Influence of polyvinylpyrrolidone, microcrystalline cellulose and colloidal silicon dioxide on technological characteristics of a high-dose Petiveria alliacea tablet.

PURPOSE: Petiveria alliacea L. (Phytolaccaceae) is a perennial shrub used by its immunomodulatory, anticancerogenic and anti-inflammatory properties. This study determined the influence of polyvinylpyrrolidone (PVP), colloidal silicon dioxide (CSD) and microcrystalline cellulose (MC) on the technological characteristic of a high-dose P. alliacea tablet prepared by the wet granulation method. METHODOLOGY: The botanical and pharmacognostic analysis of the plant material was firstly performed, followed by a 23 factorial design considering three factors at two levels: (a) the binder (PVP) incorporated in formulation at 10% and 15% (w/w); (b) the compacting agent (CSD) added at 10% and 15% (w/w) and; (c) the diluent (MC) included at 7.33% and 12.46% (w/w). The analysis of pharmaceutical performance and the accelerated and long-term stability of the best prototype were also completed. RESULT AND DISCUSSION: The binder, compacting agent and the interaction binder/diluent had a significant impact on breaking force of high-dose P. alliacea tablet. The optimum formula was found to contain 15% (w/w) of CSD, 7.33% (w/w) of MC and 10% (w/w) of PVP. At these conditions, the tablet shows a breaking force of 77.96 N, a friability of 0.39%, a total phenol content of 1.30 mg/tablet and a maximum disintegration time of 6 min. CONCLUSIONS: The use of adequate amounts of PVP, MC and CSD as per the factorial design allowed the preparation of a tablet suitable for administration, despite the inappropriate flow and compressibility properties of the P. alliacea powder.

Formulación de tabletas a partir del Extracto de Mangifera indica L (Vimang®) / Dosage form of pills from the Extract of Mangifera L indica (vimang®)

Partiendo del conocimiento etnomédico documentado de varios países sobre los beneficios que reporta la planta Mangifera indica L. para la salud humana -- conocida en Cuba como mango -- y en particular de la experiencia acumulada durante más de 20 años en la población cubana, han sido desarrollados e introducidos en la práctica social varios productos elaborados en diferentes formas con su extracto acuoso, entre las cuales se encuentra la tableta, identificada con la marca comercial VIMANG y registrada por el Centro de Química Farmacéutica. En el presente trabajo se brinda una información general sobre la planta, así como los resultados del estudio de formulación realizado del extracto de Mangifera indica L en comprimidos; forma farmacéutica muy utilizada en el ejercicio médico, de la cual se expone una panorámica actual. Las tabletas obtenidas cumplieron todas las especificaciones de calidad requeridas y fueron registradas como antioxidantes