1.
cAMP sensitive nanochannels driven by conformational transition of a tripeptide-based smart polymer.
Chem Commun (Camb)
; 56(23): 3425-3428, 2020 Mar 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32100737
RESUMO
Inspired by biological nanochannels, a novel cyclic 3',5'-adenosine monophosphate (cAMP)-regulated artificial nanochannel based on a tripeptide Arg-Thr-Ala (RTA) design is developed. Highly specific binding between the tripeptide and cAMP triggers an obvious conformational transition of a smart polymer chain from a contracted state to a swollen one, which leads to a dynamic modulation of the gating behaviours of the nanochannels.