RESUMO
The activities of renal phenolsulfotransferase and arylsulfatases A and B were estimated in 400 male Swiss albino mice classified into four groups: Normal controls, Schistosoma mansoni infected group, Dimethylnitrosamine (DMN) treated group and infected treated group. The activity levels of the studied enzymes were significantly increased in all groups when compared with the control group, also the statistical analyses showed a high significant increase of the three enzymes levels in the infected treated group; when compared separately with treated or infected groups. It was concluded, therefore, that schistosomal infection is implicated in the development of kidney cancer which may arise from the pattern of hepatic mixed-function oxidase induction characterized for schistosomiasis and its temporal relationship with the procarcinogenic initiating events. Furthermore, the striking significant increase in the enzymatic activity levels of the acid hydrolases arylsulfatases due to the lesion of both cytotoxic effects of dimethylnitrosamine as well as pathological change of schistosomiasis which may play an active role in the initiation of the malignant process by detoxifying endogenous sulfated aromatic metabolites.
Assuntos
Arilsulfotransferase/metabolismo , Cerebrosídeo Sulfatase/metabolismo , Dimetilnitrosamina/toxicidade , Modelos Animais de Doenças , N-Acetilgalactosamina-4-Sulfatase/metabolismo , Esquistossomose mansoni , Animais , Biotransformação , Testes de Carcinogenicidade , Carcinógenos/toxicidade , Cocarcinogênese , Citosol/enzimologia , Relação Dose-Resposta a Droga , Rim/enzimologia , Testes de Função Renal , Neoplasias Renais/induzido quimicamente , Neoplasias Renais/parasitologia , Lisossomos/enzimologia , Masculino , Camundongos , Esquistossomose mansoni/complicações , Esquistossomose mansoni/enzimologia , Esquistossomose mansoni/imunologia , Fatores de TempoRESUMO
The level of adenosine deaminase (ADA) and arylsulphatase A (ASA) in the sera of 22 patients with acute lymphoblastic leukemia (ALL) were significantly increased when compared with the control healthy group. Also, there is a significant increase in the activity of these enzymes in patients with ALL with central nervous system (CNS) infiltration when compared with patients of ALL without CNS infiltration. We conclude that the estimation of ADA and ASA in the serum may be useful for detection of the early infiltration of the central nervous system by leukemic cells in acute lymphoblastic leukemia.