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1.
J Med Case Rep ; 16(1): 83, 2022 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-35216628

RESUMO

BACKGROUND: Meniscoid lesions have been reported in patients with chronic ankle injuries, especially in soccer athletes, and such lesions cause soft-tissue impingement and pain. To our knowledge, we are the first to report a meniscoid lesion in the ankle joint presenting as a long-term sequela of avascular necrosis of the talus that developed in childhood. CASE PRESENTATION: In this paper, we describe a 55-year-old Caucasian male patient who presented with a 1-year history of intermittent locking, "giving way," weight-bearing pain, and swelling over the anterior aspect of the ankle joint. Imaging showed a rare case of avascular necrosis of the talus associated with an unstable plica-like lesion that was removed arthroscopically after unsuccessful conservative treatment. CONCLUSION: We demonstrate that unstable meniscoid lesions of the ankle joint can be treated successfully with arthroscopic debridement. We obtained satisfactory short-term clinical results at the 2-year follow-up, even though advanced osteoarthritis was present.


Assuntos
Traumatismos do Tornozelo , Osteonecrose , Futebol , Tálus , Traumatismos do Tornozelo/complicações , Traumatismos do Tornozelo/diagnóstico por imagem , Traumatismos do Tornozelo/cirurgia , Articulação do Tornozelo/diagnóstico por imagem , Articulação do Tornozelo/cirurgia , Artroscopia , Humanos , Masculino , Pessoa de Meia-Idade , Osteonecrose/diagnóstico por imagem , Osteonecrose/etiologia , Osteonecrose/cirurgia , Tálus/diagnóstico por imagem , Tálus/cirurgia
2.
Acta Orthop Belg ; 88(4): 781-787, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36800664

RESUMO

Background and study aims: Here, we report the presence of radiolucent lines in a consecutive group of 93 partial knee replacements (UKA). Materials and methods: The prospective study was conducted from 2011 to 2019 with a minimum follow-up of two years. Clinical data and radiographs were recorded. Of the 93 UKA, 65 were cemented. The Oxford Knee Score was recorded before and two years after surgery. In 75 cases, the follow-up was conducted at > 2 years. A lateral knee replacement was performed in 12 cases. In one case, a medial UKA with patellofemoral prosthesis was performed. Results: In eight patients (8.6%), a radiolucent line (RLL) underneath the tibia component was observed. In four of these eight patients, RLLs were non-progressive, without clinical implications. In two cemented UKAs, RLLs were progressive and were revised with total knee arthroplasty. Early severe osteopenia of the tibia (zone 1 to 7) in the frontal view was observed in two cementless medial UKA cases. The demineralisation occurred spontaneously five months after surgery. We diagnosed two early deep infections, one of which was treated locally. Conclusions: RLLs were present in 8.6% of the patients. Even in severe cases of osteopenia, spontaneous recovery of RLLs is possible with cementless UKAs.


Assuntos
Artroplastia do Joelho , Prótese do Joelho , Osteoartrite do Joelho , Humanos , Artroplastia do Joelho/efeitos adversos , Estudos Prospectivos , Tíbia/diagnóstico por imagem , Tíbia/cirurgia , Desenho de Prótese , Osteoartrite do Joelho/diagnóstico por imagem , Osteoartrite do Joelho/cirurgia , Resultado do Tratamento , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/cirurgia
3.
Arch Orthop Trauma Surg ; 142(12): 3589-3597, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33993361

RESUMO

PURPOSE: Currently, accepted treatment for periprosthetic femoral fractures with loose femoral stem indicates its revision; however, recent studies have proposed treating Vancouver type B2 fractures via internal fixation without stem revision, particularly in the elderly or multi-morbid patients. Despite indications for stem revision, some surgeons tend to perform internal fixation. The main goal of this study was therefore to identify the parameters that were significantly different comparing internal fixation to stem revision for Vancouver type B2 fractures. METHODS: Eighty-one Vancouver B2 periprosthetic femoral fractures, treated between 2010 and 2019, were analysed. The internal fixation (ORIF) and the revision groups were compared. Patients' age, BMI, American Society of Anaesthesiologists (ASA) score, anaesthesia type, operating time, blood loss, surgeons' experience, post-operative weight-bearing, length of hospital stay, and radiological outcome using AGORA roentgenographic assessment were analysed. RESULTS: Patients chosen for ORIF were significantly older than those treated by stem revision (85.4 vs 75.1 years; p = 0.002). Blood loss was 390.7 and 1141.6 ml in the ORIF and revision groups, respectively (p < 0.0001). The surgical times were 134.5 and 225 min in the ORIF and revision groups, respectively (p < 0.0001). Our analysis of BMI, ASA score, anaesthesia type, length of hospital stay, surgeons' experience and radiological outcome, were not significantly different between the two groups. CONCLUSION: Revision did not exhibit better radiological results; moreover, internal fixation resulted in significantly less perioperative blood loss and a shorter operating time, concluding that ORIF is a viable alternative to revision arthroplasty, particularly in older patients.


Assuntos
Artroplastia de Quadril , Fraturas do Fêmur , Fraturas Periprotéticas , Humanos , Idoso , Fraturas Periprotéticas/cirurgia , Artroplastia de Quadril/métodos , Reoperação/métodos , Fixação Interna de Fraturas/métodos , Fraturas do Fêmur/cirurgia , Estudos Retrospectivos , Resultado do Tratamento
4.
Eur Spine J ; 29(8): 2000-2009, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32240373

RESUMO

PURPOSE: There is insufficient information regarding axial plane characteristics of scoliosis despite its 3D nature. The posterior-anterior vertebral vector (VV) has been proposed to characterize the axial plane appearances of the thoracic scoliosis. This study aimed to highlight the importance of knowledge of axial plane features when determining fusion levels and correction techniques of thoracic curves. METHODS: Altogether, 233 thoracic curves were analyzed using the VV after proving its usability instead of 3D angles to determine axial plane parameters such as apical vertebral (APV) axial rotations, APV lateral displacement, and intervertebral rotations (IVR). K-means clustering and regression analysis were used to identify axial plane curve patterns and determine the relationship between the coronal angles and axial plane characteristics, respectively. RESULTS: A close correlation was found between 3D angles and VV projected angles. Eight axial plane clusters were distinct, exhibiting different lateral APV displacement toward the interacetabular axis with relatively small axial rotations and a simultaneous decrease in sagittal curves. The regression analysis showed that the correlation of coronal curve magnitude was significantly stronger (r = 0.78) with APV lateral translation than with APV axial rotation (r = 0.65). CONCLUSION: Based on these findings, the primary goal of scoliosis correction should focus on minimizing lateral translation rather than eliminating axial rotation. Knowing the IVR in the axial plane helps accurately determine the limits of the structural curves. VV-based axial views can facilitate the accurate determination of the end vertebrae and selection of the appropriate correction technique of the curve. These slides can be retrieved under Electronic Supplementary Material.


Assuntos
Procedimentos Ortopédicos , Escoliose , Fusão Vertebral , Humanos , Análise de Regressão , Estudos Retrospectivos , Escoliose/diagnóstico por imagem , Escoliose/cirurgia , Vértebras Torácicas/diagnóstico por imagem , Vértebras Torácicas/cirurgia , Traduções , Resultado do Tratamento
5.
Orthop Traumatol Surg Res ; 105(2): 351-359, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30665877

RESUMO

Idiopathic scoliosis is a three-dimensional (3D) deformity of the spine. In clinical practice, however, the diagnosis and treatment of scoliosis consider only two dimensions (2D) as they rely solely on postero-anterior (PA) and lateral radiographs. Thus, the projections of the deformity are evaluated in only the coronal and sagittal planes, whereas those in the axial plane are disregarded, precluding an accurate assessment of the 3D deformity. A universal dogma in engineering is that designing a 3D object requires drawing projections of the object in all three planes. Similarly, when dealing with a 3D deformity, knowledge of the abnormalities in all three planes is crucial, as each plane is as important as the other two planes. This article reviews the chronological development of axial plane imaging and spinal deformity measurement.


Assuntos
Imageamento Tridimensional/métodos , Radiografia/métodos , Escoliose/diagnóstico , Vértebras Torácicas/diagnóstico por imagem , Humanos
6.
Eur Spine J ; 27(9): 2120-2129, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-29623419

RESUMO

PURPOSE: The global appearance of scoliosis in the horizontal plane is not really known. Therefore, the aims of this study were to analyze scoliosis in the horizontal plane using vertebral vectors in two patients classified with the same Lenke group, and to highlight the importance of the information obtained from these vertebral vector-based top-view images in clinical practice. METHODS: Two identical cases of scoliosis were selected, based on preoperative full-body standing anteroposterior and lateral radiographs obtained by the EOS™ 2D/3D system. Three-dimensional (3D) surface reconstructions of the spinal curves were performed by using sterEOS™ 3D software before and after surgery. In both patients, we also determined the vertebral vectors and horizontal plane coordinates for analyzing the curves mathematically before and after surgery. RESULTS: Despite the identical appearance of spinal curves in the frontal and sagittal planes, the horizontal views seemed to be significantly different. The vertebral vectors in the horizontal plane provided different types of parameters regarding scoliosis and the impact of surgical treatment: reducing lateral deviations, achieving harmony of the curves in the sagittal plane, and reducing rotations in the horizontal plane. CONCLUSIONS: Vertebral vectors allow the evolution of scoliosis curve projections in the horizontal plane before and after surgical treatment, along with representation of the entire spine. The top view in the horizontal plane is essential to completely evaluate the scoliosis curves, because, despite the similar representations in the frontal and sagittal planes, the occurrence of scoliosis in the horizontal plane can be completely different. These slides can be retrieved under Electronic Supplementary Material.


Assuntos
Escoliose/diagnóstico por imagem , Coluna Vertebral/diagnóstico por imagem , Adolescente , Feminino , Humanos , Imageamento Tridimensional/métodos , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/cirurgia , Masculino , Período Pós-Operatório , Período Pré-Operatório , Radiografia , Estudos Retrospectivos , Escoliose/cirurgia , Software , Coluna Vertebral/cirurgia , Vértebras Torácicas/diagnóstico por imagem , Vértebras Torácicas/cirurgia
7.
Orv Hetil ; 153(8): 289-95, 2012 Feb 26.
Artigo em Húngaro | MEDLINE | ID: mdl-22330840

RESUMO

The EOS™ X-ray machine, based on a Nobel prize-winning invention in Physics in the field of particle detection, is capable of simultaneously capturing biplanar X-ray images by slot scanning of the whole body in an upright, physiological load-bearing position, using ultra low radiation doses. The simultaneous capture of spatially calibrated anterioposterior and lateral images allows the performance of a three-dimensional (3D) surface reconstruction of the skeletal system by a special software. Parts of the skeletal system in X-ray images and 3D-reconstructed models appear in true 1:1 scale for size and volume, thus spinal and vertebral parameters, lower limb axis lengths and angles, as well as any relevant clinical parameters in orthopedic practice could be very precisely measured and calculated. Visualization of 3D reconstructed models in various views by the sterEOS 3D software enables the presentation of top view images, through which one can analyze the rotational conditions of lower limbs, joints and spine deformities in horizontal plane and this provides revolutionary novel possibilities in orthopedic surgery, especially in spine surgery.


Assuntos
Imageamento Tridimensional , Procedimentos Ortopédicos/métodos , Radiografia/instrumentação , Humanos , Processamento de Imagem Assistida por Computador , Doses de Radiação , Radiografia/estatística & dados numéricos , Coluna Vertebral/diagnóstico por imagem
8.
Int Orthop ; 36(7): 1325-31, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22371113

RESUMO

BACKGROUND: The EOS™ X-ray machine, based on a Nobel prize-winning invention in physics in the field of particle detection, is capable of a simultaneous capture of biplanar X-ray images by slot scanning of the whole body in an upright, physiological load-bearing position, using ultra-low radiation doses. The simultaneous capture of spatially calibrated anterioposterior and lateral images provides a three-dimensional (3D) surface reconstruction of the skeletal system using a special software. Parts of the skeletal system in X-ray images and 3D-reconstructed models appear in true 1:1 scale for size and volume, thus spinal and vertebral parameters, lower limb axis lengths and angles, as well as any relevant clinical parameters in orthopaedic practice can be very precisely measured and calculated. Visualisation of 3D reconstructed models in various views by sterEOS 3D software enables presentation of top view images to help analyse rotational conditions of lower limbs, joints and spine deformities in the horizontal plane, providing revolutionary novel possibilities in orthopaedic surgery, especially in spine surgery. APPROACH AND CONCLUSIONS: Our department has been extensively using the very first commercially available EOS™ imaging system worldwide for routine orthopaedic diagnostics since June 2007. During this period of about 4.5 years, more than 5,700 standard examinations have been carried out, about a third of them in spine deformity cases and the rest in lower limb orthopaedic cases. In this mini-review, general principles and uses of this groundbreaking integrated orthopaedic solution is reviewed with a few highlighted examples from our own clinical practice.


Assuntos
Processamento de Imagem Assistida por Computador/métodos , Imageamento Tridimensional/métodos , Procedimentos Ortopédicos/métodos , Prática Profissional , Radiografia/métodos , Adolescente , Idoso , Feminino , Humanos , Processamento de Imagem Assistida por Computador/instrumentação , Imageamento Tridimensional/instrumentação , Pessoa de Meia-Idade , Procedimentos Ortopédicos/instrumentação , Radiografia/instrumentação
9.
Int Orthop ; 36(6): 1291-7, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22095137

RESUMO

PURPOSE: EOS 2D/3D is an integrated, low-dose orthopedic digital radioimaging solution, which, due to its groundbreaking properties, has recently shown an increasing application in scoliosis surgery. Its integrated sterEOS 3D software allows creation of patient-specific three-dimensional (3D) lower limb models, and can produce geometrical parameters in 3D. Currently there are a limited number of reports on EOS for lower limb applications. METHODS: Three-dimensional reconstructions of 256 hip and knee joints of 128 healthy subjects, as well as 53 hips and 46 knees of 69 patients with hip or knee arthritis, were evaluated based on orthogonal EOS two-dimensional (2D) images. Measurements for hips included femur and tibia length, total length of the extremity, femoral antetorsion and offset, femoral neck length, neck-shaft and hip-knee-shaft (HKS) angles. Lower limb alignment in both frontal and sagittal planes were determined in normal and arthritic knees. Values were compared with those obtained by standard methods published by others. RESULTS: Normal hip and knee geometrical parameters were found in our healthy subjects. In osteoarthritic cases, values for neck-shaft angle, femoral antetorsion, femur length and total length of the extremity were shown to decrease non-significantly. Evaluation of lower limb alignment in healthy and arthritic knees showed normal values in healthy subjects apart from three cases with an average six degrees varus. Arthritic knees were most frequently found to have a varus angulation, with the exception of 11 cases with normal or valgus alignment. CONCLUSION: EOS 2D/3D with its sterEOS 3D reconstruction is useful for a comprehensive 3D examination of the lower limb. In the near future it may be suitable for daily routine diagnostics of orthopedic lower limb deformities as a primary examination method.


Assuntos
Articulação do Quadril/patologia , Imageamento Tridimensional/instrumentação , Articulação do Joelho/patologia , Interpretação de Imagem Radiográfica Assistida por Computador , Radiografia/métodos , Idoso , Idoso de 80 Anos ou mais , Mau Alinhamento Ósseo/diagnóstico por imagem , Mau Alinhamento Ósseo/patologia , Feminino , Articulação do Quadril/diagnóstico por imagem , Humanos , Articulação do Joelho/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Valores de Referência , Software
10.
Orv Hetil ; 152(49): 1965-70, 2011 Dec 04.
Artigo em Húngaro | MEDLINE | ID: mdl-22106164

RESUMO

UNLABELLED: Type 1 neurofibromatosis is an autosomal dominant hamartosis caused by mutations of the neurofibromin-1 gene. The classic features of the clinical phenotype include the presence of café-au-lait spots, neurofibromas, axillary and inguinal freckling, Lisch-nodules and deformities of the skeletal system, as well as the risk of developing multiple tumors, especially in the central nervous system. However, it is known from the literature that the phenotypic variability can pose a huge diagnostic difficulty. AIMS: Our institute performs molecular genetic testing of the neurofibromin-1 gene since 2008; during this period several unusual phenotypic variants were found. RESULTS, CONCLUSION: The reported four cases represent interesting phenotypic variants or diagnostic challenges in which the final diagnosis was established by molecular genetic analysis.


Assuntos
Genes da Neurofibromatose 1 , Mutação , Neurofibromatose 1/diagnóstico , Neurofibromatose 1/genética , Adolescente , Adulto , Manchas Café com Leite/genética , Criança , Feminino , Aconselhamento Genético , Humanos , Masculino , Neurofibroma/genética , Neurofibroma Plexiforme/genética , Neurofibromina 1/genética , Linhagem , Fenótipo , Diagnóstico Pré-Natal , Escoliose/genética
11.
Orv Hetil ; 152(11): 415-9, 2011 Mar 13.
Artigo em Húngaro | MEDLINE | ID: mdl-21362601

RESUMO

UNLABELLED: Type 1 neurofibromatosis is an autosomal dominant hamartosis, caused by mutations of the gene neurofibromin-1. The variable clinical phenotype is characterized by café-au-lait spots, benign neurofibromas, axillary, inguinal hyperpigmentations, iris hamartomas, skeletal deformities and risk of neurofibroma-development. Pathogenic variations of neurofibromin-1 arise as de novo mutations in approx. 50% of the cases. AIMS: Molecular genetic testing of neurofibromin-1 gene has been performed in our department since 2008; the following report summarizes our experiences. METHODS: 40 patients, presenting symptoms of type 1 neurofibromatosis, were screened by sequencing or multiplex ligation-dependent probe amplification. RESULTS: Pathogenic alterations were identified in 31 cases, 8 patients presented novel mutations. In 8 affected, no mutations were detected by sequencing; one of these patients had a deletion affecting the entire gene. CONCLUSIONS: Sequencing of the neurofibromin-1 gene and screening for rearrangements are useful in identifying pathogenic alterations in most of the cases.


Assuntos
Genes da Neurofibromatose 1 , Testes Genéticos , Mutação , Neurofibromatose 1/diagnóstico , Neurofibromatose 1/genética , Neurofibromina 1/genética , Adulto , Idoso , Códon sem Sentido , Feminino , Deleção de Genes , Humanos , Masculino , Pessoa de Meia-Idade , Mutagênese Insercional , Mutação de Sentido Incorreto , Linhagem , Análise de Sequência de DNA
12.
Spine (Phila Pa 1976) ; 36(2): E123-30, 2011 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-21228692

RESUMO

STUDY DESIGN: a genetic association study was performed on 126 patients with adolescent idiopathic scoliosis and 197 healthy controls from independent Hungarian pedigrees. OBJECTIVE: to reveal implication of promoter polymorphisms of bone morphogenetic protein 4 (BMP4), interleukin-6 (IL6), leptin, matrix metalloproteinase-3 (MMP3), melatonin 1B receptor (MTNR1B) genes in adolescent idiopathic scoliosis (AIS). Combinatorial association of these candidate genes was also studied to detect additive effect of certain single-nucleotide polymorphism (SNP) patterns. SUMMARY OF BACKGROUND DATA: it was previously unraveled that IL6, MMP3, and MTNR1B genes could be considered as predisposition genes of AIS. Since BMP4 and leptin play a central role in bone formation and remodeling and are in direct interaction with melatonin, IL6, and MMP3, these also can be potential predisposition genes. METHODS: the genotyping was determined by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: at a single gene level, no significant differences were found for allele and genotype frequencies of the polymorphisms of these genes between cases or controls; therefore, the formerly detected association of IL6, MMP3, and MTNR1B with AIS was not confirmed in the Hungarian population by independent SNP analysis. However, significantly increased AIS risk was observed at particular combinations of genotypes of paired SNPs of the candidate genes. CONCLUSIONS: the genetic effect of promoter polymorphisms of BMP4, IL6, leptin, MMP3, and MTNR1B can be synergistic for susceptibility to AIS. The combinatorial effect can modulate the final biological impact of many susceptibility polymorphisms; therefore, this should be considered at the comparison of results from case-control studies of different populations.


Assuntos
Proteína Morfogenética Óssea 4/genética , Interleucina-6/genética , Leptina/genética , Metaloproteinase 3 da Matriz/genética , Polimorfismo de Nucleotídeo Único , Receptor MT2 de Melatonina/genética , Escoliose/genética , Adolescente , Feminino , Frequência do Gene , Redes Reguladoras de Genes , Predisposição Genética para Doença , Genótipo , Humanos , Masculino , Modelos Genéticos , Regiões Promotoras Genéticas/genética , Adulto Jovem
13.
Bull Acad Natl Med ; 195(3): 629-42; discussion 642-3, 2011 Mar.
Artigo em Francês | MEDLINE | ID: mdl-22292310

RESUMO

The EOS system is a new medical imaging device based on low-dose X-rays, gaseous detectors and dedicated software for 3D reconstruction. It was developed by Nobel prizewinner Georges Charpak. A new concept--the vertebral vector--is used to facilitate the interpretation of EOS data, especially in the horizontal plane. We studied 95 cases of idiopathic scoliosis before and after surgery by means of classical methods and using vertebral vectors, in order to compare the accuracy of the two approaches. The vertebral vector permits simultaneous analysis of the scoliotic curvature in the frontal, sagittal and horizontal planes, as precisely as classical methods. The use of the vertebral vector simplifies and facilitates the interpretation of the mass of information provided by EOS. After analyzing the horizontal data, the first goal of corrective intervention would be to reduce the lateral vertebral deviation. The reduction in vertebral rotation seems less important. This is a new element in the therapeutic management of spinal deformations.


Assuntos
Imageamento Tridimensional/métodos , Escoliose/diagnóstico por imagem , Coluna Vertebral/diagnóstico por imagem , Adolescente , Feminino , Humanos , Masculino , Prognóstico , Radiografia , Escoliose/cirurgia , Coluna Vertebral/cirurgia
14.
Int Orthop ; 34(8): 1245-9, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19997731

RESUMO

A cross-sectional epidemiological study via personal interviews was performed regarding low back pain and its related clinical aspects in a Hungarian sample of 10,000 people. Joining the international campaign of the "Bone and Joint Decade", our aim was to give data on low back pain prevalence and to explore the underlying possible clinical conditions in a Central European adult and adolescent population. Ten thousand people aged 14-65, selected randomly by the Hungarian central office of statistics from three counties of the south-western Hungarian region, were surveyed using a special questionnaire focusing on low back pain and other degenerative spinal symptoms. People with low back pain complaints and written consent were asked to participate in a further clinical investigation, where radiological and clinical assessment was performed. A total of 4,389 persons (44.1%) reported low back pain in the last month at the time of the survey. Work absenteeism due to low back pain affected 2,140 persons (21.5%). A total of 292 people (2.9%) had already undergone spinal surgery. Upon request 682 people came for a clinical follow-up, where thorough physical examination and radiological analysis was performed and results were statistically interpreted. The Oswestry disability index (ODI) in the examined group of patients averaged 35.1%; radiological degenerative signs were observed in 392/682 (57.5%). Individuals with signs of radiological degeneration had a statistically significant higher ODI value, age, and a higher, yet not significantly increased BMI value than radiographically negative patients (p < 0.05). Co-existence of hip and knee osteoarthritis was also investigated. Higher osteoarthritis prevalence was found in individuals with radiographic signs of spinal degeneration. Details of the survey and clinical investigations are discussed.


Assuntos
Deslocamento do Disco Intervertebral/epidemiologia , Dor Lombar/epidemiologia , Vértebras Lombares/patologia , Adolescente , Adulto , Idoso , Comorbidade , Estudos Transversais , Avaliação da Deficiência , Feminino , Humanos , Hungria/epidemiologia , Deslocamento do Disco Intervertebral/diagnóstico por imagem , Deslocamento do Disco Intervertebral/fisiopatologia , Dor Lombar/diagnóstico por imagem , Dor Lombar/fisiopatologia , Vértebras Lombares/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Osteoartrite do Quadril/epidemiologia , Osteoartrite do Joelho/epidemiologia , Prevalência , Radiografia , Inquéritos e Questionários , Adulto Jovem
15.
Am J Sports Med ; 37 Suppl 1: 50S-57S, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19934437

RESUMO

BACKGROUND: A focal cartilage lesion has limited capacity to heal, and the repair modalities used at present are still unable to provide a universal solution. Pure cartilage graft implantation appears to be a simple option, but it has not been applied widely as cartilage will not reattach easily to the subchondral bone. HYPOTHESIS: We used a multiple-incision technique (processed chondrograft) to increase cartilage graft surface. We hypothesized that pure cartilage graft with augmented osteochondral fusion capacity may be used for cartilage repair and we compared this method with other repair techniques. STUDY DESIGN: Controlled laboratory study. METHODS: Full-thickness focal cartilage defects were created on the medial femoral condyle of 9-month-old pigs; defects were repaired using various methods including bone marrow stimulation, autologous chondrocyte implantation, and processed chondrograft. After the repair, at weeks 6 and 24, macroscopic and histologic evaluation was carried out. RESULTS: Compared with other methods, processed chondrograft was found to be similarly effective in cartilage repair. Defects without repair and defects treated with bone marrow stimulation appeared slightly irregular with fibrocartilage filling. Autologous chondrocyte implantation produced hyalinelike cartilage, although its cellular organization was distinguishable from the surrounding articular cartilage. Processed chondrograft demonstrated good osteochondral integration, and the resulting tissue appeared to be hyaline cartilage. CONCLUSION: The applied cartilage surface processing method allows acceptable osteochondral integration, and the repair tissue appears to have good macroscopic and histologic characteristics. CLINICAL RELEVANCE: If further studies confirm its efficacy, this technique could be considered for human application in the future.


Assuntos
Cartilagem Articular/cirurgia , Cartilagem/transplante , Traumatismos do Joelho/cirurgia , Procedimentos Ortopédicos/métodos , Animais , Cartilagem Articular/lesões , Avaliação de Resultados em Cuidados de Saúde , Suínos , Transplante Homólogo
16.
Am J Med Genet A ; 140(16): 1726-36, 2006 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-16835913

RESUMO

Frontometaphyseal dysplasia is an X-linked trait primarily characterized by a skeletal dysplasia comprising hyperostosis of the skull and modeling anomalies of the tubular bones. Extraskeletal features include tracheobronchial, cardiac, and urological malformations. A proportion of individuals have missense mutations or small deletions in the X-linked gene, FLNA. We report here our experience with comprehensive screening of the FLNA gene in a group of 23 unrelated probands (11 familial instances, 12 simplex cases; total affected individuals 32) with FMD. We found missense mutations leading to substitutions in the actin-binding domain and within filamin repeats 9, 10, 14, 16, 22, and 23 of filamin A in 13/23 (57%) of individuals in this cohort. Some mutations present with a male phenotype that is characterized by a severe skeletal dysplasia, cardiac, and genitourinary malformations that leads to perinatal death. Although no phenotypic feature consistently discriminates between females with FMD who are heterozygous for FLNA mutations and those in whom no FLNA mutation can be identified, there is a difference in the degree of skewing of X-inactivation between these two groups. This observation suggests that locus heterogeneity may exist for this disorder.


Assuntos
Proteínas Contráteis/genética , Genes Ligados ao Cromossomo X , Variação Genética , Proteínas dos Microfilamentos/genética , Mutação , Osteocondrodisplasias/genética , Adulto , Pré-Escolar , Estudos de Coortes , Feminino , Filaminas , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Osteocondrodisplasias/diagnóstico , Osteocondrodisplasias/diagnóstico por imagem , Osteocondrodisplasias/patologia , Fenótipo , Radiografia , Inativação do Cromossomo X/genética
17.
Eur Spine J ; 14(8): 765-71, 2005 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-16012842

RESUMO

This is a retrospective study of 76 children who had had malignant tumours treated with laminectomy or laminoplasty and/or radiation therapy affecting the spine. Spinal tumours in children are extremely rare. However, their treatment can result in progressive spinal deformity. Radiation therapy affecting the growing spine can lead to asymmetric vertebral growth, causing kyphosis and/or scoliosis. These spinal deformities pose one of the most challenging problems for the spine surgeon. The aim of this article is to describe late-onset post-laminectomy/post-radiation spinal deformities and to evaluate the results of their treatment. Seventy-six children, with a mean age of 4 years and 7 months (range, 2 months to 16 years), underwent surgical removal of malignant tumours, between 1961 and 1995. Sixty-seven of them developed post-laminectomy/post-radiation spinal deformity. Conservative treatment consisted of bracing and corrective plaster casts. In 46 cases the deformity was treated surgically. A distraction plaster cast was used as preoperative preparation in the more severe and rigid curves, with or without neurological impairment. Surgery consisted of combined anterior and posterior fusion in 39 cases and posterior fusion in seven cases. Posterior instrumentation was used in 38 cases. The mean follow-up period was 6 years and 7 months (range, 9 months to 20 years and 2 months). Nine children did not develop deformity following the primary tumour treatment. One of them underwent laminectomy with posterolateral fusion and eight had laminoplasty combined with external immobilisation. Forty-six children developed iatrogenic kyphosis and underwent surgical correction from a mean of 75 degrees pre-correction to a mean of 32 degrees . The mean scoliotic angle correction was 66 degrees preoperatively to 34 degrees postoperatively. At follow-up, the mean correction loss was 7 degrees in the sagittal plane and 5 degrees in the coronal plane. Preoperative distraction plaster cast treatment resulted in a correction of 39% in kyphosis and of 58% in scoliosis, and in a partial or complete recovery of neurological deficits in all but one patient. In severe and rigid curves that develop following treatment of paediatric spinal tumours, preoperative application of a distraction plaster cast can reduce deformity and facilitate surgical correction. Furthermore, in the case of pure bony compression of the spinal cord due to the apical vertebra of the deformity, treatment with the distraction plaster can result in recovery from the neurological impairment. The prevention of post-laminectomy/post-radiation spine deformities is emphasised. Rigid external immobilisation for a period of 4 months in the cervical spine and of 6 months in the thoracic spine is recommended after both laminoplasty and laminectomy with posterolateral fusion.


Assuntos
Doença Iatrogênica , Laminectomia/efeitos adversos , Curvaturas da Coluna Vertebral/etiologia , Neoplasias da Coluna Vertebral , Coluna Vertebral , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Estudos Retrospectivos , Neoplasias da Coluna Vertebral/radioterapia , Neoplasias da Coluna Vertebral/cirurgia , Coluna Vertebral/anormalidades , Coluna Vertebral/patologia , Coluna Vertebral/cirurgia , Resultado do Tratamento
18.
Am J Med Genet A ; 116A(3): 272-7, 2003 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-12503106

RESUMO

Frontometaphyseal dysplasia is a rare genetic syndrome affecting the skeletal system and connective tissue. It is believed to be inherited as an X-linked trait. Features of frontometaphyseal dysplasia overlap with other skeletal dysplasias. Prominent supraorbital ridges, radiologic evidence of cranial hyperostosis, and flared metaphyses are characteristic. Scoliosis, a rare associated finding, is usually mild, and familial progressive scoliosis has not been reported so far. The skeletal dysplasia and the associated clinical findings show significant intra- and interfamilial variability. The syndrome has been suggested to be an allelic variant of the Melnick-Needles osteodysplasty, an X-linked (dominant) entity. We present two families with frontometaphyseal dysplasia, in which both males and females showed the facial and skeletal features of the syndrome in association with progressive scoliosis. Some of the affected members also had hearing loss and urogenital anomalies, supporting the existence of the recently suggested entity "fronto-otopalatodigital-osteodysplasty syndome".


Assuntos
Anormalidades Múltiplas/patologia , Doenças do Desenvolvimento Ósseo/patologia , Osso Frontal/anormalidades , Escoliose/patologia , Anormalidades Múltiplas/diagnóstico por imagem , Anormalidades Múltiplas/genética , Saúde da Família , Feminino , Heterogeneidade Genética , Humanos , Masculino , Linhagem , Radiografia , Escoliose/diagnóstico por imagem , Escoliose/genética
19.
J Neurosurg ; 97(3 Suppl): 310-6, 2002 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-12408384

RESUMO

OBJECT: In 10 to 50% of cases with neurofibromatosis, skeletal disorders are present, mainly as various deformities of the spine. These deformities can be divided into dystrophic and nondystrophic groups depending on the absence or presence of bone dystrophy. The nondystrophic curves are highly similar to those in idiopathic scoliosis, whereas the dystrophic curves are manifested early and, by progressing inexorably, may lead to neurological symptoms. In this article the authors report on a series of 12 patients (11 with dystrophic and one with nondystrophic deformities) who underwent surgical treatment. METHODS: In the case with a nondystrophic curve, posterolateral instrumentation-assisted fusion was performed. A curvature correction of 70% was achieved in the frontal plane, and at the 2-year follow-up examination neither bone dysplasia nor pseudarthrosis was observed. In the cases with dystrophic curves, preoperative traction for 3 weeks was applied; anterior surgical release was then performed, as was two-stage posterior instrumentation-assisted fusion. In the cases of thoracic kyphoscoliosis in which this treatment protocol was performed, the mean scoliosis correction was 66%, whereas the mean decrease in kyphotic angle was 34.5 degrees. In the cases with thoracolumbar and lumbar curves, the mean correction in the frontal plane was 69.8 degrees, whereas the mean preoperative lumbar kyphosis of 42 degrees was corrected to a mean lordotic angle of 23 degrees. Postoperatively, no hook dislocation was detected. A neurological complication was observed in one case. CONCLUSIONS: The surgical treatment of dystrophic curves always included 360 degrees fusion and the use of a tibial corticocancellous graft, which must be placed on the concave side of the curve in the frontal plane, the graft thereby providing biomechanical support.


Assuntos
Cifose/etiologia , Cifose/cirurgia , Neurofibromatose 1/complicações , Escoliose/etiologia , Escoliose/cirurgia , Adolescente , Adulto , Transplante Ósseo , Criança , Feminino , Humanos , Cifose/diagnóstico por imagem , Masculino , Dispositivos de Fixação Ortopédica , Cuidados Pré-Operatórios , Escoliose/diagnóstico por imagem , Fusão Vertebral , Tíbia , Tomografia Computadorizada por Raios X , Tração , Resultado do Tratamento
20.
J Spinal Disord Tech ; 15(2): 127-32, 2002 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11927821

RESUMO

This retrospective study was performed to evaluate the results of the treatment of late posttraumatic spinal disorders. Five patients with thoracolumbar kyphosis, two with paralytic kyphoscoliosis and two with posttraumatic instability with pain but without neurologic symptoms and apparent deformity, were treated surgically. Various surgical procedures were performed depending on the pathologic conditions. Corrections achieved in the sagittal and frontal planes were analyzed on radiographs after a mean follow-up of 4.4 years. In cases of angular kyphosis, the deformity measured 48.8 degrees on average before operation and 9.3 degrees afterward. Preoperative neurologic impairments were improved in all cases. Patients with paralytic scoliosis benefited from an average surgical correction of 68%. The restoration of truncal balance helped the patients to regain a normal sitting posture. Pain was reduced in all patients after surgery, as it was in patients with low back pain caused by posttraumatic instability without deformity. The results of the current study emphasize the importance of adequate management of spinal injuries to prevent late spinal sequelae.


Assuntos
Cifose/etiologia , Cifose/cirurgia , Escoliose/etiologia , Escoliose/cirurgia , Traumatismos da Coluna Vertebral/complicações , Adolescente , Adulto , Feminino , Humanos , Masculino , Radiografia , Estudos Retrospectivos , Fraturas da Coluna Vertebral/diagnóstico por imagem , Fraturas da Coluna Vertebral/cirurgia , Traumatismos da Coluna Vertebral/cirurgia , Resultado do Tratamento
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