Clinically acquired new challenging dataset for brain SOL segmentation: AJBDS-2023.

Space-occupying lesions (SOL) brain detected on brain MRI are benign and malignant tumors. Several brain tumor segmentation algorithms have been developed but there is a need for a clinically acquired dataset that is used for real-time images. This research is done to facilitate reporting of MRI done for brain tumor detection by incorporating computer-aided detection. Another objective was to make reporting unbiased by decreasing inter-observer errors and expediting daily reporting sessions to decrease radiologists' workload. This is an experimental study. The proposed dataset contains clinically acquired multiplanar, multi-sequential MRI slices (MPMSI) which are used as input to the segmentation model without any preprocessing. The proposed AJBDS-2023 consists of 10667 images of real patients imaging data with a size of 320*320*3. Acquired images have T1W, TW2, Flair, T1W contrast, ADC, and DWI sequences. Pixel-based ground-truth annotated images of the tumor core and edema of 6334 slices are made manually under the supervision of a radiologist. Quantitative assessment of AJBDS-2023 images is done by a novel U-network on 4333 MRI slices. The diagnostic accuracy of our algorithm U-Net trained on AJBDS-2023 was 77.4 precision, 82.3 DSC, 87.4 specificity, 93.8 sensitivity, and 90.4 confidence interval. An experimental analysis of AJBDS-2023 done by the U-Net segmentation model proves that the proposed AJBDS-2023 dataset has images without preprocessing, which is more challenging and provides a more realistic platform for evaluation and analysis of newly developed algorithms in this domain and helps radiologists in MRI brain reporting more realistically.

Colon histology slide classification with deep-learning framework using individual and fused features.

Cancer occurrence rates are gradually rising in the population, which reasons a heavy diagnostic burden globally. The rate of colorectal (bowel) cancer (CC) is gradually rising, and is currently listed as the third most common cancer globally. Therefore, early screening and treatments with a recommended clinical protocol are necessary to trat cancer. The proposed research aim of this paper to develop a Deep-Learning Framework (DLF) to classify the colon histology slides into normal/cancer classes using deep-learning-based features. The stages of the framework include the following: (ⅰ) Image collection, resizing, and pre-processing; (ⅱ) Deep-Features (DF) extraction with a chosen scheme; (ⅲ) Binary classification with a 5-fold cross-validation; and (ⅳ) Verification of the clinical significance. This work classifies the considered image database using the follwing: (ⅰ) Individual DF, (ⅱ) Fused DF, and (ⅲ) Ensemble DF. The achieved results are separately verified using binary classifiers. The proposed work considered 4000 (2000 normal and 2000 cancer) histology slides for the examination. The result of this research confirms that the fused DF helps to achieve a detection accuracy of 99% with the K-Nearest Neighbor (KNN) classifier. In contrast, the individual and ensemble DF provide classification accuracies of 93.25 and 97.25%, respectively.

Cancer Metastasis Prediction and Genomic Biomarker Identification through Machine Learning and eXplainable Artificial Intelligence in Breast Cancer Research.

AIM: Method: This research presents a model combining machine learning (ML) techniques and eXplainable artificial intelligence (XAI) to predict breast cancer (BC) metastasis and reveal important genomic biomarkers in metastasis patients. METHOD: A total of 98 primary BC samples was analyzed, comprising 34 samples from patients who developed distant metastases within a 5-year follow-up period and 44 samples from patients who remained disease-free for at least 5 years after diagnosis. Genomic data were then subjected to biostatistical analysis, followed by the application of the elastic net feature selection method. This technique identified a restricted number of genomic biomarkers associated with BC metastasis. A light gradient boosting machine (LightGBM), categorical boosting (CatBoost), Extreme Gradient Boosting (XGBoost), Gradient Boosting Trees (GBT), and Ada boosting (AdaBoost) algorithms were utilized for prediction. To assess the models' predictive abilities, the accuracy, F1 score, precision, recall, area under the ROC curve (AUC), and Brier score were calculated as performance evaluation metrics. To promote interpretability and overcome the "black box" problem of ML models, a SHapley Additive exPlanations (SHAP) method was employed. RESULTS: The LightGBM model outperformed other models, yielding remarkable accuracy of 96% and an AUC of 99.3%. In addition to biostatistical evaluation, in XAI-based SHAP results, increased expression levels of TSPYL5, ATP5E, CA9, NUP210, SLC37A1, ARIH1, PSMD7, UBQLN1, PRAME, and UBE2T (p ≤ 0.05) were found to be associated with an increased incidence of BC metastasis. Finally, decreased levels of expression of CACTIN, TGFB3, SCUBE2, ARL4D, OR1F1, ALDH4A1, PHF1, and CROCC (p ≤ 0.05) genes were also determined to increase the risk of metastasis in BC. CONCLUSION: The findings of this study may prevent disease progression and metastases and potentially improve clinical outcomes by recommending customized treatment approaches for BC patients.

Gastrointestinal tract disorders classification using ensemble of InceptionNet and proposed GITNet based deep feature with ant colony optimization.

Computer-aided classification of diseases of the gastrointestinal tract (GIT) has become a crucial area of research. Medical science and artificial intelligence have helped medical experts find GIT diseases through endoscopic procedures. Wired endoscopy is a controlled procedure that helps the medical expert in disease diagnosis. Manual screening of the endoscopic frames is a challenging and time taking task for medical experts that also increases the missed rate of the GIT disease. An early diagnosis of GIT disease can save human beings from fatal diseases. An automatic deep feature learning-based system is proposed for GIT disease classification. The adaptive gamma correction and weighting distribution (AGCWD) preprocessing procedure is the first stage of the proposed work that is used for enhancing the intensity of the frames. The deep features are extracted from the frames by deep learning models including InceptionNetV3 and GITNet. Ant Colony Optimization (ACO) procedure is employed for feature optimization. Optimized features are fused serially. The classification operation is performed by variants of support vector machine (SVM) classifiers, including the Cubic SVM (CSVM), Coarse Gaussian SVM (CGSVM), Quadratic SVM (QSVM), and Linear SVM (LSVM) classifiers. The intended model is assessed on two challenging datasets including KVASIR and NERTHUS that consist of eight and four classes respectively. The intended model outperforms as compared with existing methods by achieving an accuracy of 99.32% over the KVASIR dataset and 99.89% accuracy using the NERTHUS dataset.

A Novel Heteromorphous Convolutional Neural Network for Automated Assessment of Tumors in Colon and Lung Histopathology Images.

The automated assessment of tumors in medical image analysis encounters challenges due to the resemblance of colon and lung tumors to non-mitotic nuclei and their heteromorphic characteristics. An accurate assessment of tumor nuclei presence is crucial for determining tumor aggressiveness and grading. This paper proposes a new method called ColonNet, a heteromorphous convolutional neural network (CNN) with a feature grafting methodology categorically configured for analyzing mitotic nuclei in colon and lung histopathology images. The ColonNet model consists of two stages: first, identifying potential mitotic patches within the histopathological imaging areas, and second, categorizing these patches into squamous cell carcinomas, adenocarcinomas (lung), benign (lung), benign (colon), and adenocarcinomas (colon) based on the model's guidelines. We develop and employ our deep CNNs, each capturing distinct structural, textural, and morphological properties of tumor nuclei, to construct the heteromorphous deep CNN. The execution of the proposed ColonNet model is analyzed by its comparison with state-of-the-art CNNs. The results demonstrate that our model surpasses others on the test set, achieving an impressive F1 score of 0.96, sensitivity and specificity of 0.95, and an area under the accuracy curve of 0.95. These outcomes underscore our hybrid model's superior performance, excellent generalization, and accuracy, highlighting its potential as a valuable tool to support pathologists in diagnostic activities.

Breast Cancer Diagnosis Based on IoT and Deep Transfer Learning Enabled by Fog Computing.

Across all countries, both developing and developed, women face the greatest risk of breast cancer. Patients who have their breast cancer diagnosed and staged early have a better chance of receiving treatment before the disease spreads. The automatic analysis and classification of medical images are made possible by today's technology, allowing for quicker and more accurate data processing. The Internet of Things (IoT) is now crucial for the early and remote diagnosis of chronic diseases. In this study, mammography images from the publicly available online repository The Cancer Imaging Archive (TCIA) were used to train a deep transfer learning (DTL) model for an autonomous breast cancer diagnostic system. The data were pre-processed before being fed into the model. A popular deep learning (DL) technique, i.e., convolutional neural networks (CNNs), was combined with transfer learning (TL) techniques such as ResNet50, InceptionV3, AlexNet, VGG16, and VGG19 to boost prediction accuracy along with a support vector machine (SVM) classifier. Extensive simulations were analyzed by employing a variety of performances and network metrics to demonstrate the viability of the proposed paradigm. Outperforming some current works based on mammogram images, the experimental accuracy, precision, sensitivity, specificity, and f1-scores reached 97.99%, 99.51%, 98.43%, 80.08%, and 98.97%, respectively, on the huge dataset of mammography images categorized as benign and malignant, respectively. Incorporating Fog computing technologies, this model safeguards the privacy and security of patient data, reduces the load on centralized servers, and increases the output.

A Comparative Analysis of Optimization Algorithms for Gastrointestinal Abnormalities Recognition and Classification Based on Ensemble XcepNet23 and ResNet18 Features.

Esophagitis, cancerous growths, bleeding, and ulcers are typical symptoms of gastrointestinal disorders, which account for a significant portion of human mortality. For both patients and doctors, traditional diagnostic methods can be exhausting. The major aim of this research is to propose a hybrid method that can accurately diagnose the gastrointestinal tract abnormalities and promote early treatment that will be helpful in reducing the death cases. The major phases of the proposed method are: Dataset Augmentation, Preprocessing, Features Engineering (Features Extraction, Fusion, Optimization), and Classification. Image enhancement is performed using hybrid contrast stretching algorithms. Deep Learning features are extracted through transfer learning from the ResNet18 model and the proposed XcepNet23 model. The obtained deep features are ensembled with the texture features. The ensemble feature vector is optimized using the Binary Dragonfly algorithm (BDA), Moth-Flame Optimization (MFO) algorithm, and Particle Swarm Optimization (PSO) algorithm. In this research, two datasets (Hybrid dataset and Kvasir-V1 dataset) consisting of five and eight classes, respectively, are utilized. Compared to the most recent methods, the accuracy achieved by the proposed method on both datasets was superior. The Q_SVM's accuracies on the Hybrid dataset, which was 100%, and the Kvasir-V1 dataset, which was 99.24%, were both promising.

An Explainable Classification Method Based on Complex Scaling in Histopathology Images for Lung and Colon Cancer.

Lung and colon cancers are among the leading causes of human mortality and morbidity. Early diagnostic work up of these diseases include radiography, ultrasound, magnetic resonance imaging, and computed tomography. Certain blood tumor markers for carcinoma lung and colon also aid in the diagnosis. Despite the lab and diagnostic imaging, histopathology remains the gold standard, which provides cell-level images of tissue under examination. To read these images, a histopathologist spends a large amount of time. Furthermore, using conventional diagnostic methods involve high-end equipment as well. This leads to limited number of patients getting final diagnosis and early treatment. In addition, there are chances of inter-observer errors. In recent years, deep learning has shown promising results in the medical field. This has helped in early diagnosis and treatment according to severity of disease. With the help of EffcientNetV2 models that have been cross-validated and tested fivefold, we propose an automated method for detecting lung (lung adenocarcinoma, lung benign, and lung squamous cell carcinoma) and colon (colon adenocarcinoma and colon benign) cancer subtypes from LC25000 histopathology images. A state-of-the-art deep learning architecture based on the principles of compound scaling and progressive learning, EffcientNetV2 large, medium, and small models. An accuracy of 99.97%, AUC of 99.99%, F1-score of 99.97%, balanced accuracy of 99.97%, and Matthew's correlation coefficient of 99.96% were obtained on the test set using the EffcientNetV2-L model for the 5-class classification of lung and colon cancers, outperforming the existing methods. Using gradCAM, we created visual saliency maps to precisely locate the vital regions in the histopathology images from the test set where the models put more attention during cancer subtype predictions. This visual saliency maps may potentially assist pathologists to design better treatment strategies. Therefore, it is possible to use the proposed pipeline in clinical settings for fully automated lung and colon cancer detection from histopathology images with explainability.

Combined impacts of low oscillating magnetic field and Shliomis theory on mono and hybrid nanofluid flows with nonlinear thermal radiation.

Hybrid nanofluids have become a popular choice for various engineering and industrial applications due to their advanced properties. This study focuses on investigating the consequences of a low oscillating magnetic field on the flow of unsteady mono and hybrid nanofluids over a vertically moving permeable disk. Initially, iron oxide nanoparticles are mixed with water to create a mono nanofluid, which is later transformed into a hybrid nanofluid by adding cobalt nanoparticles. The shape of nanoparticles used is brick-shaped, and an external magnetic field is applied to regulate the flow and heat transfer mechanism using ferromagnetic nanoparticles. Additionally, the nonlinear thermal radiative heat flux is considered for the heat transfer phenomenon. The momentum and rotational motion of the magnetic fluid caused by the rotating disk are formulated using the Shliomis fundamental concept. The numerical analysis of the ordinary differential equations (ODEs) is carried out using the bvp4c technique, and the results are presented in tabular form for the surface drag coefficient and heat transmission at the walls. Moreover, the temperature and velocity distributions are illustrated using graphical representations against relevant parameters. The findings highlight that for a constant negative value for the magnetization parameterϒ<0,the heat transfer rate for hybrid nanofluid is witnessed stronger at a volume fractionϕhnf=0.120,whereas a minimal heat transfer rate is observed for positive values of magnetization parameterϒ>0at the same value of volume fraction.

Skin Lesion Analysis and Cancer Detection Based on Machine/Deep Learning Techniques: A Comprehensive Survey.

The skin is the human body's largest organ and its cancer is considered among the most dangerous kinds of cancer. Various pathological variations in the human body can cause abnormal cell growth due to genetic disorders. These changes in human skin cells are very dangerous. Skin cancer slowly develops over further parts of the body and because of the high mortality rate of skin cancer, early diagnosis is essential. The visual checkup and the manual examination of the skin lesions are very tricky for the determination of skin cancer. Considering these concerns, numerous early recognition approaches have been proposed for skin cancer. With the fast progression in computer-aided diagnosis systems, a variety of deep learning, machine learning, and computer vision approaches were merged for the determination of medical samples and uncommon skin lesion samples. This research provides an extensive literature review of the methodologies, techniques, and approaches applied for the examination of skin lesions to date. This survey includes preprocessing, segmentation, feature extraction, selection, and classification approaches for skin cancer recognition. The results of these approaches are very impressive but still, some challenges occur in the analysis of skin lesions because of complex and rare features. Hence, the main objective is to examine the existing techniques utilized in the discovery of skin cancer by finding the obstacle that helps researchers contribute to future research.

Design of a Honey Badger Optimization Algorithm with a Deep Transfer Learning-Based Osteosarcoma Classification Model.

Osteosarcoma is one of the aggressive bone tumors with numerous histologic patterns. Histopathological inspection is a crucial criterion in the medical diagnosis of Osteosarcoma. Due to the advancement of computing power and hardware technology, pathological image analysis system based on artificial intelligence (AI) were more commonly used. But classifying many intricate pathology images by hand will be challenging for pathologists. The lack of labeling data makes the system difficult to build and costly. This article designs a Honey Badger Optimization with Deep Learning based Automated Osteosarcoma Classification (HBODL-AOC) model. The HBODL-AOC technique's goal is to identify osteosarcoma's existence using medical images. In the presented HBODL-AOC technique, image preprocessing is initially performed by contrast enhancement technique. For feature extraction, the HBODL-AOC technique employs a deep convolutional neural network-based Mobile networks (MobileNet) model with an Adam optimizer for hyperparameter tuning. Finally, the adaptive neuro-fuzzy inference system (ANFIS) approach is implemented for the HBO (Honey Badger Optimization) algorithm can tune osteosarcoma classification and the membership function (MF). To demonstrate the enhanced classification performance of the HBODL-AOC approach, a sequence of simulations was performed. The extensive simulation analysis portrayed the improved performance of the HBODL-AOC technique over existing DL models.

Classification of Brain Tumor from Magnetic Resonance Imaging Using Vision Transformers Ensembling.

The automated classification of brain tumors plays an important role in supporting radiologists in decision making. Recently, vision transformer (ViT)-based deep neural network architectures have gained attention in the computer vision research domain owing to the tremendous success of transformer models in natural language processing. Hence, in this study, the ability of an ensemble of standard ViT models for the diagnosis of brain tumors from T1-weighted (T1w) magnetic resonance imaging (MRI) is investigated. Pretrained and finetuned ViT models (B/16, B/32, L/16, and L/32) on ImageNet were adopted for the classification task. A brain tumor dataset from figshare, consisting of 3064 T1w contrast-enhanced (CE) MRI slices with meningiomas, gliomas, and pituitary tumors, was used for the cross-validation and testing of the ensemble ViT model's ability to perform a three-class classification task. The best individual model was L/32, with an overall test accuracy of 98.2% at 384 × 384 resolution. The ensemble of all four ViT models demonstrated an overall testing accuracy of 98.7% at the same resolution, outperforming individual model's ability at both resolutions and their ensembling at 224 × 224 resolution. In conclusion, an ensemble of ViT models could be deployed for the computer-aided diagnosis of brain tumors based on T1w CE MRI, leading to radiologist relief.

Leukemia segmentation and classification: A comprehensive survey.

Blood is made up of leukocytes (WBCs), erythrocytes (RBCs), and thrombocytes. The ratio of blood cancer diseases is increasing rapidly, among which leukemia is one of the famous cancer which may lead to death. Leukemia cancer is initiated by the unnecessary growth of immature WBCs present in the sponge tissues of bone marrow. It is generally analyzed by etiologists by perceiving slides of blood smear images under a microscope. The morphological features and blood cells count facilitated the etiologists to detect leukemia. Due to the late detection and expensive instruments used for leukemia analysis, the death rate has risen significantly. The fluorescence-based cell sorting technique and manual recounts using a hemocytometer are error-prone and imprecise. Leukemia detection methods consist of pre-processing, segmentation, features extraction, and classification. In this article, recent deep learning methodologies and challenges for leukemia detection are discussed. These methods are helpful to examine the microscopic blood smears images and for the detection of leukemia more accurately.

Gastrointestinal Tract Polyp Anomaly Segmentation on Colonoscopy Images Using Graft-U-Net.

Computer-aided polyp segmentation is a crucial task that supports gastroenterologists in examining and resecting anomalous tissue in the gastrointestinal tract. The disease polyps grow mainly in the colorectal area of the gastrointestinal tract and in the mucous membrane, which has protrusions of micro-abnormal tissue that increase the risk of incurable diseases such as cancer. So, the early examination of polyps can decrease the chance of the polyps growing into cancer, such as adenomas, which can change into cancer. Deep learning-based diagnostic systems play a vital role in diagnosing diseases in the early stages. A deep learning method, Graft-U-Net, is proposed to segment polyps using colonoscopy frames. Graft-U-Net is a modified version of UNet, which comprises three stages, including the preprocessing, encoder, and decoder stages. The preprocessing technique is used to improve the contrast of the colonoscopy frames. Graft-U-Net comprises encoder and decoder blocks where the encoder analyzes features, while the decoder performs the features' synthesizing processes. The Graft-U-Net model offers better segmentation results than existing deep learning models. The experiments were conducted using two open-access datasets, Kvasir-SEG and CVC-ClinicDB. The datasets were prepared from the large bowel of the gastrointestinal tract by performing a colonoscopy procedure. The anticipated model outperforms in terms of its mean Dice of 96.61% and mean Intersection over Union (mIoU) of 82.45% with the Kvasir-SEG dataset. Similarly, with the CVC-ClinicDB dataset, the method achieved a mean Dice of 89.95% and an mIoU of 81.38%.

Multi-Class Classification of Breast Cancer Using 6B-Net with Deep Feature Fusion and Selection Method.

Breast cancer has now overtaken lung cancer as the world's most commonly diagnosed cancer, with thousands of new cases per year. Early detection and classification of breast cancer are necessary to overcome the death rate. Recently, many deep learning-based studies have been proposed for automatic diagnosis and classification of this deadly disease, using histopathology images. This study proposed a novel solution for multi-class breast cancer classification from histopathology images using deep learning. For this purpose, a novel 6B-Net deep CNN model, with feature fusion and selection mechanism, was developed for multi-class breast cancer classification. For the evaluation of the proposed method, two large, publicly available datasets, namely, BreaKHis, with eight classes containing 7909 images, and a breast cancer histopathology dataset, containing 3771 images of four classes, were used. The proposed method achieves a multi-class average accuracy of 94.20%, with a classification training time of 226 s in four classes of breast cancer, and a multi-class average accuracy of 90.10%, with a classification training time of 147 s in eight classes of breast cancer. The experimental outcomes show that the proposed method achieves the highest multi-class average accuracy for breast cancer classification, and hence, the proposed method can effectively be applied for early detection and classification of breast cancer to assist the pathologists in early and accurate diagnosis of breast cancer.

A New Model for Brain Tumor Detection Using Ensemble Transfer Learning and Quantum Variational Classifier.

A brain tumor is an abnormal enlargement of cells if not properly diagnosed. Early detection of a brain tumor is critical for clinical practice and survival rates. Brain tumors arise in a variety of shapes, sizes, and features, with variable treatment options. Manual detection of tumors is difficult, time-consuming, and error-prone. Therefore, a significant requirement for computerized diagnostics systems for accurate brain tumor detection is present. In this research, deep features are extracted from the inceptionv3 model, in which score vector is acquired from softmax and supplied to the quantum variational classifier (QVR) for discrimination between glioma, meningioma, no tumor, and pituitary tumor. The classified tumor images have been passed to the proposed Seg-network where the actual infected region is segmented to analyze the tumor severity level. The outcomes of the reported research have been evaluated on three benchmark datasets such as Kaggle, 2020-BRATS, and local collected images. The model achieved greater than 90% detection scores to prove the proposed model's effectiveness.

Liver Tumor Localization Based on YOLOv3 and 3D-Semantic Segmentation Using Deep Neural Networks.

Worldwide, more than 1.5 million deaths are occur due to liver cancer every year. The use of computed tomography (CT) for early detection of liver cancer could save millions of lives per year. There is also an urgent need for a computerized method to interpret, detect and analyze CT scans reliably, easily, and correctly. However, precise segmentation of minute tumors is a difficult task because of variation in the shape, intensity, size, low contrast of the tumor, and the adjacent tissues of the liver. To address these concerns, a model comprised of three parts: synthetic image generation, localization, and segmentation, is proposed. An optimized generative adversarial network (GAN) is utilized for generation of synthetic images. The generated images are localized by using the improved localization model, in which deep features are extracted from pre-trained Resnet-50 models and fed into a YOLOv3 detector as an input. The proposed modified model localizes and classifies the minute liver tumor with 0.99 mean average precision (mAp). The third part is segmentation, in which pre-trained Inceptionresnetv2 employed as a base-Network of Deeplabv3 and subsequently is trained on fine-tuned parameters with annotated ground masks. The experiments reflect that the proposed approach has achieved greater than 95% accuracy in the testing phase and it is proven that, in comparison to the recently published work in this domain, this research has localized and segmented the liver and minute liver tumor with more accuracy.

Design of Metaheuristic Optimization-Based Vascular Segmentation Techniques for Photoacoustic Images.

Biomedical imaging technologies are designed to offer functional, anatomical, and molecular details related to the internal organs. Photoacoustic imaging (PAI) is becoming familiar among researchers and industrialists. The PAI is found useful in several applications of brain and cancer imaging such as prostate cancer, breast cancer, and ovarian cancer. At the same time, the vessel images hold important medical details which offer strategies for a qualified diagnosis. Recently developed image processing techniques can be employed to segment vessels. Since vessel segmentation on PAI is a difficult process, this paper employs metaheuristic optimization-based vascular segmentation techniques for PAI. The proposed model involves two distinct kinds of vessel segmentation approaches such as Shannon's entropy function (SEF) and multilevel Otsu thresholding (MLOT). Moreover, the threshold value and entropy function in the segmentation process are optimized using three metaheuristics such as the cuckoo search (CS), equilibrium optimizer (EO), and harmony search (HS) algorithms. A detailed experimental analysis is made on benchmark PAI dataset, and the results are inspected under varying aspects. The obtained results pointed out the supremacy of the presented model with a higher accuracy of 98.71%.

A Computer-Aided Diagnosis System Using Deep Learning for Multiclass Skin Lesion Classification.

In the USA, each year, almost 5.4 million people are diagnosed with skin cancer. Melanoma is one of the most dangerous types of skin cancer, and its survival rate is 5%. The development of skin cancer has risen over the last couple of years. Early identification of skin cancer can help reduce the human mortality rate. Dermoscopy is a technology used for the acquisition of skin images. However, the manual inspection process consumes more time and required much cost. The recent development in the area of deep learning showed significant performance for classification tasks. In this research work, a new automated framework is proposed for multiclass skin lesion classification. The proposed framework consists of a series of steps. In the first step, augmentation is performed. For the augmentation process, three operations are performed: rotate 90, right-left flip, and up and down flip. In the second step, deep models are fine-tuned. Two models are opted, such as ResNet-50 and ResNet-101, and updated their layers. In the third step, transfer learning is applied to train both fine-tuned deep models on augmented datasets. In the succeeding stage, features are extracted and performed fusion using a modified serial-based approach. Finally, the fused vector is further enhanced by selecting the best features using the skewness-controlled SVR approach. The final selected features are classified using several machine learning algorithms and selected based on the accuracy value. In the experimental process, the augmented HAM10000 dataset is used and achieved an accuracy of 91.7%. Moreover, the performance of the augmented dataset is better as compared to the original imbalanced dataset. In addition, the proposed method is compared with some recent studies and shows improved performance.