[Clinical observation of LOP chemotherapy combined with radiotherapy in the treatment of early nasal NK/T cell lymphoma].

Objective:To investigate the efficacy and safety of LOP（asparaginase + vincristine + dexamethasone） chemotherapy combined with radiotherapy in patients with nasal NK/T cell lymphoma. Method:Sixty patients with nasal NK/T cell lymphoma admitted to our hospital from February 2012 to February 2016 were selected as the study subject. They were randomly divided into group A and group B, 30 cases in each group. All patients were treated with combined chemotherapy and IMRT（intensity modulated conformal radiotherapy）. The LOP regimen was used in group A and the CHOP（cyclophosphamide + pirarubicin + vincristine + dexamethasone） regimen was used in group B. The short-term efficacy, long-term efficacy and adverse reactions of the two groups were compared. Result:The clinical manifestations of 60 patients mainly included nasal obstruction（81.67%）, accompanied by fever, headache, nosebleed and runny nose. Forty-one patients（68.33%） had only one site of lesion, and 21 patients（35.00%） had multiple sites of lesions. In terms of total remission rate, it was significantly higher in group A than that in group B（93.33% vs. 66.67%, P<0.05）. In terms of adverse reactions, the incidence of bone marrow suppression, gastrointestinal reaction and low-protein reaction was significantly lower in group A than that in group B（P<0.05）. Three patients died in group A and 11 patients died in group B during the 3-year follow-up. The 3-year survival rate of group A was higher than that of group B（P<0.05）. Conclusion:Compared with CHOP+IMRT regimen, the LOP+IMRT regimen for nasal NK/T-cell lymphoma patients resulted in higher overall remission rate, survival rate and lower adverse reactions, so it is worth in clinical promotion.

Hypoxic gas mixtures delivered by anaesthetic machines equipped with a downstream oxygen flowmeter.

The oxygen concentration of fresh gas mixtures delivered to a Bain circuit by a Boyle's anaesthetic machine equipped with leaking oxygen flowmeters was measured at the common gas outlet during free flow and during controlled ventilation of a model lung. The results demonstrate that, despite satisfactory oxygen and nitrous oxide rotameter settings, such a machine can deliver hypoxic fresh gas mixtures irrespective of whether the leaking flowmeter is mounted downstream or upstream. This selective loss of oxygen increases with the size of the leak and increases with the back pressure on the flowmeter assembly during controlled ventilation. A downstream position of the oxygen flowmeter should not be regarded as foolproof. Continuous monitoring of the oxygen concentration of fresh gas mixtures with an in-line oxygen analyzer is recommended.