Proportional incidence of interval colorectal cancer in a large population-based faecal immunochemical test screening programme.

BACKGROUND: The European guidelines for quality assurance in colorectal cancer (CRC) screening recommend that interval cancer rate be expressed as a proportion of background incidence rate. AIM: To determine the crude and adjusted proportional incidence of interval CRC in an Italian regional two-yearly faecal immunochemical test (FIT) screening programme. METHODS: The programme (year of implementation, 2005) is targeted at over 1,000,000 people aged 50-69 years. The test is a one-sample OC-Sensor (Eiken Chemical Co., Tokyo, Japan). The study covered one-third of the regional area. Excerpts of 434,295 eligible negative FIT records dated 2005-2012 from 193,193 subjects were retrieved from the regional CRC screening data warehouse. By 31 December 2013, the cohort accumulated 198,302 man-years and 235,370 woman-years. Interval CRCs were identified by record-linkage with the local population-based cancer registry. Their number was divided by the expected number, estimated with age-period-cohort models, to obtain the proportional incidence. RESULTS: The proportional incidence of interval CRC for men and women was, respectively, 0.06 (95% confidence interval (CI), 0.04-0.09) and 0.17 (95% CI, 0.13-0.23) in the first interval year, and 0.21 (95% CI, 0.16-0.26) and 0.28 (95% CI, 0.22-0.36) in the second year. CONCLUSIONS: The results were acceptable and in line with previous studies.

Easy screening for everyone.

OBJECTIVES: to increase participation of immigrant women at cervical cancer screening programmes. DESIGN: pre-post study to evaluate the efficacy of recall by phone call in immigrant women. SETTING AND PARTICIPANTS: 6,133 immigrant women in Cesena (Emilia-Romagna Region, Northern Italy) who have never made a Pap test in the last three years. MAIN OUTCOME MEASURES: increment of percentage of immigrant women who participated in cervical cancer screening. RESULTS: the recall by phone call and counselling by linguistic mediators to immigrant women from high-pressure to migrate Country moved their participation percentage to cervical screening programmes from 46% (period 2006-2008) to 56% (period 2011-2013). Linguistic mediators contacted 2,131 of these women and they verified that 1,437 of them have not made a Pap test in the last three years. These women were suggested to do the Pap test and 555 of them (39%) did it; these tests cost about 25 euros each for counselling and telephone recall. Pap tests, colposcopies, and histology results permitted to find out and treat: 2 cervical dysplasia of grade I (mild), 3 of grade II (moderate), and 3 of grade III (severe). These 6 women with moderate or severe dysplasia had an average age of 37 years and have never done a Pap test. The cost to find out these cases of moderate or severe dysplasia was about 2,000 euros each. CONCLUSION: the recall phone call and counselling by linguistic mediators is effective and low cost to increase the participation of foreign women in screening programmes.