[Determination of anti-core antibodies with the immunoenzymatic method. Comparison with the radioimmunological method]. / Determinazione degli anticorpi anti-core con metodo immunoenzimatico. Confronto con la metodica radioimmunologica.

The authors tested 366 samples for the detection of HBcAb using enzyme-linked immunosorbent assay (ELISA) and radioimmuno assay (RIA). Twenty samples were titered to compare the sensitivity of the two tests. The results showed that the two methods gave very similar results, with only a few doubtful cases for RIA. ELISA seems to be more sensitive than RIA for the titration of the positive samples. The authors conclude that the ELISA method is easier than RIA and does not require any apparatus in particular.

[Association of serum tumor markers in solid neoplasms (CEA, ferritin, alpha 1-antitrypsin, parathormone and calcitonin)]. / Studio di una associazione di markers tumorali sierici in alcune neoplasie solide (CEA, ferritina, alfa-1-antitripsina, paratormone e calcitonina).

The Authors have tested serum levels of CEA, ferritin, Alpha-1-antitrypsin, parathyroid hormone (PTH) and calcitonin (CT) in 286 patients affected by lung, gastrointestinal, breast and other kinds of cancer and by non neoplastic diseases. 50 healthy subjects were tested as matched controls too. None of the tested patients was subjected to blood transfusion, therapy with iron, radio- or chemotherapy before the blood drawing. Cea, ferritin, PTH and CT were tested by radioimmunoassay; AAT by laser nephelometry. All the healthy subjects showed serum levels of the markers in the normal ranges. Also the percent of cases with contemporaneous pathological markers was examined. The obtained data have been statistically controlled with "chi square" test. The results show that CEA, ferritin, AAT and CT are higher in the tumor groups than in the others. On the contrary PTH seems to be not useful as tumor marker. The Authors conclude affirming that it is not possible to use any of the tested substances as a specific tumor marker but it is useful to test at the same time these markers in the patients suspected to be affected by cancer for an early diagnosis and therapy, as there are few false positive and false negative cases.

[Serum tumor markers in lung neoplasms (correlation with histological types)]. / Utilizzazione di alcuni markers tumorali sierici nelle neoplasie del polmone (rapporto con i quadri istologici).

The AA. have tested serum levels of ferritin, alpha-1-antitripsyn, C4 and Phosphohexoseisomerase (PHI) in 50 patients affected by primary lung cancer, 40 patients affected by chronic lung diseases and a control group of 40 healthy males and females. All the test have a percentage of pathological case higher in the group of neoplasms than in the group of chronic diseases and ferritin seems to have the highest sensitivity. Obtained results have been correlated also to the morphoradiological and histological kind of neoplasm. "Peripheral" morphoradiological kind and III WHO histological kind are the group with more pathological cases. All the data have been statistically controlled.

[Effect of atropine on hypophyseal gonadotropins in the basal condition and under GnRH stimulation]. / Azione dell'atropina sulle gonadotropine ipofisarie in condizioni basali e dopo stimolo con GnRH.

The Authors have tested serum levels of LH and FSH in 10 healthy males after stimulation test with GnRH preceded by administration i.m. of 1 mg. of atropine 10' and 1 hour before the test, to examine some interferences of the drug on ipophisary gonadotropins. Atropine has no effect on LH and FSH release because there are no differences between mean values of the hormones during the test with and without atropine, at any time it is administered. All the data obtained have been controlled with Student's "t" test.

[Serum levels of GPI, AAT and CEA in primary lung neoplasms and chronic bronchopneumopathies]. / I livelli sierici di GPI, A1AT e CEA nelle neoplasie polmonari primitive e nelle broncopneumopatie croniche.

The Authors have tested serum levels of alpha-1-antitrypsin (A1AT), phosphohexose-isomerase (GPI) and carcinoembryonic antigen (CEA) in 133 patients affected with primary lung cancer, not treated with any drug, and in 183 patients affected with not neoplastic lung diseases or healthy, to control the utility of these markers in the early diagnosis of lung cancer. In many patients all the tests have been made at the same time. The three tumoral markers have been also examined in connection with the histological kinds of lung cancer. Results show that is suitable to test GIP and A1AT at the same time because they are percentually more pathological; serum levels of CEA, that are not very elevated in the pathological cases, seem in correlation with the histological kind of cancer.