The toxic effects of chloroquine and hydroxychloroquine on skeletal muscle: a systematic review and meta-analysis.

The aim of this systematic review was to perform qualitative and quantitative analysis on the toxic effects of chloroquine (CQ) and hydroxychloroquine (HCQ) on skeletal muscles. We designed the study according to PRISMA guidelines. Studies for qualitative and quantitative analyses were selected according to the following inclusion criteria: English language; size of sample (> 5 patients), adult (> age of 18) patients, treated with CQ/HCQ for inflammatory diseases, and presenting and not presenting with toxic effects on skeletal muscles. We collected data published from 1990 to April 2020 using PubMed, Cochrane Library, EMBASE, and SciELO. Risk of bias for observational studies was assessed regarding the ROBIN-I scale. Studies with less than five patients (case reports) were selected for an additional qualitative analysis. We used the software Comprehensive Meta-Analysis at the confidence level of 0.05. We identified 23 studies for qualitative analysis (17 case-reports), and five studies were eligible for quantitative analysis. From case reports, 21 patients presented muscle weakness and confirmatory biopsy for CQ/HCQ induced myopathy. From observational studies, 37 patients out of 1,367 patients from five studies presented muscle weakness related to the use of CQ/HCQ, and 252 patients presented elevated levels of muscle enzymes (aldolase, creatine phosphokinase, and lactate dehydrogenase). Four studies presented data on 34 patients with confirmatory biopsy for drug-induced myopathy. No study presented randomized samples. The chronic use of CQ/HCQ may be a risk for drug-induced myopathy. There is substantiated need for proper randomized trials and controlled prospective studies needed to assess the clinical and subclinical stages of CQ/HCQ -induced muscle myopathy.

The effectiveness of microwave disinfection in treating Candida-associated denture stomatitis: a systematic review and metaanalysis.

OBJECTIVE: To evaluate the effectiveness of microwave disinfection in treating Candida-associated denture stomatitis (CADS). MATERIALS AND METHODS: The PubMed/MEDLINE, Embase, and Scopus databases were searched for reports on randomized clinical trials (RCTs) published in English until May 2020 (PROSPERO CRD42020192062) that evaluated the treatment of CADS by using microwave disinfection. The main outcomes were the improvement of clinical signs and/or the decrease in the residual yeast present on the dentures and palatal mucosa. The mean differences, standard deviations, risk ratio, and 95% confidence interval were calculated by using the random-effects model. Heterogeneity was assessed by using Cochran's Q test and I2 values. The level of significance was set at α = 0.05. RESULTS: Five RCTs with 245 participants were included. The descriptive investigations demonstrated that microwave disinfection was as effective (p > 0.05) as 0.2% chlorhexidine, 0.02% sodium hypochlorite, and topical nystatin (100.000 IU/mL), and was superior to topical miconazole in treating CADS. The metaanalysis did not show a statistical difference between microwave disinfection and nystatin (100.000 IU/mL) treatment in terms of mycological counts, cure, and recurrence rates (p > 0.05). CONCLUSION: Microwave disinfection showed comparable results with those of conventional therapies for treating CADS. In addition, treatment with 650 W for 3 min once a week for 14 days had better cost-effect results, indicating both the prevention and treatment of CADS. CLINICAL RELEVANCE: Our findings provide evidence regarding the treatment of CADS using microwave disinfection, and also indicating the best cost-effective option for this treatment modality.

A 3-D Finite Element Study of the Influence of Crown-Implant Ratio on Stress Distribution

The purpose of this study was to assess the influence of the crown height of external hexagon implants on the displacement and distribution of stress to the implant/bone system, using the three-dimensional finite element method. The InVesalius and Rhinoceros 4.0 softwares were used to generate the bone model by computed tomography. Each model was composed of a bone block with one implant (3.75x10.0 mm) with external hexagon connections and crowns with 10 mm, 12.5 mm and 15 mm in height. A 200 N axial and a 100 N oblique (45°) load were applied. The models were solved by the NeiNastran 9.0 and Femap 10.0 softwares to obtain the results that were visualized by maps of displacement, von Mises stress (crown/implant) and maximum principal stress (bone). The crown height under axial load did not influence the stress displacement and concentration, while the oblique loading increased these factors. The highest stress was observed in the neck of the implant screw on the side opposite to the loading. This stress was also transferred to the crown/platform/bone interface. The results of this study suggest that the increase in crown height enhanced stress concentration at the implant/bone tissue and increased displacement in the bone tissue, mainly under oblique loading.

A proposta deste estudo foi avaliar a influência da altura da coroa de implantes de hexágono externo sobre o deslocamento e distribuição de tensões para o sistema implante/osso utilizando o método de elementos finitos. Os softwares InVesalius e Rhinoceros 4.0 foram usados para gerar o modelo de osso por meio de uma tomografia computadorizada. Cada modelo foi composto de um bloco ósseo com um implante (3.75 x 10.0 mm) com conexão de hexágono externo e coroas de 10 mm, 12.5mm e 15 mm em altura. Uma carga axial de 200 N e oblíqua (45°) de 100 N foram aplicadas. Os modelos foram resolvidos pelo software NeiNastram 9.0 e Femap 10.0 para obtenção dos resultados que foram visualizados por meio de mapas de deslocamento, de von Mises (coroa/implante) e tensão máxima principal (osso). A altura da coroa sob carga axial não influenciou o deslocamento e concentração de tensões, enquanto que a carga oblíqua aumentou a ação destes fatores. A maior concentração de tensões foi observada no pescoço do parafuso do implante no lado oposto à aplicação de carga. Esta tensão foi transferida para a interface coroa/plataforma/interface óssea. Os resultados deste estudo sugerem que o aumento da coroa amplia a concentração de tensões no tecido ósseo/implante, aumentando o deslocamento no tecido ósseo, principalmente sob carga oblíqua.

Implantes tipo plataforma modificada: revisión de literatura / Implants modified platform type: literature review

El propósito de esta revisión fue explorar el concepto de Plataforma modificada en Implantología y su desempeño clínico. La definición de plataforma modificada será considerada junto con una revisión de literatura pertinente, con la finalidad de proveer directrices basadas en evidencias científicas. Fueron utilizadas las siguientes bases de datos: Pubmed, Biblioteca Cochrane e ISI. Los criterios de inclusión fueron: artículos clínicos, de laboratorio y de revisión sobre el tema, en lengua inglesa. Fueron seleccionados 40 artículos, utilizando los descriptores "plataforma switching dental implants", "platform shifting and dental implants", "expanded platform dental implant". De acuerdo con esta revisión, los implantes plataforma modificada presentan una tasa de remodelación ósea ( media < 1mm) más favorable que los implantes convencionales. Este hecho parece ser resultante de un conjunto de factores biológicos y mecánicos. El concepto de plataforma modificada tiene importante relevancia en el área estética

The purpose of this revision was to explore the concept of Platform Switching in implantology and its acting in the clinical practice. The concept of platform switching will be considered together with a revision of pertinent literature, with the purpose of providing guidelines based on scientific evidences. The following databases were used: Pubmed, Library Cochrane and ISI in the last 17 years. The inclusion approaches were: clinical articles, laboratorials and of revision on the topic, in English language. 41 articles were selected, using the describers "platform switching dental implants", "platform shifting and dental implants", "expanded platform dental implant". In accordance with this revision, implant them platform switching they present a rate of more favorable bony remodeling that you implant them conventional. This fact seems to be resulting of a group of biological factors and mechanics. The concept of platform switching has important relevance in the aesthetic area