female baboons, the entire esophagus was removed en bloc at autopsy, from the tongue to the angle of His. No part of the stomach was included. The length of GMEM was measured using a calibrated ocular microscale. RESULTS: GMEM was found in 11 out of the 15 esophagi. The total length of GMEM recorded in the 11 cases was 115 mm (mean 10.5 mm, range 1-45 mm). The mean age for animals with GMEM was 15.5 years (range 7-32 years) and for animals without GMEM was 14.0 years (range 7-20 years); the difference was non-significant (p<0.6). No significant association was found between the length of the GMEM and the age of the animals (p<0.6). CONCLUSION: This study substantiates the notion that GMEM in baboons is a postnatal physiological adaptative process of the esophageal mucosa to daily regurgitation with rumination of gastric juices of low pH. The GMEM apparently progresses upwards, along the esophageal mucosa. The baboon might be an excellent animal model to study the series of histological events that take place in the distal esophagus under the influence of protracted gastroesophageal reflux.
Assuntos
Esôfago de Barrett/veterinária , Esôfago/patologia , Doenças dos Macacos/patologia , Papio , Adaptação Fisiológica , Animais , Esôfago de Barrett/metabolismo , Esôfago de Barrett/patologia , Esôfago/metabolismo , Esôfago/fisiopatologia , Feminino , Refluxo Gastroesofágico/fisiopatologia , Células Caliciformes/metabolismo , Células Caliciformes/patologia , Metaplasia , Doenças dos Macacos/metabolismo , Mucosa/metabolismo , Mucosa/patologiaRESUMO
BACKGROUND: Study of endocrine pathology in animal models is critical to understanding endocrine pathology in humans. METHODS: We evaluated 434 endocrine-related diagnoses from 4619 baboon necropsies, established the incidence of spontaneous endocrine pathology, and analyzed the clinical and biochemical data associated with the individual cases. RESULTS: The most common diagnoses in descending order, were pancreatic islet cell amyloidosis (n = 259), ovarian cysts (n = 50), pituitary adenoma (n = 37), pancreatic islet cell adenoma (n = 20), granulosa cell tumor (n = 15), thyroid adenoma (n = 11), adrenal hyperplasia (n = 10), thyroid carcinoma (n = 8), and pheochromocytoma (n = 6). The incidence of pancreatic islet cell amyloidosis progressively increased with age. Pheochromocytomas were associated with renal and heart failure. The incidence of pancreatic islet cell amyloidosis and adrenal pathology was similar to humans; the incidence of pituitary adenoma and thyroid pathology was lower than in humans. CONCLUSIONS: Endocrine disease in baboons is common and shares clinical and biochemical characteristics with endocrine disease in humans.
Assuntos
Doenças do Sistema Endócrino/veterinária , Doenças dos Macacos/epidemiologia , Papio , Animais , Comorbidade , Doenças do Sistema Endócrino/epidemiologia , Feminino , Humanos , Incidência , MasculinoRESUMO
Maternal obesity is present in 20-34% of pregnant women and has been associated with both intrauterine growth restriction and large-for-gestational age fetuses. While fetal and placental functions have been extensively studied in the baboon, no data are available on the effect of maternal obesity on placental structure and function in this species. We hypothesize that maternal obesity in the baboon is associated with a maternal inflammatory state and induces structural and functional changes in the placenta. The major findings of this study were: 1) decreased placental syncytiotrophoblast amplification factor, intact syncytiotrophoblast endoplasmic reticulum structure and decreased system A placental amino acid transport in obese animals; 2) fetal serum amino acid composition and mononuclear cells (PBMC) transcriptome were different in fetuses from obese compared with non-obese animals; and 3) maternal obesity in humans and baboons is similar in regard to increased placental and adipose tissue macrophage infiltration, increased CD14 expression in maternal PBMC and maternal hyperleptinemia. In summary, these data demonstrate that in obese baboons in the absence of increased fetal weight, placental and fetal phenotype are consistent with those described for large-for-gestational age human fetuses.
Assuntos
Adaptação Fisiológica , Modelos Animais de Doenças , Obesidade , Papio , Placenta/patologia , Placenta/fisiopatologia , Complicações na Gravidez , Sistema A de Transporte de Aminoácidos/metabolismo , Aminoácidos/sangue , Animais , Peso Corporal , Vilosidades Coriônicas/patologia , Estatura Cabeça-Cóccix , Feminino , Sangue Fetal , Inflamação/metabolismo , Rim/patologia , Leptina/sangue , Leucócitos Mononucleares/metabolismo , Receptores de Lipopolissacarídeos/análise , Receptores de Lipopolissacarídeos/sangue , Receptores de Lipopolissacarídeos/metabolismo , Macrófagos/patologia , Análise por Pareamento , Troca Materno-Fetal , Obesidade/patologia , Obesidade/fisiopatologia , Tamanho do Órgão , Gravidez , Complicações na Gravidez/patologia , Complicações na Gravidez/fisiopatologia , Trofoblastos/patologiaRESUMO
BACKGROUND: Chimpanzees have over 98% genomic sequence homology with humans and may have a similar host response to malignancy. There is minimal information concerning cancer in the chimpanzee and such information would be valuable to individuals caring for and using them for research. METHODS: Spontaneous neoplasia that was documented in two chimpanzee colonies and in the literature were evaluated statistically. RESULTS: In all, 105 spontaneous and 12 experimental neoplasms were diagnosed. Seventy-four spontaneous tumors occurred in females, 24 in males,and seven in animals of undetermined sex. Of the spontaneous tumors 89 were benign, 14 were malignant, and two were undetermined. Neoplasia was most common in the urogenital system in females. CONCLUSIONS: Neoplasia is not uncommon in the chimpanzee, is generally benign, and occurs primarily in the urogenital system in females.
Assuntos
Doenças dos Símios Antropoides/diagnóstico , Neoplasias/veterinária , Pan troglodytes , Animais , Feminino , Leiomioma/diagnóstico , Masculino , Neoplasias/diagnóstico , Neoplasias Uterinas/diagnósticoRESUMO
BACKGROUND: Gastrointestinal stromal tumors (GISTs) are believed to originate from the intestinal pacemaker cells (interstitial cells of Cajal) or their progenitor cells. Spontaneous tumors have been reported in dogs, horses, rhesus, and a chimpanzee and they have been produced experimentally in mice and rats. GISTs represent a diagnostic challenge because they cannot be differentiated from non-lymphoid mesenchymal tumors without using human c-kit (CD117) immunohistochemistry. METHODS: Three neoplasms were incidental findings at necropsy in the stomachs of a baboon and a spider monkey and in the rectum of a chimpanzee. RESULTS: The GISTs were initially diagnosed grossly and histologically with hematoxylin and eosin as leiomyomas. Immunohistochemical analysis revealed that all three were c-kit (CD117) positive. CONCLUSIONS: These are the first reports of GISTs in the baboon and spider monkey and the second in a chimpanzee. The occurrence of GISTs in non-human primates may provide a unique opportunity to study these tumors.
Assuntos
Atelinae , Tumores do Estroma Gastrointestinal/veterinária , Pan troglodytes , Papio , Doenças dos Primatas/patologia , Animais , Feminino , Tumores do Estroma Gastrointestinal/patologia , Imuno-Histoquímica/veterinária , Masculino , Proteínas Proto-Oncogênicas c-kit/análiseRESUMO
The baboon is an established model for endometriosis research. This report describes the occurrence of spontaneous endometriosis involving the ileocaecal junction and associated regional lymph nodes in the baboon. All endometriotic foci lacked the nuclear atypia, abnormal mitotic activity and altered nuclear-to-cytoplasmic ratio typical of malignancy. These findings are identical to reports in the human in which ileocaecal and colonic endometriosis is associated with endometriosis in pericolonic and mesenteric lymph nodes. The similarity between baboon and human colonic endometriosis in both location and pathology is striking and lends further evidence supporting the validity of the baboon as a model for human endometriosis.
Assuntos
Doenças do Colo/patologia , Endometriose/veterinária , Valva Ileocecal/patologia , Linfonodos/patologia , Animais , Colo , Modelos Animais de Doenças , Endometriose/patologia , Feminino , Humanos , PapioRESUMO
PURPOSE: During ageing, there may be an age-associated loss of particular nerve cells in specific brain areas. Recent studies highlight the role of apoptosis in the normal ageing of the brain, heart, and skeletal muscle. Particular attention is paid to the role of cytochrome c release from mitochondria and alterations in the pro- and anti-apoptotic proteins, Bax and Bcl-2, respectively. The aim of this study was to investigate the potential occurrence of apoptosis in the hippocampus of aged baboons. METHODS: we have used the baboon as a potential non-human primate model for age-related pathology which afflicts the human brain. The TUNEL staining method was used to characterise the apoptotic cell death. For immunocytochemistry, antibodies directed against activated caspase-3, cytochrome c, Bcl-2 and Bax proteins were used. RESULTS: Our results show that in hippocampi of aged baboons the immunoreactivities of the antiapoptotic agent Bcl-2 was not prominently changed, of the proapoptotic agent Bax was upregulated, of the cytochrome c was redistributed, and that caspase-3 was not activated. The TUNEL-staining method revealed no apoptotic cell death in hippocampi of aged baboons. CONCLUSIONS: This demonstrates that a specific alteration of the Bax/Bcl2 ratio occurs in the ageing baboon hippocampus which may directly influence the release of cytochrome c even without commitment to apoptosis.
Assuntos
Envelhecimento/metabolismo , Apoptose/fisiologia , Citocromos c/metabolismo , Hipocampo/citologia , Hipocampo/metabolismo , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Animais , Feminino , Hipocampo/enzimologia , Imuno-Histoquímica , Masculino , Papio , Proteína X Associada a bcl-2RESUMO
Pulmonary congenital anomalies in animals are rare. Previously reported malformations include accessory lung formation, pulmonary hypoplasia, pulmonary agenesis, and various forms of hamartoma. Congenital bronchiolo-alveolar airway malformation, a new entity, is described in a 1-day-old male cynomolgus macaque. This neonate experienced breathing difficulties shortly after birth and died while therapy was being administered. Grossly, the right lung was markedly increased in size, firm, and pink. Histopathologically, sections of right lung showed irregular bronchiole-like and alveolus-like structures. There was marked widening of alveolar septae by loosely arranged mesenchymal cells and many centrally located capillaries. Alveoli were lined by cuboidal epithelial cells. There were scattered islands of immature cartilage. A grossly enlarged lung containing bronchiole-like and alveolus-like structures, immature cartilage islands, and many capillaries within alveolar septae on histopathologic examination, is inconsistent with previously described congenital pulmonary anomalies in animals and humans.
Assuntos
Pulmão/anormalidades , Macaca fascicularis/anormalidades , Animais , Evolução Fatal , Técnicas Histológicas , Pulmão/patologia , Masculino , Alvéolos Pulmonares/anormalidades , Alvéolos Pulmonares/patologiaRESUMO
Glioblastoma multiforme is the most malignant astrocytic neoplasm and the most common brain neoplasm of humans. Spontaneous neoplasms of the brain are rare in nonhuman primates. This report describes three glioblastomas in adult captive-reared baboons. The animals exhibited a range of clinical signs, including depression, weight loss, weakness, and blindness. All three neoplasms were located in the cerebrum, with extension into the pons in one case. Histologically, the tumors were similar and were characterized by cellular pleomorphism, multinucleated cells, areas of necrosis, microvascular proliferation (glomeruloid bodies), and palisading of neoplastic cells around blood vessels and areas of necrosis. Two baboons exhibited gemistocytic differentiation, and in one baboon, the neoplastic cells were predominantly spindle shaped with a fascicular growth pattern. Immunohistochemical staining for glial fibrillary acidic protein, vimentin, and S-100 protein was positive, whereas immunostaining for synaptophysin and chromogranin A was negative. Positive staining for the cell proliferation marker Ki67 ranged from 8.2% to 13.9%. Terminal deoxynucleotidyl transferase mediated dVTPnick end labeling (TUNEL) staining ranged from 1.8% to 5.7%. These baboon glioblastomas share many features with those of humans.
Assuntos
Neoplasias Encefálicas/veterinária , Glioblastoma/veterinária , Doenças dos Macacos/patologia , Papio , Animais , Biomarcadores Tumorais/análise , Neoplasias Encefálicas/química , Neoplasias Encefálicas/patologia , Feminino , Glioblastoma/química , Glioblastoma/patologia , Imuno-Histoquímica/veterinária , Marcação In Situ das Extremidades Cortadas/veterinária , Masculino , Proteínas do Tecido Nervoso/análiseRESUMO
Over 23 months, zinc toxicosis was diagnosed in 35 baboons aged 5-12 months in one galvanized metal and concrete cage complex with conditions that led to excessive exposure to environmental zinc. Clinical signs included reduced pigmentation of hair, skin, and mucous membranes (whiteness), alopecia, dehydration, emaciation, cachexia, dermatitis, diarrhea and, in six cases, severe gangrenous dermatitis of extremities. The syndrome was characterized by pancytopenia, elevated zinc and low copper serum concentrations, low vitamin D and bone-specific alkaline phosphatase levels, and atypical myelomonocytic proliferation of bone marrow. This syndrome emphasizes the importance of proper husbandry and cage design and indicates the potential of infant baboons as a model to study the effects of excessive zinc on development. This is the first report describing the epidemiologic and clinical presentation of zinc toxicosis in infant baboons in captivity.
Assuntos
Exposição Ambiental , Abrigo para Animais , Doenças dos Macacos/patologia , Papio , Vitamina D/análogos & derivados , Zinco/intoxicação , Alopecia/etiologia , Alopecia/veterinária , Análise de Variância , Anemia/etiologia , Anemia/veterinária , Animais , Osso e Ossos/diagnóstico por imagem , Cobre/sangue , Cobre/deficiência , Proteínas de Ligação a DNA/sangue , Dermatite/etiologia , Dermatite/veterinária , Diarreia/etiologia , Diarreia/veterinária , Citometria de Fluxo/veterinária , Cariotipagem/veterinária , Luz , Fator de Transcrição PAX5 , Pigmentação/efeitos dos fármacos , Radiografia , Radioimunoensaio/veterinária , Síndrome , Fatores de Transcrição/sangue , Vitamina D/sangue , Zinco/sangueRESUMO
Spontaneous endometriosis was diagnosed in 43 baboons over a 14-year period. Thirty-seven have died; five remain alive; one was sold and lost to follow-up. The average age at diagnosis was 17.2 years; 29 (67%) were between 12 and 21 years of age. Fifteen (35%) were diagnosed by biopsy and received surgical excision of the endometriotic tissue; four of these were identified during caesarian section, confirming one prior report of endometriosis in pregnant animals. Twenty-eight (65%) were diagnosed at or shortly preceding necropsy. When diagnosed by a palpable abdominal mass, there was a significantly greater likelihood the animal died or was killed as a result of complications of endometriosis. When diagnosis was at necropsy, there was a significantly greater likelihood that the animal died from causes unrelated to endometriosis. Early identification with surgical removal appears to provide a benefit for both survival and delivering offspring after diagnosis. In twenty-one baboons (49%), endometriosis affected multiple sites within the peritoneal cavity. In the remaining baboons, lesions were more localized. Ovarian involvement was seen in sixteen (37%) of these baboons. This paper is the first to describe significant ovarian involvement in baboons, previously considered a limitation of the usefulness of this species as an animal model. We also describe the first reported endometriosis seeding of an abdominal surgery scar in a baboon. Many of these baboons were middle aged, had few or no offspring, or had evidence of a long duration of uninterrupted menstrual cycles, consistent with risk factors for women. Endometriosis was an incidental finding in 17 (40%) of these baboons, consistent with previous reports of minimal endometriosis as a common asymptomatic finding in baboons and in women. Overall, endometriosis in baboons presents a spontaneously occurring animal model that shares important features with the disease in women and the rhesus macaque.
Assuntos
Endometriose/veterinária , Doenças dos Macacos/epidemiologia , Papio , Idade de Início , Animais , Modelos Animais de Doenças , Feminino , Gravidez , História ReprodutivaRESUMO
Spontaneous amyloidosis occurs in many nonhuman primate species but remains difficult to diagnose and treat. Nonhuman primates continue to offer promise as animal models in which to study amyloidosis in humans. Amyloidosis was not diagnosed clinically but was found histologically in four male and 36 female baboons. The baboons averaged 18 years of age at death (range, 7-28 years). Clinical signs, if present, were hyperglycemia and cachexia. Blood glucose values were elevated in 12 of 30 baboons with available clinical pathology data. Four baboons had been clinically diagnosed as diabetic and three were treated with insulin. Amyloid was found in the islets of Langerhans of the pancreas in 40 baboons; 35 baboons had amyloid only in the islets of Langerhans. Amyloid was found in nonislet tissue of baboons as follows: five, nonislet pancreas; four, intestine and adrenal; three, kidney; two, prostate and spleen; and one each, lymph node, liver, gall bladder, stomach, tongue, urinary bladder, and salivary gland. Sections of paraffin-embedded tissues were evaluated for amyloid with hematoxylin and eosin (HE) and congo red (CR) staining, and using immunohistochemistry for human islet amyloid polypeptide (IAPP), calcitonin gene-related peptide (CGRP), glucagon, pancreatic polypeptide (PP), somatostatin (SS), and porcine insulin. Islet amyloid was positive with HE in 40 baboons, with CR in 39 baboons, and with IAPP and CGRP in 35 baboons. IAPP and CGRP only stained islet amyloid. PP, SS, glucagon, and porcine insulin did not stain amyloid. Islet amyloidosis in the baboon appears to be difficult to diagnose clinically, age-related, and similar to islet amyloidosis in other species. The baboon may be a good model for the study of islet amyloidosis in humans.
Assuntos
Amiloide/análise , Amiloidose/veterinária , Ilhotas Pancreáticas/patologia , Papio , Amiloidose/diagnóstico , Amiloidose/patologia , Animais , Glicemia/análise , Diabetes Mellitus/veterinária , Modelos Animais de Doenças , Feminino , Imuno-Histoquímica , MasculinoRESUMO
PURPOSE: To evaluate potential toxic effects of indocyanine green dye on cultured human retinal pigment epithelial cells. METHODS: Controlled laboratory experiment. Cultured human retinal pigment epithelial cells were exposed to balanced saline solution, balanced saline solution with endoillumination, indocyanine green or indocyanine green with endoillumination. Cells were evaluated by light microscopy, electron microscopy, and a mitochondrial dehydrogenase assay. RESULTS: Retinal pigment epithelial cells exposed to indocyanine green showed no histologic or ultrastructural changes. Those exposed to indocyanine green alone or indocyanine green plus light demonstrated a significant decrease in mitochondrial enzyme activity (P = 0.0002 and 0.005, respectively). CONCLUSION: Brief exposure of cultured human retinal pigment epithelial cells to indocyanine green results in decreased mitochondrial enzyme activity but does not appear to influence cellular morphology or ultrastructure.
Assuntos
Corantes/farmacologia , Verde de Indocianina/farmacologia , Epitélio Pigmentado Ocular/efeitos dos fármacos , Perfurações Retinianas/cirurgia , Células Cultivadas , Ensaio de Imunoadsorção Enzimática , Humanos , Mitocôndrias/efeitos dos fármacos , Mitocôndrias/enzimologia , Oxirredutases/metabolismo , Epitélio Pigmentado Ocular/enzimologia , Epitélio Pigmentado Ocular/ultraestruturaRESUMO
Clinical skin disease in the NHP is common and generally similar in appearance, clinical approach, and therapy to that seen in other animals and humans. Because most skin diseases of NHP are potentially zoonotic, care must be taken when handling the animals. Traumatic injury to the skin with secondary bacterial infection is the most common condition seen clinically. Virus-induced skin disease is probably the next most commonly seen, followed by mycotic infections, parasitisms, cancer, and miscellaneous rare conditions.
Assuntos
Haplorrinos , Doenças dos Macacos/patologia , Dermatopatias/veterinária , Animais , Dermatopatias/patologiaRESUMO
Ubiquitin and alpha B-crystallin belong to a class of proteins which are overexpressed in a variety of human neuropathological conditions associated with increased cellular stress. In this study we have examined the brains of aged rhesus monkeys (Macaca mulatta; n = 10, mean age: 29.7 years) using antibodies against the stress proteins ubiquitin, alpha B-crystallin, and heat shock protein 27 (hsp27). Here, we demonstrate an increased expression of ubiquitin, alpha B-crystallin, and hsp27 in spheroid bodies predominantly localized in the globus pallidus and pars reticulata of the substantia nigra. A portion of the pallido-nigral spheroids also contained ferric iron as highlighted by Perls' staining. On the basis of these findings we advance the hypothesis that expression of ubiquitin, alpha B-crystallin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys represents a stress response possibly related to increased iron-mediated oxidative stress.